Rychnovsky Research Group

"Generation, Stability, and Utility of Lithium 4,4′-Di-tert-butylbiphenylide (LiDBB)"

Hill, R. R.; Rychnovsky, S. D. J. Org. Chem. 2016, 81 (22), 10707–10714.

 

 

"Route to Highly Substituted Pyridines"

Hilf, J. A.; Holzwarth, M. S.; Rychnovsky, S. D. J. Org. Chem. J. Org. Chem. 2016, 81, 10376–10382.

 

 

"Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein–Protein Interactions"

Gutierrez, C. B.; Yu, C.; Novitsky E. J.; Huszagh, A. S.; Rychnovsky, S. D.; Huang, L. Anal. Chem., 2016, 88, 8315–8322.

 

 

"Nanomole-Scale Assignment and One-Use Kits for Determining the Absolute Configuration of Secondary Alcohols"

Wagner, A. J.; Miller, S. M.; King, R. P.; Rychnovsky, S. D. J. Org. Chem., 2016, 81, 6253–6265.

 

 

 

 

"Stereoselection in Intramolecular Diels–Alder Reactions of 2-Cyano-1-azadienes: Indolizidine and Quinolizidine Synthesis"

Tay, G. C.; Sizemore, N.; Rychnovsky, S. D. Org. Lett. 2016, 18, 3050.

 

 

                                            

 

 

"Generation, structure and reactivity of tertiary organolithium reagents"

Perry, M. A.; Rychnovsky, S. D. Nat. Prod. Rep. 2015, 32, 517–533.

 

 

"Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis"

Kandur, W. V.; Kao, A.; Vellucci, D.; Huang, L.; Rychnovsky, S. D. Org. Biomol. Chem. 2015, 1, 9793–9807.

 

 

"Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8"

Yu, C.; Mao, H.; Novitsky, E. J.; Tang, X.; Rychnovsky, S. D.; Zheng, N.; Huang, L. Nat. Commun. 2015, 6, 10053.

 

 

"Stereochemical Outcomes in Reductive Cyclizations To Form Spirocyclic Heterocycles"

Perry, M. A.; Hill, R. R.; Leong, J. J.; Rychnovsky, S. D. Org. Lett. 2015, 17, 3268–3271.

 

 

"Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein–protein interactions by mass spectrometry"

Burke, A. M.; Kandur, W.; Novitsky, E. J.; Kaake, R. M.; Yu, C.; Kao, A.; Vellucci, D.; Huang, L.; Rychnovsky, S. D. Org. Biomol. Chem. 2015, 13, 5030–5037.

 

 

“Concise sythesis of (+)-fastigiatine”

Samame, R. A.; Owens C. M.; Rychnovsky, S. D. Chem. Sci., 2015, DOI: 10.1039/C5SC03262H.

 

 

 

 

“A New In Vivo Cross-linking Mass Spectrometry Platform to Define Protein-Protein Interactions in Living Cells”

Kaake, R. M.; Wang, X.; Burke, A.; Yu, C.; Kandur, W.; Yang, Y.; Novitsky, E. J.; Second, T.; Duan, J.; Kao, A.; Guan, S.; Vellucci, D.; Rychnovsky, S. D.; Huang, L. Mol. Cell. Proteomics 2014, 13, 3533–3543.

 

 

“Developing New Isotope-coded MS-cleavable Cross-linkers for Elucidating Protein Structures”

Clinton Yu; Wynne Kandur; Athit Kao; Scott D. Rychnovsky; Lan Huang Anal. Chem. 2014, 86, 2099–2106.

 

 

“Undergraduate Laboratory Experiment To Determine Absolute Configuration Using Thin-Layer Chromatography” Wagner, A. J.; Miller, S. M.; Nguyen, S.; Lee, G. Y.; Rychnovsky, S. D.; Link, R. D. J. Chem. Ed., 2014, 91, 716–721.

 

 

"Studies Towards the Synthesis of Palhinine Lycopodium Alkaloids: A Morita–Baylis–Hillman/Intramolecular Diels–Alder Approach"

Nicholas Sizemore, Scott D. Rychnovsky, Org. Lett. 2014, 16, 688–691.

 

 

 

 

"Kinetic Analysis of the HBTM-Catalyzed Esterification of an Enantiopure Secondary Alcohol"

Alexander J. Wagner, Scott D. Rychnovsky, Org. Lett. 2013, 15, 5504–5507.

 

 

 

 

"Formation of Highly Substituted Tetrahydropyranones: Application to the Total Synthesis of Cyanolide A"

Gidget C. Tay, Scott D. Rychnovsky, Org. Lett. 2013, 15, 4536–4539.

 

 

 

 

"Trianion Synthon Approach to Spirocyclic Heterocycles"

Matthew A. Perry, Richard R. Hill, and Scott D. Rychnovsky, Org. Lett. 2013, 15, 2226-2229.

 

 

 

 

"Origins of Regio-and Stereochemistry in Type 2 Intramolecular N-Acylnitroso Diels–Alder Reactions: A Computational Study of Tether Length and Substituent Effects"

Leah Cleary, Victor W Mak, Scott D Rychnovsky, Kenneth J Shea, and Nicholas Sizemore, J. Org. Chem. 2013, 4090–4098.

 

 

 

 

"Determination of Absolute Configuration of Secondary Alcohols Using Thin-Layer Chromatography"

Alexander Wagner, Scott D. Rychnovsky, J. Org. Chem. 2013, 4594–4598.

 

 

 

 

"Absolute Configuration of Lactams and Oxazolidinones Using Kinetic Resolution Catalysts"

Matthew A. Perry , Jonathan V. Trinidad , and Scott D. Rychnovsky. Org. Lett. 2013, 472–475.

 

 

 

 

"Nanomole-scale Assignment of Configuration for Primary Amines Using a Kinetic Resolution Strategy"

Shawn M. Miller, Renzo A. Samame and Scott D. Rychnovsky, J. Am. Chem. Soc. 2012, 134, 20318-20321.

 

 

 

 

"Cholesterol through the looking glass: ability of its enantiomer to also elicit homeostatic responses."

Ika Kristiana, Winnie Luu, Julian Stevenson, Sian Cartland, Wendy Jessup, Jitendra D. Belani, Scott D. Rychnovsky and Andrew J. Brown, J. Biol. Chem. 2012, 287, 33897–33904.

 

 

"Mapping the Structural Topology of the Yeast 19S Proteasomal Regulatory Particle Using Chemical Cross-linking and Probabilistic Modeling"

Athit Kao, Arlo Randall, Yingying Yang, Vishal R. Patel, Wynne Kandur, Shenheng Guan, Scott D. Rychnovsky, Pierre Baldi, Lan Huang, Mol. Cell. Proteomics 2012, 1566–1577.

 

 

"Total Synthesis of Lepadiformine Alkaloids using N-Boc α-Amino Nitriles as Trianion Synthons"

Matthew A. Perry, Matthew D. Morin, Brian W. Slafer, and Scott D. Rychnovsky, J. Org. Chem. 2012, 77, 3390–3400.

 

 

 

 

"Discussion Addendum for: Preparation of α-Acetoxy Ethers by the Reductive Acetylation of Esters: endo-1-Bornyloxyethyl Acetate"

Nicholas Sizemore and Scott D. Rychnovsky, Org. Synth. 2012, 89, 143-158.

 

 

"Determination of Absolute Configuration Using Kinetic Resolution Catalysts."

Alexander J. Wagner, Jonathan G. David and Scott D. Rychnovsky, Org. Lett. 2011, 13, 4470-4473.

 

 

 

 

"DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions."

Maureen K. Reilly and Scott D. Rychnovsky, Synlett, 2011, 2392-2396.

 

 

"Total Synthesis of the Cyanolide A Aglycon."

Mike R. Gesinski and Scott D. Rychnovsky, J. Am. Chem. Soc. 2011, 133, 9727-9729.

 

 

 

 

"Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions."

Anna N. Bukiya, Jitendra D. Belani, Scott Rychnovsky, and Alex M. Dopico, J. Gen. Physiol. 2011, 137, 93-110.

 

 

"Allyl Transfer to Aldehydes and Ketones by Brønsted Acid Activation of Allyl and Crotyl 1,3,2-Dioxazaborolidines."

Maureen K. Reilly and Scott D. Rychnovsky, Org. Lett. 2010, 12, 4892-4895.

 

 

 

 

"Development of a Novel Cross-Linking Strategy for Fast and Accurate Identification of Cross-Linked Peptides of Protein Complexes."

Athit Kao, Chi-li Chiu, Danielle Vellucci, Yingying Yang, Shenheng Guan, Arlo Randall, Pierre Baldi, Scott D. Rychnovsky, Lan Huang, Mol. Cell. Proteomics. 2011, 10, 1-17.  (DOI: 10.1074/mcp.M110.002212)

 

 

"Fully Substituted Carbon Centers By Diastereoselective Spirocyclization: Stereoselective Synthesis of (+)-Lepadiformine C."

Matthew Perry, Matthew D. Morin, Brian W. Slafer, Scott A. Wolckenhauer and Scott D. Rychnovsky, J. Am. Chem. Soc. 2010, 132, 9591-9593 (DOI:10.1021/ja104250b).

 

 

 

 

"Selective Enrichment and Identification of Azide-tagged Cross-Linked Peptides Using Chemical Ligation and Mass Spectrometry."

Danielle Vellucci, Athit Kao, Robyn M. Kaake, Scott D. Rychnovsky, and Lan Huang, J. Am. Soc. Mass Spectrom. 2010, 21, 1432-1445.

 

 

"Total Synthesis of (–)-Lycoperine A."

Yoshitaka Nakamura, Anthony M. Burke, Shunsuke Kotani, Joseph W. Ziller and Scott D. Rychnovsky, Org. Lett. 2010, 12, 72-75.

 

 

 

 

"Symmetric Macrocycles by a Prins Dimerization and Macrocyclization Strategy."

Michael R. Gesinski, Kwanruthai Tadpetch, and Scott D. Rychnovsky, Org. Lett. 2009, 11, 5342-5345.

 

 

"Polyol Synthesis with β-Oxyanionic Alkyllithium Reagents: Syntheses of Aculeatins A, B and D."

Viengkham Malathong and Scott D. Rychnovsky, Org. Lett. 2009, 11, 4220-4223.

 

 

"Rhenium(VII) Catalysis of Prins Cyclization Reactions."

Kwanruthai Tadpetch and Scott D. Rychnovsky, Org. Lett. 2008, 10, 4839-4842.

 

 

"Cyclization via Carbolithiation of α-Amino Alkyllithium Reagents."

Robert J. Bahde and Scott D. Rychnovsky, Org. Lett. 2008, 10, 4017-4020.

 

 

"Formal Synthesis of (–)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle."

Kevin B. Bahnck and Scott D. Rychnovsky, J. Am. Chem. Soc. 2008, 130, 13177-13181.

 

 

"Assignment of Absolute Configuration to SCH 351448 via Total Synthesis."

Lael L. Cheung, Shinji Marumoto, Christopher D. Anderson and Scott D. Rychnovsky, Org. Lett. 2008, 10, 3101-3104.

 

 

"A Concise Synthesis of ent-Cholesterol."

Jitendra D. Belani and Scott D. Rychnovsky, J. Org. Chem. 2008, 73, 2768-2773.

 

 

"Lewis Acid-Promoted Mukaiyama Aldol–Prins (MAP) Cyclizations of Acetals, Ketals, α-Acetoxy Ethers, and Orthoformates."

Michael R. Gesinski, Lori J. Van Orden and Scott D. Rychnovsky, Synlett 2008, 363-366.

 

 

"Substrate Chirality and Specificity of Diacylglycerol Kinases and the Multisubstrate Lipid Kinase."

Richard M. Epand, Yulia V. Shulga, Heath C. Timmons, Alexandra L. Perri, Jitendra D. Belani, Laura Beth Johnson-McIntire, Sandra Bajjalieh, Armela O. Dicu, Cynthia Elias, Scott D. Rychnovsky, and Matthew K. Topham, Biochemistry, 2007, 46, 14225-14231.

 

 

"Synthesis of the C1-C52 Fragment of Amphidinol 3, Featuring a β-Alkoxy Alkyllithium Addition Reaction."

John R. Huckins, Javier de Vicente and Scott D. Rychnovsky, Org. Lett. 2007, 9, 4757-4760.

 

 

"Synthesis and Structural Reassignment of (+)-Epicalyxin F."

Xia Tian and Scott D. Rychnovsky, Org. Lett. 2007, 9, 4955-4958.

 

 

"Multidrug resistance protein 1 is not associated to detergent-resistant membranes."

Emilie Cerf, Régis Gasper, Scott Rychnovsky, Xiu-bao Chang Frédéric Buyse, and Jean-Marie Ruysschaert, Biochem. Biophys. Res. Commun. 2007, 355, 1025-1030.

 

 

"Total Synthesis of Leucascandrolide A: A New Application of the Mukaiyama Aldol-Prins Reaction."

Lori J. Van Orden, Brian D. Patterson, and Scott D. Rychnovsky, J. Org. Chem. 2007, 72, 5784-5793.

 

 

"A Reductive Cyclization Approach to Attenol A."

Thomas E. La Cruz and Scott D. Rychnovsky, J. Org. Chem. 2007, 72, 2602-2611.

 

 

"Diastereoselective Synthesis of the Pectenotoxin 2 Non-Anomeric AB Spiroacetal."

Danielle Vellucci and Scott D. Rychnovsky, Org. Lett. 2007, 9, 711-714.

 

 

"Qualitative and Quantitative Measurements of Hydrogen Bond-Mediated Scalar Couplings in Acyclic 1,3-Diols."

Nikolaus M. Loening, Carolyn E. Anderson, Wendy S. Iskenderian, Christopher D. Anderson, Scott D. Rychnovsky, Michael Barfield, and Daniel J. O’Leary,Org. Lett. 2006, 8, 5321-5323.

 

 

"Synthesis of the C31–C67 Fragment of Amphidinol 3."

Javier de Vicente, John R. Huckins, and Scott D. Rychnovsky, Angew. Chem., Int. Ed. 2006, 45, 7258-7262.

 

 

"Racemization in Prins Cyclization Reactions."

Ramesh Jasti and Scott D. Rychnovsky, J. Am. Chem. Soc. 2006, 128, 13640-13648.

 

 

"Total Synthesis and Structural Assignment of (+)-Hexacyclinol."

John A. Porco, Jr., Shun Su, Xiaoguang Lei, Sujata Bardhan, and Scott D. Rychnovsky, Angew. Chem., Int. Ed. 2006, 45, 5790-5792.

 

 

"Hexacyclinol Debate Heats Up" by Bethany Halford, Chem. Eng. News, July 31, 2006, p. 11.

 

 

"The Proof is in the Product" by Emma Marris, Nature 442, pp. 492-493 (3 August 2006).

 

 

"Predicting NMR Spectra by Computational Methods: Structure Revision of Hexacyclinol."

Scott D. Rychnovsky, Org. Lett. 2006, 8, 2895-2898.

 

 

"Computations cast doubt on chemical synthesis," Nature 441, p. 800 (15 June 2006).

 

 

"Solvolysis of a Tetrahydropyranyl Mesylate:  Mechanistic Implications for the Prins Cyclization, 2-Oxonia-Cope Rearrangement, and Grob Fragmentation."

Ramesh Jasti and Scott D. Rychnovsky, Org. Lett. 2006, 8, 2175-2178.

 

 

"Rapid Stereocontrolled Assembly of the Fully Substituted C-Aryl Glycoside of Kendomycin with a Prins Cyclization:  A Formal Synthesis."

Kevin B. Bahnck and Scott D. Rychnovsky, Chem. Commun. 2006, 2388-2390.

 

 

"Synthesis and Structure Revision of Calyxin Natural Products."

Xia Tian, James J. Jaber and Scott D. Rychnovsky, J. Org. Chem. 2006, 71, 3176-3183.

 

 

"Stereoselectivity of Intramolecular SN´ Cyclizations of Alkyllithium Reagents on Methoxy Alkenes."

Thomas E. La Cruz and Scott D. Rychnovsky, J. Org. Chem. 2006, 71, 1068-1073.