Kaitocephalin Antagonism of Glutamate Receptors Expressed in Xenopus Oocytes
Limon, A.; Reyes-Ruiz, J. M.; Vaswani, R. G.; Chamberlin, A. R.; Miledi, R. ACS Chem. Neurosci. 2010, 1, 175–181
Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (–)-kaitocephalin
Vaswani, R. G.; Limon, A.; Reyes-Ruiz, J. M.; Miledi, R.; Chamberlin, A. R. Bioorg. Med. Chem. Lett. 2009, 19, 132–135
Methods for the Chemical Synthesis of Noncoded a-Amino Acids Found in Natural Product Peptides
Habay, S. A.; Park, S. S.; Kennedy, S. M.; Chamberlin, A. R.,
Amino Acids, Peptides and Proteins in Organic Chemistry:Vol1-Origins and Synthesis of Amino Acids, Andrew B. Hughes (ed.), Wiley-VCH, 2009, pp. 163-244.
Stereoselective Synthesis of Chiral IBR2 Analogues
Qiu, X. L.; Zhu, J.; Wu, G.; Lee, W. H.; Chamberlin, A. R. J. Org. Chem. 2009, 74, 2018–2027
Synthesis and Biological Evaluation of a Series of Novel Inhibitor of Nek2/Hec1 Analogues
Qiu, X. L.; Li, G.; Wu, G.; Zhu, J.; Zhou, L.; Chen, P. L.; Chamberlin, A. R.; Lee, W. H. J. Med Chem. 2009, 52, 1757–1767
Synthesis and pharmacological in vitro and in vivo profile of SHA 68 (3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide), a selective antagonist of the Neuropeptide S receptor
Okamura, N.; Habay, S. A.; Zeng, J.; Chamberlin, A. R.; Reinscheid, R. K. Journal of Pharmacology and Experimental Therapeutics, 2008, 325(3), 893-901.
Activation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme's Regulatory Site
Tappan, E.; Chamberlin, A.R. Chemistry and Biology, 2008, 15, 167-174.
Stereocontrolled Total Synthesis of (-)-Kaitocephalin
Vaswani, R.G.; Chamberlin, A.R. J. Org. Chem., 2008, 73(5), 1661-1681.
Diastereoselective Synthesis of Glutamate-Appended Oxolane Rings: Synthesis of (S)-(+)-Lycoperdic Acid.
Cohen, J.L.; Chamberlin, A.R. J. Org. Chem., 2007, 72(24), 9240-9247.
Synthesis of the dysiherbaine tetrahydropyran core employing a tethered aminohydroxylation reaction.
Cohen, J.L.; Chamberlin, A.R. Tet. Lett., 2007, 48, 2533-2536
Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase.
Charvat, T. T.; Lee, D. J.; Robinson, W. E.; Chamberlin, A. R. Bioorg. Med. Chem., 2006, 14(13), 4552-4567
Pharmacophore Identification: The Case of the Ser/Thr Protein Phosphatase Inhibitors.
Colby, D.A.; Chamberlin, A.R. Mini-Reviews in Medicinal Chemistry, 2006, 6(6), 657-665.
A Central Strategy for Converting Natural Products into Fluorescent Probes.
Alexander, M. D.; Burkart, M. D.; Leonard, M.l S.; Portonovo, P.; Liang, B.; Ding, X.; Joullie, M. M.; Gulledge, B.M.; Aggen, J. B.; Chamberlin, A. R.; Sandler, J.; Fenical, W.; Cui, J.; Gharpure, S. J.; Polosukhin, A.; Zhang, H.; Evans, P. A.; Richardson, A. D.; Harper, M. K.; Ireland, C.M.; Vong, B. G.; Brady, T. P.; Theodorakis, E. A.; La Clair, J. J. ChemBiochem., 2006, 7(3), 409-416.
Design, Synthesis and Biological Evaluation of a Scaffold for iGluR Ligands Based on the Structure of (-)-Dysiherbaine.
Cohen, J.L.; Limon, A.; Miledi, R.; Chamberlin, A.R. Bioorg. Med. Chem. Lett., 2006, 16(8), 2189-2194.
The substituted aspartate analogue L-B-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3.
Esslinger, C. S.; Agarwal, S.; Gerdes, J.; Wilson, P. A.; Davis, E. S.; Awes, A. N.; O'Brien, E.; Mavencamp, T.; Koch, H. P.; Poulsen, D.J.; Rhoderick, J. F.; Chamberlin, A. R.; Kavanaugh, M.P.; Bridges, R. J. Neuorpharmacology, 2005, 49(6), 850-861.
Fluorescent Profiling of Natural Product Producers.
Sandler, J.S., Fenical, W., Gulledge, B.M., Chamberlin, A.R., La Clair, J.J. J. Am. Chem. Soc. 2005, 127, 9320-9321.
Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors.
Shou, X., Miledi, R., Chamberlin, A.R. Bioorg. Med. Chem. Lett. 2005, 15, 3942-3947.
Modified norcantharidins synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.
Hart, M.E., Chamberlin, A.R., Walkom, C., Sakoff, J.A., McCluskey, A. Bioorg. Med. Chem. Lett. 2004, 14, 1969-1973.
Ligands for kainate subtype glutamate receptors.
Shou, X., Chamberlin, A.R. Expert Opinion on Therapeutic Patents 2004, 14, 471-486.
Bridging the Synthetic and Biopolymer Worlds with Peptide-Drug Conjugates
Weiss, G.A.; Chamberlin, R. Chem. Biol., 2003, 10(3), 201-202.
'Linearized' and Truncated Microcystin Analogues as Inhibitors of PP1 and PP2A.
Gulledge B.M., Aggen J.B., Huang H.-B., Nairn A.C., Chamberlin A.R. Bioorg. Med. Chem. Lett. 2003, 13, 2903-2906.
Microcystin Analogues Comprised Only of Adda and a Single Additional Amino Acid Retain Moderate Activity as PP1/PP2A Inhibitors.
Gulledge B.M., Aggen J.B., Eng H., Sweimeh K., Huang H.-B., Nairn A.C., Chamberlin, A.R. Bioorg. Med Chem. Lett. 2003, 13, 2907-2911.
A New Model of the Tautomycin-PP1 Complex That Is Not Analogous to the Corresponding Okadaic Acid Structure.
Colby D.A., Liu W., Sheppeck J.E. Jr., Huang H.-B., Nairn A.C., Chamberlin A.R. Bioorg. Med. Chem. Lett. 2003, 13, 1601-1605.
Selective Inhibition of Phosphatases by Natural Toxins: the Anhydride Domain of Tautomycin is Not a Primary Factor in Controlling PP1/PP2A Selectivity.
Liu W., Sheppeck J.E. Jr., Colby D.A., Huang H.-B., Nairn A.C., Chamberlin A.R. Bioorg. Med. Chem. Lett. 2003, 13, 1597-1600.
Effects of 5'-alkyl-benzothiadiazides on AMPA receptor biophysics and synaptic responses.
Arai A.C., Xia Y.-F., Kessler M., Phillips D., Chamberlin A.R. Mol. Pharm. 2002, 62, 566-577.
Synthesis of DNA-binding Polyamides: Robust Solid-phase Methods for Coupling Heterocyclic Aromatic Amino Acids.
Krutzik P.O., Chamberlin A.R. In Combinatorial Library Methods and Protocols, Methods in Molecular Biology; English, L.B. Ed.; Humana: Totowa, NJ, 2002; Ch. 6.
Rapid Solid-phase Synthesis of DNA-binding Pyrrole-imidazole Polyamides.
Krutzik P.O., Chamberlin A.R. Bioorg. Med. Chem. Lett. 2002, 12, 2129-2132.
Methylation of L-trans-2,4-Pyrrolidine Dicarboxylate Converts the Glutamate Transport Inhibitor from a Substrate to a Non-substrate Inhibitor.
Esslinger C.S., Titus J.L., Koch H.P., Bridges R.J., Chamberlin A.R. Bioorg. Med. Chem. 2002, 10, 3509-3515.
Increasing Rates of Reaction: Microwave-assisted Organic Synthesis for Combinatorial Chemistry.
Lew A., Krutzik P.O., Hart M.E., Chamberlin A.R. J. Comb. Chem. 2002, 4, 95-105.
Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker.
Lew A., Chamberlin A.R. In Combinatorial Library Methods and Protocols, Methods in Molecular Biology; English, L.B. Ed.; Humana: Totowa, NJ, 2002; Ch.7.
The Microcystins and Nodularins: Cyclic Polypeptide Inhibitors of PP1 and PP2A.
Gulledge B., Aggen J.B., Huang H.-B., Nairn A.C., Chamberlin A.R. Curr. Med. Chem. 2002, 9, 1991-2003.
Total Synthesis of Dysiherbaine.
Phillips D, Chamberlin A.R. J. Org. Chem. 2002, 67, 3194-3201.
5'-Alkyl-benzothiadiazides: A New Subgroup of AMPA Receptor Modulators with Improved Affinity.
Phillips D., Sonnenberg J., Arai A.C., Vaswani R., Krutzik P., Kleisli T., Kessler M., Granger R., Lynch G., Chamberlin A.R. Bioorg. Med. Chem. 2002, 10, 1229-1248.
A Congener-independent Immunoassay for Microcystins and Nodularins.
Fischer W.J., Garthwaite I., Miles C.O., Ross K.M., Aggen J.B., Chamberlin A.R., Towers N.R., Dietrich D.R. Environ. Sci. Tech. 2001, 35, 4849-4856.
Differing Effects of Substrate and Non-substrate Transport Inhibitors on Glutamate Uptake Reversal.
Anderson C.M., Bridges R.J., Chamberlin A.R., Shimamoto K., Yasuda-Kamatani Y., Swanson R.A. J. Neurochem. 2001, 79, 1207-1216.
Human T-cell Kv1.3 Potassium Channel Blockers: New Strategies for Immunosuppression.
Lew A., Chamberlin A.R. Exp. Opin. Ther. Patents 2000, 10, 905-913.
The Regulation of Protein Phosphatase 1 Activity.
Aggen J.B., Nairn A., Chamberlin A.R. Chem. Biol. 2000, 7, R13-R23.
Differentiation of Substrate and Non-Substrate Inhibitors of the High-Affinity, Sodium-dependent Glutamate Transporters.
Koch H.P., Kavanaugh M.P., Esslinger C.S., Zerangue N., Humphrey J.M., Amara S.G., Chamberlin A.R., Bridges R.J. Mol. Pharm. 1999, 56, 1095-1104.
A Pharmacological Review of Competitive Inhibitors and Substrates of High-affinity, Sodium-dependent Glutamate Transport in the Central Nervous System.
Bridges R.J., Kavanaugh M., Chamberlin A.R. Curr. Pharm. Design 1999, 5, 363-379.
Blockers Of Human T Cell Kv1.3 Potassium Channels Using De Novo Ligand Design and Solid Phase Combinatorial Chemistry.
Lew A., Chamberlin A.R. Bioorg. Med. Chem. Lett. 1999, 9, 3267-3272.
Incorporation of Noncoded Amino Acids by In Vitro Protein Biosynthesis.
Gilmore M., Steward L., Chamberlin A.R. Top. Current Chem. 1999, 202, 77-99.
Non-Transportable Inhibitors Attenuate the Reversal of Glutamate Uptake in Synaptosomes Following Metabolic Insult.
Koch H.P., Chamberlin A.R., Bridges R.J. Mol. Pharm. 1999, 55, 1044-1048.
The Design, Synthesis, and Biological Evaluation of Analogs of the Serine-threonine Protein Phosphatase 1 and 2A Selective Inhibitor Microcystin LA: Rational Modifications Imparting PP1 Selectivity.
Aggen J.B., Gauss C.-M., Huang H.-B., Nairn A.C., Chamberlin A.R. Bioorg. Med. Chem. 1999, 7, 543-564.
Structural Determinants of Substrates and Inhibitors: Probing Glutamate Transporters with 2,4-Methano-2,4-Pyrrolidine Dicarboxylate.
Esslinger C.S., Koch H.P., Kavanaugh M.P., Phillips D.P., Chamberlin A.R., Thompson C.M., Bridges R.J., Bioorg. Med. Chem. Lett. 1998, 8, 3101-3106.
Design and Synthesis of Conformationally Constrained Inhibitors of the High-Affinity, Sodium-Dependent Glutamate Transporters.
Chamberlin A.R., Koch H.P., Bridges R.J. Methods Enzymol. 1998, 296, 175-188.
Protein Engineering with Non-standard Amino Acids.
Steward, L., Chamberlin, A.R., Methods in Molecular Biology: Protein Synthesis Methods and Protocols, 1998, 77, 325-354.
A Molecular Modeling Analysis of Binding Interactions Between the Okadaic Acid Class of Natural Product Inhibitors and the Serine-threonine Phosphatases, PP1 and PP2A.
Gauss, C. M.; Sheppeck, J.; Nairn, A. C.; Chamberlin, A. R. Bioorg. Med. Chem. 1997, 5, 1751-1773.
Chemical Synthesis of Peptide Natural Products Containing Non-coded Amino Acids.
Humphrey J.M., Chamberlin A.R. Chem. Rev. 1997, 97, 2243.
Irreversible Inhibition of High-Affinity 3H-Kainate Binding by a Novel Photoactivatable Analogue: ((2'S,3'S,4'R)-2'-Carboxy 4'-(2-diazo-1-oxo-3,3,3-trifluoropropyl) 3'-pyrrolidinylacetate.
Willis, C.L.; Wacker, D.A.; Bartlett, R.D.; Bleakman, D.; Lodge, D.; Chamberlin, A.R.; and Bridges, R.J. J. Neurochem.1997, 68, 1503-1510.
In Vitro Incorporation of Fluorescent Probes into b-Galactosidase.
Steward, L., Collins, C.S.; Gilmore, M.; Carlson, J; Ross, J.B.A. Ross; Chamberlin, A.R. J. Am. Chem. Soc.1997, 119, 6-11.
Inhibition of the Ser-Thr Phosphatases PP1 and PP2A by Naturally Occurring Toxins.
Gauss, C. M.; Sheppeck, J.; Chamberlin, A. R. Bioorg. Med. Chem.1997, 5, 1739-1750.
Methylation of the NMDA receptor agonist L-trans-2,3-Pyrrolidine-Dicarboxylate: Enhanced excitotoxic potency and selectivity.
Willis, C. L.; Humphrey, J. M.; Dauenhauer, D.; Chamberlin, A. R.; Bridges, R. J.; Toxicol. App. Pharmacol. 1997, 144, 45-55.
Synthesis of the Serine-threonine-specific Phosphatase Inhibitor Tautomycin.
Sheppeck, J.; Liu, W.; Chamberlin, A. R. J. Org. Chem. 1997, 62, 387-398.
A Selective Photoaffinity Ligand for the Kainate Class of Excitatory Amino Acid Receptor.
Wacker, D.; Lovering, F.; Bridges, R.J.; Chamberlin, A.R. Synlett (E. J Corey Special Issue) 1997, 5, 503-504.
Total Synthesis of the Serine-Threonine Phosphatase Inhibitor Microcystin LA.
Humphrey, J. H.; Aggen, J.; Chamberlin, A. R. J. Am. Chem. Soc.1996, 118, 11759-11770.
The Role of the C-4 side Chain of Kainate and Dihydrokaninate in EAA Receptorand Transporter Selectivity.
Bridges, R. J.; Sonnenberg, J.; Blakely, T.; Koch, H.; Ho, S.; Chamberlin, A.R. Bioorg. Med. Chem. Lett.1996, 6, 1607-1612.
L-trans-2,3-Pyrrolidine Dicarboxylate: A Novel Excitotoxin.
Willis, C. L.; Humphrey, J. M.; Koch, H.P.; Hart, J. A.; Blakely, T.; Ralston, L.; Baker, C. A.; Shim, S.; Kadri, M.; Chamberlin, A.R. Bridges, R. J. Neuropharmacology 1996, 35 , 531.
Protein Expression by Expansion of the Genetic Code.
Steward, L., Chamberlin, A.R., The Encyclopedia of Molecular Biology and Molecular Medicine, 1996, 135-147.
Efficient Synthesis of Diastereoselectively Labeled (3S)-[4-13C]-L-Valine and Regioselectively Labeled (3-13CH3)-L-Isoleucine Hydrochlorides.
Humphrey, J. M.; Hart, J. A.; Chamberlin, A.R. Bioorg. Med. Chem. Lett. 1995, 5, 1315-1320.
Enantiomerically Pure g-Butyrolactones in Natural Products Synthesis.
Canan Koch, S.; Chamberlin, A. R., in Studies in Natural Products Chemistry, Atta-ur-Rahman (ed.), Elsevier, 1995, pp. 687-726.
2,4-Dinitrobenzene-sulfonylhydrazide, Mesitylenesulfonylhydrazide, Mesitylenesulfonylhydroxylamine,p-Tolylsulfonylhydrazide, and 2,4,6-Triisopropylbenzenesulfonylhydrazide.
Sheppeck, James E., II; Chamberlin, A.R., in Encyclopedia of Reagents for Organic Synthesis, L. Paquette, (ed.) J. Wiley & Sons, 1995.
N-Amino-aziridinylhydrazones: Highly Diastereoselective Alkylation without Chelation, and a Syn-directing Effect.
Augeri, D. J.; Chamberlin, A. R. Tetrahedron Lett. 1994, 35, 5599-5602.
Pharmacological Dissociation of Glutamtergic Metabotrobic Signal Transduction Pathways in Cortical Astrocytes.
Miller, S.; Bridges, R. J.; Chamberlin, A. R.; Cotman, C. W. Europ. J. Pharm. 1994, 269, 235-241.
Enantioselective and Diastereoselective Molecular Recognition of Cyclic Dipeptides by a C2 Macrolactam Host.
Cristofaro, M. F,.; Chamberlin, A. R. J. Am. Chem. Soc. 1994, 116, 5089-5098.
A Conformationally Constrained Competitive Inhibitor of the Sodium-dependent Glutamate Transporter in Forebrain Synaptosomes: L-anti-endo-methanopyrrolidine Dicarboxylate.
Bridges, R.J.; Lovering, F.; Koch, H.; Cotman, C. W.; Chamberlin, A.R. Neurosci. Lett.1994, 174, 193-197.
2,3-Pyrrolidine Dicarboxylates as Neurotransmitter Conformer Mimics. Enantioselective Synthesis via Chelation-controlled Enolate Alkylation.
Humphrey, J. M.; Bridges, R. J.; Hart, J. A.; Chamberlin, A.R. J. Org. Chem. 1994, 59, 2467-2472.
Conformationally Constrained Acidic Amino Acids as Probes of Glutamate Receptors and Transporters.
Chamberlin, A. R.; Bridges, R. J. Drug Design for the Neurosciences (A. P. Kozikowski, ed.), 1993: Raven Press, pp. 231-259.
Enantioselective Preparation of b-Alkyl-g-butryrolactones from Functionalized Ketene Dithioacetals.
Canan Koch, S.; Chamberlin. A. R. J. Org. Chem. 1993, 58, 2725.
Conformationally Restricted Inhibitors of the High Affinity L-Glutamate Transporter.
Bridges, R. J.; Lovering, F. J.; Humphrey, J. M., Stanley, M. S.; Blakely, T. N.; Cristofaro, M.; Chamberlin, A.R. Bioorg. Med. Chem. Lett. (Symposium-in-Print: Excitatory Amino Acids) 1993, 3, 115-121.
Ribosome-mediated Incorporation of Non-standard Amino Acids into a Peptide through Expansion of the Genetic Code.
Bain, J.D.; Switzer, C.; Benner, S.A.; Chamberlin, A.R. Nature 1992, 356, 537.
Reduction of Ketones to Alkenes.
Chamberlin, A. R.; Sall, D. J. Comprehensive Organic Reactions, 1991, Volume 8, p. 923.
Site-specific Incorporation of Non-natural Residues into Peptides: Effect of Residue Structure on Suppression and Translation Efficiencies.
Bain, J.D.; Wacker, D.A.; Kuo, E.E.; Chamberlin, A.R. Tetrahedron (Symposium-in-Print: Recent Advances in Bioorganic Chemistry) 1991, 47, 2389.
Lithium Aluminum Hydride Reduction of N-Aziridinylimines to Hydrocarbons.
Leone, C.; Chamberlin, A. R. Tetrahedron Lett. 1991, 32, 1691.
Stereochemical Control in Reactions of Nucleophiles with Oxocarbenium Ions Formed by Intramolecular Opening of Activated Epoxides by Neighboring Carbonyl Groups.
Fotsch, C. F.; Chamberlin, A. R. J. Org. Chem. 1991, 56, 4141.
New Nucleoside Phosphoramidites and Coupling Protocols for Solid-Phase RNA Synthesis.
Lyttle, M.H.; Wright, P.B.; Sinha, N.D.; Bain, J.D.; Chamberlin, A.R. J. Org. Chem. 1991, 56, 4608.
Preparation of Chemically Misacylated Semi-synthetic Nonsense Suppressor tRNAs Employed in Biosynthetic Incorporation of Non-natural Residues into Proteins.
Bain, J. D.; Wacker, D.A.; Kuo, E.; Lyttle, M. H.; Chamberlin, A. R. J. Org. Chem. 1991, 56, 4615.
Conformationally Defined Neurotransmitter Analogues. Selective Inhibition of Glutamate Uptake by One Pyrrolidine-2,4-dicarboxylate Diastereomer.
Bridges, R.; Stanley, M.S.; Anderson, M. W.; Cotman, C.; Chamberlin, A. R. J. Med. Chem. 1991, 34, 717-725.
Site-specific Incorporation of Non-natural Residues during In Vitro Protein Biosynthesis with Semi-synthetic Aminoacyl tRNAs.
Bain, J. D.; Diala, E. S.; Glabe, C. G.; Wacker, D. A.; Lyttle, M. H.; Dix, T. A.; Chamberlin, A. R. Biochemistry 1991, 30, 5411.
Enantiomerically Pure Polyhydroxylated Acyliminium Ions: Synthesis of the Glycosidase Inhibitors (-)-Swainsonine and (+)-Castanospermine.
Miller, S. A.; Chamberlin, A. R. J. Am. Chem. Soc. 1990, 112, 8100.
Regioselective Synthesis of Substituted Rubrenes.
Dodge, Jeffrey, A.; Bain, J. D.; Chamberlin, A. R. J. Org. Chem. 1990, 55, 4190.
Lithioalkenes from Arenesulfonylhydrazones.
Chamberlin, A.R.; Bloom, S.H. Organic Reactions 1990, 39, 1.
Biosynthetic Site-specific Incorporation of a Non-natural Amino Acid into a Polypeptide.
Bain, J. D.; Diala, E. S.; Glabe, C. G.; Dix, T. A.; Chamberlin, A. R. J. Am. Chem.Soc. 1989, 111, 8013.
Highly Selective Formation of Cis-Substituted Hydroxylactams via Auxiliary-Controlled Reduction of Imides.
Miller, S. A.; Chamberlin, A. R.; J. Org Chem. 1989, 54, 2502.
Enantioselective Total Synthesis of 9-S-Dihydroerythronolide A Seco Acid.
Chamberlin. A. R.; Dezube, M.; Reich, S. H.; Sall, D. J. J. Am Chem. Soc. 1989, 111, 6247.
Modified Conditions for Efficient Baeyer-Villiger Oxidation with m-CPBA.
Chamberlin, A. R.; Canan-Koch, S. S. Synth. Commun. 1989, 19, 829.
Competitive Dienone-Phenol Type Rearrangements for the Regioselective Preparation of 2,4-Disubstituted-Naphth-1-ols.
Chamberlin, A.R.; Dodge, J. Tetrahedron Lett. 1988, 29, 4827.
Synthesis and Rotational Barriers of Aryl-Substituted Napthacene Systems: Framework for a Receptor Model.
Chamberlin, A.R.; Dodge, J. Tetrahedron Lett. 1988, 29, 1359.
Vinyllithium Cyclizations with Unactivated Alkenes as Internal Electrophiles. Stereoselective Formation of Substituted Methylene Cyclopentanes.
Chamberlin, A.R.; Bloom, S.H.; Cervini, L. A.; Fotsch, C. H. J. Am. Chem. Soc. 1988, 110, 4788.
Stereochemical Control in the Synthesis of 2,5-Di-substituted Tetrahydrofurans.
Mulholland, R.L.; Chamberlin, A.R. J. Org. Chem. 1988, 53, 1082.
Modeling Chemical Reactivity. The Effect of a Change in Rate-Limiting Step on the Stereoselectivity of Electrophilic Addition to Allylic Alcohols and Related Chiral Alkenes.
Chamberlin, A.R.; Mulholland, R.L., Jr.; Kahn, S.D.; Hehre, W.J. J. Am. Chem. Soc. 1987, 109, 672.
Modeling Chemical Reactivity. Regio- and Stereochemistry of Electrophilic Additions to Allylic Double Bonds.
Kahn, S.D.; Pau, C.F.; Chamberlin, A.R.; Hehre, W.J. J. Am. Chem. Soc. 1987, 109, 650.
Stereoselective Formation of the Hydrindane Ring System by Anionic Olefin Cyclization. Trapping of the Alkyllithium Intermediate with Electrophiles.
Chamberlin, A.R.; Bloom, S.H. Tetrahedron Lett. 1986, 27, 551.
Formation and Lithiation of 2-Bromo Ketene Dithioacetals.
Chamberlin, A.R.; Nguyen, H. J. Org. Chem. 1986, 51, 940.
Enantioselective Synthesis of Seven Pyrrolizidine Diols from a Single Precursor.
Chamberlin, A.R.; Chung, J.Y.L. J. Org. Chem.1985, 50, 4425.
Stereoselective Acyclic Enolate Formation via Conjugate Reduction: Correlation with Enone Conformational Preference.
Chamberlin, A.R.; Reich, S. J. Am. Chem. Soc. 1985, 107, 1440.
Cyclizations of Alkenyllithium Reagents.
Chamberlin, A.R.; Bloom, S.H. Tetrahedron Lett. 1984, 25, 4901.
Cationic Cyclizations of Ketene Dithioacetals. A General Synthesis of Pyrrolizidine, Indolizidine, and Quinolizidine Alkaloid Ring Systems. Chamberlin, A.R.; Nguyen, H.; Chung, J.Y.L. J. Org. Chem. 1984, 49, 1682.
Stereo- and Regioselectivity in Iodo Diol Formation from Acyclic Allylic Alcohols.
Chamberlin, A.R.; Mulholland, R.L., Jr. Tetrahedron (Symposium in Print) 1984, 40, 2297.
Iodocyclization of Allylic Alcohol Derivatives Containing Internal Nucleophiles. Control of Stereoselectivity by Substituents in the Acyclic Precursors.
Chamberlin, A.R.; Dezube, M.; Dussault, P.; McMills, M. J. Am. Chem. Soc. 1983, 105, 5819.
Characterization of 2-Amino-4-Phosphonobutyric Acid Binding to Rat Brain Membranes: A Selective Ligand for the Chloride-Dependent Class of L-Glutamate Binding Sites.
Monaghan, D.T.; Fagg, G.; Mena, E.; McMills, M.; Chamberlin, A.R.; Cotman, C.W. Brain Research 1983, 278, 137.
Synthesis of Optically Active Pyrrolizidine Diols. (+) - Heliotridine.
Chamberlin, A.R.; Chung, J.Y.L. J. Am. Chem. Soc. 1983, 105, 3653.
Generation and Reactions of Vinyllithium Reagents.
Chamberlin, A.R.; Liotta, E.L.; Bond, F.T. Organic Synthesis 1983, 61, 141.
Stereoselective Methylation of beta-Hydroxylactone Dianions.
Chamberlin, A.R.; Dezube, M. Tetrahedron Lett. 1982, 23, 3055.
The Ketenethioacetal Group as a Cationic Cyclization Terminator. A Synthesis of the Pyrrolizidine Ring System.
Chamberlin, A.R.; Chung, J.Y.L. Tetrahedron Lett. 1982, 23, 2619.
Stereoselective Acyclic Iodolactonization of Unsaturated 3-Hydroxyacids.
Chamberlin, A.R.; Dezube, M.; Dussault, P. Tetrahedron Lett. 1981, 22, 4611.
Total Synthesis of Maytansine.
Corey, E.J.; Weigel, L. Chamberlin, A.R.; Cho, H.; Hua, D.H. J. Am. Chem. Soc. 1980, 102, 6613.
Total Synthesis of (-)-N-Methylmaysenine.
Corey, E.J.; Weigel, L.O.; Chamberlin, A.R.; Lipshutz, B.H. J. Am. Chem. Soc. 1980, 102, 1439.
Regiochemical Control in Alkenyllithium Generation from Arenesulfonylhydrazones.
Chamberlin, A.R.; Bond, F.T. Synthesis 1979, 44.
Leaving Group Variation in Aprotic Bamford-Stevens Carbene Generation.
Chamberlin, A.R.; Bond, F.T. J. Org. Chem. 1978, 43, 154.
Vinyllithium Reagents from Arenesulfonylhydrazones.
Chamberlin, A.R.; Stemke, J.E.; Bond, F.T. J. Org. Chem. 1978, 43, 147.
A Convenient Route to Vinyllithium Reagents.
Stemke, J.E.; Chamberlin, A.R.; Bond, F.T. Tetrahedron Lett. 1976, 17(34), 2947.
Methotrexate.
Chamberlin, A.R.; Cheung, A.P.K.; Lim, P. in Analytical Profiles of Drug Substances, K. Florey, ed. Vol. 5, Academic Press, San Francisco, 1976, pp. 283-306.
contact website administrator
