Larry E. OvermanProfessor, Chemistry Distinguished Professor of Chemistry |
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Research Interests |
Organic Chemistry | |
| URL | overiris1.ps.uci.edu/ | |
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Academic Distinctions | International Society of Heterocyclic Chemistry Senior Award, 2005, American Chemical Society Arthur C. Cope Award, 2003, U.C. Irvine Distinguished Faculty Lectureship Award for Research, 2002-2003, Yamada Prize, 2002, 2000 Japan Society for the Promotion of Science Fellowship, 1999 S. T. Li Prize for Achievements in Science and Technology, Earlham College Distinguished Faculty Award 1999, Centenary Medal, Chemical Society, U.K., 1997, American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995, Guggenheim Fellowship, 1993-1994, C.S. Hamilton Award, University of Nebraska, 1993, Javits Neuroscience Investigator Award, 1985-1992; 1992-1999, American Chemical Society Arthur C. Cope Scholar Award, 1989, Visiting Miller Research Fellow, U.C. Berkeley, 1989, Alexander von Humboldt U.S. Senior Scientist Award, 1985-1987, Camille and Henry Dreyfus Teacher-Scholar Award, 1976-1981, U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981, U.C. Irvine Alumni Association Distinguished Research Award, 1979, Alfred P. Sloan Foundation Fellow, 1975-1977 | |
| Appointments | NIH Postdoctoral Fellow, Columbia University, 1969-1971 | |
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Research Abstract |
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Transition metal catalyzed reactions play a prominent role in our methodological studies. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. | |
| Publications |
"Catalytic Asymmetric Intramolecular Aminopalladation: Improved Palladium(II) Catalysts" Journal of Organic Chemistry 2005, 70, 2859-2861 S. F. Kirsch and L. E. Overman |
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"Catalytic Asymmetric Synthesis of Chiral Allylic Esters" Journal of the American Chemical Society 2005, 127, 2866-2867 S. F. Kirsch and L. E. Overman |
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"Toward an Enantioselective Total Synthesis of Sarain A: Construction of an Advanced Intermediate and Rearrangement of the Sarain A Core Under Mild Conditions" Organic Letters 2005, 7, 933-936 C. J. Douglas, S. Hiebert and L. E. Overman |
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"Stereocontrolled Synthesis of Angularly-Substituted 1-Azabicyclic Rings by Cationic 2-Aza-Cope Rearrangements" Organic Letters 2005, 7, 913-916 Z. D. Aron and L. E. Overman |
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"Total Synthesis and Properties of the Crambescidin Core Zwitterionic Acid and Crambescidin 359" Journal of the American Chemical Society 2005, 127, 3380-3390 Z. D. Aron and L. E. Overman |
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"Synthesis of tert-Butyl-Derived Cobalt Oxazoline Palladacycles. Reversal of Palladation Diastereoselectivity and Application to the Asymmetric Rearrangement of N-Aryl Trifluoroacetimidates" Organometallics 2004, 24, 77-81 R. S. Prasad, C. E. Anderson, C. J. Richards and L. E. Overman |
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"Catalytic Asymmetric Synthesis of Chiral Allylic Amines. Evaluation of Ferrocenyloxazoline Palladacyclic Catalysts and Imidate Motifs" Journal of Organic Chemistry 2004, 70, 648-657 C. E. Anderson, Y. Donde, C. J. Douglas and L. E. Overman |
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"Enantioselective Synthesis of Six-Membered Palladacycles Having Metal-Bound Stereogenic Carbons: Isolation and Reactivity of Palladacycles Containing Readily Accessible beta-Hydrogen" Journal of the American Chemical Society 2004, 126, 16820-16833 B. J. Burke and L. E. Overman |
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"Stereocontrolled Construction of Either Stereoisomer of 12-Oxatricyclo[6.3.1.02,7]dodecanes Using Prins-Pinacol Reactions" Organic Letters 2004, 6, 3853-3856 L. E. Overman and E. J. Velthuisen |
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Patents: 1. "Synthesis of Indolizidines Related to the Cardiotonic Pumiliotoxin A Alkaloids" U.S. Patent 4,675,325 (issued June 23, 1987) L. E. Overman and F. Ito 2. "GABA Receptor Antagonists Selective for GABArho Receptors" U. S. Patent 5627169 (issued May 6, 1997) R. Miledi, L. E. Overman, Y. Murata and R. Woodward 3. "Preparation of Crambescidin Core Acid Intermediates and Their Use for Preparing Crambescidin Alkaloid Analogs as Antiviral, Antifungal and/or Antitumor Agents" U.S. Pat. Appl. Publ. (2003) US 2003176697 29 pp., Cont.-in-part of U.S. Ser. No. 18630. L. E. Overman, F. Stappenbeck, A. I. McDonald and Z. D. Aron 4. "A Method for Improved Chemical Synthesis of Guanadinium Alkaloids" Provisional U. S. Patent Application filed June 30, 1999 L. E. Overman and F. Stappenbeck 5. "Preparation of Hexahydropyrrolo[1,2-c]pyrimidines, Guanidinium Alkaloids, as Antiviral, Antifungal and/or Antitumor Agents" PCT Intl. Appl. (2001) WO 2001000626, 222 pp. L. E. Overman, F. Stappenbeck and A. I. McDonald |
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Professional Societies |
American Chemical Society American Association for the Advancement of Sciences National Academy of Sciences American Academy of Arts & Sciences |
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| Other Experience |
Editor-In-Chief, Organic Reactions, 1999—- |
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Board of Consulting Editors, Tetrahedron Publications, 1995—- |
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Editorial Advisory Board, Organic Letters, 1999—- |
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Advisory Board, Advanced Synthesis & Catalysis, 2000—- |
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Honorary Editorial Board, Synlett, 1989—- |
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Board of Directors, Organic Reactions, 1993—- |
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Board of Directors, Organic Syntheses, 1996—- |
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Scientific Advisory Board, Cytokinetics, Inc., 2002—- |
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Consultant, Amgen, 2003—- |
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Consultant, Allergan Pharmaceuticals, 1983—- |
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Consultant, Roche Biosciences, 1987—- |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2042 | |
| Last updated | 04/08/2005 | |
