Harold W. MooreProfessor Emeritus, Chemistry |
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Research Interests |
Organic Chemistry | |
| URL | www.chem.uci.edu/people/faculty/halmoore/ | |
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Academic Distinctions |
School of Physical Sciences Distinguished Teaching Award UCI Alumni Association Distinguished Teaching Award Appointments: 1963-65, Postdoctoral Research Associate, Stanford Research Institute Chair of UCI Department of Chemistry Dean of UCI School of Physical Sciences Joined UCI faculty in 1965 |
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| Appointments |
1963-65, Postdoctoral Research Associate, Stanford Research Institute Chair of UCI Department of Chemistry Dean of UCI School of Physical Sciences Joined UCI faculty in 1965 |
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Research Abstract |
The main objective of our research is the discovery of new reactions of synthetic and mechanistic interest. This exploratory program is complemented by target-specific syntheses. In this regard, selected natural products that are structurally amenable to function as bioreductive alkylating agents, and thus potential anticancer agents, are of particular interest. In addition, we are interested in the design and synthesis of non-natural products that will selectively cleave DNA but only subsequent to an activating chemical step. Problems of current interest are the following: (1) synthesis and chemistry of un usual ketenes, e.g. 1; (2) generation and chemistry of unique diradicals such as 2 and bis-quinonemethides 3 as well as o-quinonemethides; (3) synthesis of DNA-cleaving agents such as the silylquinones 4 and 4-alkynyl-4-hydroxycyclobutenones 5; (4) synthesis of naturally occurring quin-ones having structural features as potential bioreductive alkylating agents, e.g., griseusin A; and (5)exploration of a new tandem oxy-Cope/transannular ring closure to polyquinanes 7 and the use of this reaction to synthesize natural products in this series. |
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| Publications | "Synthesis of Angularly-Fused Benzocyclobutenedione Monoketals--Useful Synthetic Intermediates to Angucyclines," Tiedemann, R.; Heileman, M. J.; Schaumann, E.; Moore, H. W. Journal of Organic Chemistry 1999, 64, 2170. | |
| "New Metathesis Methodology Leading to Angularly-Fused Polycyclic Quinones and Related Compounds," Heileman, M. J.; Teidemann, R.; Moore, H. W. Journal of the American Chemical Society 1998, 120, 3801. | ||
| "Cyclobutenone-Based Syntheses of Polyquinanes and Bicyclo[6.3.0]undecanes by Tandem Anionic Oxy-Cope Reactions. Total Synthesis of (+)-Precapnelladiene," MacDougall, J. M.; Verma, S. K.; Santora, V. J.; Turnbull, P.; Hernandez, C.; Moore, H. W. Journal of Organic Chemistry 1998, 63, 6905. | ||
| "Ring Expansions of Cyclobutenones. Unusual Reactions of 2-(2-Ethenylphenyl)-4,4-dimethoxycyclobutenones," Heileman, M. J.; Moore,H. W. Tetrahedron Letters 1998, 39, 3643. | ||
| "Dimethyl Squarate and its Conversion to 3-Ethenyl-4-methoxycyclobutene-1,2-dione and 2-Butyl-6-ethenyl-5-methoxy-1,4-benzoquinone," Liu, H.; Tomooka, C. S..; Simon lL. Xu, Benjamin R. Yerxa, Robert W. Sullivan, Yifeng Xiong and Harold W. Moore, Organic Synthesis 1999, 76, 189. | ||
| "Rearrangements of Cyclobutenones. Synthesis of N-Methyl-7,8-dihydrobenzophenanthridine-9,12-didols and Related Compounds," Hergueta, A. R.; Moore, H. W. Journal of Organic Chemistry 1999, 64, 5979. | ||
| "Synthesis and Thermal Rearrangements of 4-Allyl-4-arylcyclobutenones," Tiedemann, R.; Turnbull, P; Moore, H. W. Journal of Organic Chemistry 1999, 64, 4030. | ||
| "A New Tandem Synthetic Routes to Angular Triquinanes. Synthesis of the Waihoensene Ring System," Ergden, J.; Moore, H. W. Organic Letters 1999, 1, 375. | ||
| "Rearrangements of Linear Triquinanes to the Angular Isomers," MacDougall, J. M.; Moore, H. W. Journal of Organic Chemistry 1999, 64, 7445. | ||
| "Oxy-Cope Rearrangements of Bicyclohepteneones. Synthesis of Bicyclo[5.2.1]decenones and Bicyclo[4.2.1]nonenones," Verma, S. K.; Nguyen, Q. H.; James M. McDougall, J. M.; Fleischer, E. B.: Moore, H. W. Journal of Organic Chemistry 2000, 65, 3379. | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2047 | |
| Last updated | 03/15/2002 | |
