THE NOWICK RESEARCH GROUP

Selected Publications

Transmembrane Proteins: Amyloids Hidden in Plain Sight?

Truex, N.L.; Nowick, J. S.

Biochemistry 2017, 56, 4735-4736. pdf html

 

 

A Tetramer Derived from Islet Amyloid Polypeptide

Wang, Y.; Kreutzer, A. G.; Truex, N.L.; Nowick, J. S.

J. Org. Chem. 2017, 82, 7905-7912. pdf html SI

 

PDB: 5UHR

 

X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–22

Salveson, P. J.; Spencer, R. K.; Kreutzer, A. G.; Nowick, J. S.

Org. Lett. 2017, 19, 3462-3465. pdf html SI

 

PDB: 5V63 5V64 5V65

 

X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16–22

Chen, K. H.; Corro, K. A.; Le, S. P.; Nowick, J. S.

J. Am. Chem. Soc. 2017, 139, 8102-8105. pdf html SI

 

PDB: 5VF1

 

X-ray Crystallographic Structure of a Teixobactin Analogue Reveals Key Interactions of the Teixobactin Pharmacophore

Yang, H.; Du Bois, D. R.; Ziller, J. W.; Nowick, J. S.

Chem. Commun. 2017, 53, 2772-2775. pdf html SI cif

 

 

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

Kreutzer, A. G.; Yoo, S.; Spencer, R. K.; Nowick, J. S.

J. Am. Chem. Soc. 2017, 139, 966-975. pdf html SI

 

PDB: 5SUR 5SUS 5SUT 5SUU

 

Assembly of Peptides Drived from β-Sheet Regions of β-Amyloid

Truex, N. L.; Wang, Y.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 13882-13890. pdf html SI

 

Coassembly of Peptides Drived from β-Sheet Regions of β-Amyloid

Truex, N. L.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 13891-13900. pdf html SI

 

Square channels formed by a peptide derived from transthyretin

Yoo, S.; Kreutzer A. G.; Truex, N. L.; Nowick, J. S.

Chem. Sci. 2016, 7, 6946-6951. pdf html SI

 

PDB: 5HPP

Elucidation of the Teixobactin Pharmacophore

Yang, H.; Chen, K. H.; Nowick, J. S.

ACS Chem. Biol. 2016, 11, 1823-1826. pdf html SI

X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin

Kreutzer, A. G.; Hamza, I. L.; Spencer, R. K.; Nowick, J. S.

J. Am. Chem. Soc. 2016, 138, 4634-4642. pdf html SI

 

PDB: 5HOW 5HOX 5HOY

Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins

Morse, R. P.; Willett, J. L. E.; Johnson, P. M.; Zheng, J.; Credali, A.; Iniguez, A.; Nowick, J. S.; Hayes, C. S.; Goulding. C. W.

J. Mol. Biol. 2015, 427, 3766-3784. pdf html SI

 

PDB: 4ZQU 4ZQV 4ZQW

X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin

Spencer, R. K.; Kreutzer, A. G.; Salveson, P. J.; Li, H.; Nowick, J. S.

J. Am. Chem. Soc. 2015, 137, 6304-6311. pdf html SI

 

PDB: 4P4V 4P4W 4P4X 4P4Y 4P4Z 4WC8 4X0S

A Newcomer’s Guide to Peptide Crystallography

Spencer, R. K.; Nowick, J. S.

Israel J. Chem. 2015, 55, 698-710. pdf html

 

A Fibril-like Assembly of Oligomers of a Peptide Derived from β-Amyloid

Pham, J. D.; Spencer, R. K.; Chen, K. H.; Nowick, J. S.

J. Am. Chem. Soc. 2014, 136, 12682-12690. pdf html SI

 

PDB: 4Q8D

Polymorphism of Oligomers of a Peptide from β-Amyloid

Pham, J. D.; Demeler, B.; Nowick, J. S.

J. Am. Chem. Soc. 2014, 136, 5432–5442. pdf html SI

Mechanism of IAPP Amyloid Fibril Formation Involves an Intermediate with a Transient β-Sheet

Buchanan, L. E.; Dunkelberger, E. B.; Tran, H. Q.; Cheng, P.-N.; Chiu, C.-C.; Cao, P.; Raleigh, D. P.; de Pablo, J. J.; Nowick, J. S.; Zanni, M. T.

Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19285-19290. pdf html

Structures of Oligomers of a Peptide from β-Amyloid

Pham, J. D.; Chim, N.; Goulding, C. W.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 12460-12467. pdf html SI

 

PDB: 4IVH

Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences

Spencer, R.; Chen, K. H.; Manuel, G.; Nowick, J. S.

Eur. J. Org. Chem. 2013, 3523-3528. pdf html SI

A Hydrophobic Surface is Essential to Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

Zheng, J.; Baghkhanian, A. M.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 6846-6852. pdf html SI

The Supramolecular Chemistry of β-Sheets

Cheng, P.-N.; Pham, J. D.; Nowick, J. S.

J. Am. Chem. Soc. 2013, 135, 5477–5492. pdf html

 

Amyloid β-Sheet Mimics that Antagonize Protein Aggregation and Reduce Amyloid Toxicity

Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg, D.; Nowick, J. S.

Nat. Chem. 2012, 4, 927-933. pdf html SI

 

PDB: 3T4G

Out-of-Register β-Sheets Suggest a Pathway to Toxic Amyloid Aggregates

Liu, C.; Zhao, M.; Jiang, L.; Cheng,P.-N.; Park, J.; Sawaya M.R.; Pensalfini, A.; Gou, D.; Berk A. J.; Glabe C. G.; Nowick, J. S.; Eisenberg. D.

Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 20913-20918. pdf html SI

 

PDB: 4E0K 4E0L 4E0M 4E0N 4E0O

Heterodivalent Linked Macrocyclic β-Sheets with Enhanced Activity against Aβ Aggregation: Two Sites are Better than One

Cheng, P.-N.; Spencer, R.; Woods, R. J.; Glabe, C. G.; Nowick, J. S.

J. Am. Chem. Soc. 2012, 133, 14179-14184. pdf html SI

Giant Macrolactams Based on β-Sheet Peptides

Cheng,P.-N.; Nowick, J. S.

J. Org. Chem. 2011, 76, 3166-3173. pdf html SI

Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D.

J. Am. Chem. Soc. 2011, 133, 6736-6744. pdf html SI

 

PDB: 3Q9G 3Q9H 3Q9I 3Q9J

Macrocyclic β-Sheet Peptides that Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S.

J. Am. Chem. Soc. 2011, 133, 3144-3157. pdf html SI

Nanometer-Scale Water-Soluble Macrocycles from Nanometer-Sized Amino Acids

Gothard, C. M.; Nowick, J. S.

J. Org. Chem. 2010, 75, 1822-1830. pdf html SI

In Memoriam: Arthur Stanley Nowick

Nowick, J. S.; Nowick, S. M.

MRS Bulletin 2010, 35, 736-737.

X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

Khakshoor, O.; Lin, A. J.; Korman, T. P.; Sawaya, M. R.; Tsai, S.-C.; Eisenberg, D.; Nowick, J. S.

J. Am. Chem. Soc. 2010, 132, 11622-11628. pdf html SI

 

PDB: 3NI3

Use of Disulfide "Staples" To Stabilize β-Sheet Quaternary Structure

Khakshoor, O.; Nowick, J. S.

Org. Lett. 2009, 11, 3000-3003. pdf html SI

A New Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

Levin, S.; Nowick, J. S.

Org. Lett. 2009, 11, 1003-1006. pdf html SI

Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand

Khasanova, T. V.; Khakshoor, O.; Nowick, J. S.

Org. Lett. 2008, 10, 5293-5296. pdf html SI

Artificial β-Sheets: Chemical Models of β-Sheets

Khakshoor, O.; Nowick, J. S.

Curr. Opin. Chem. Biol. 2008, 12, 722-729. pdf html

Exploring β-Sheet Structure and Interactions with Chemical Model Systems

Nowick, J. S.

Acc. Chem. Res. 2008, 41, 1319-1330. pdf html

 

An Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

Levin, S.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 13043-13048. pdf html SI

Nanometer-Sized Amino Acids for the Synthesis of Nanometer-Scale Water-Soluble Molecular Rods of Precise Length

Gothard, C. M.; Rao, N. A.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 7272-7273. pdf html SI

Macrocyclic β-Sheet Peptides that Mimic Protein Quaternary Structure through Intermolecular β-Sheet Interactions

Khakshoor, O.; Demeler, B.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 5558-5569. pdf html SI

Cyclic Modular β-Sheets

Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 2548-2558. pdf html SI

A New Class of Macrocyclic Receptors from iota-Peptides

Kang, S.-W. Gothard, C. M.; Maitra, S.; Atia-tul-Wahab; Nowick, J. S.

J. Am. Chem. Soc. 2007, 129, 1486-1487. pdf html SI

 

The Absence of Favorable Aromatic Interactions between β-Sheet Peptides

Chung, D. M.; Dou, Y.; Baldi, P.; Nowick, J. S.

J. Am. Chem. Soc. 2005, 127, 9998-9999. pdf html

Enantioselective Molecular Recognition between β-Sheets

Chung, D. M.; Nowick, J. S.

J. Am. Chem. Soc. 2004, 126, 3062-3063. pdf html SI

ICBS: A Database of Protein-Protein Interactions Mediated by β-Sheet Formation

Dou, Y.; Baisnée, P.-F.; Pollastri, G.; Pécout, Y.; Nowick, J.; Baldi, P.

Bioinformatics 2004, 20, 2767-2777. pdf

 

DSA: A New Internal Standard for NMR Studies in Aqueous Solution

Nowick, J. S.; Khakshoor, O.; Hashemzadeh, M.; Brower, J. O.

Org. Lett. 2003, 5, 3511-3513. pdf html SI

 

Dityrosine Crosslinked Aβ Peptides: Fibrillar Beta Structure in Aβ(1-40) is Conducive to Formation of Dityrosine Crosslinks, but a Dityrosine Crosslink in Aβ(8-14) does not Induce Beta Structure

Yoburn, J. C.; Tian, W. Q.; Brower, J. O.; Nowick, J. S.; Glabe, C. G.; Van Vranken, D. L.

Chem. Res. Toxicol. 2003, 16, 531-535. pdf html

 

 

Sequence-Selective Molecular Recognition Between β-Sheets

Nowick, J. S.; Chung, D. M.

Angew. Chem., Int. Ed. 2003, 42, 1765-1768. pdf html

 

A New Turn Structure for the Formation of β-Hairpins in Peptides

Nowick, J. S.; Brower, J. O.

J. Am. Chem. Soc. 2003, 125, 876-877. pdf html

 

A Ribozyme with Michaelase Activity: Synthesis of the Substrate Precursors

Eisenführ, A.; Arora, P. S.; Sengle, G.; Takaoka, L. R.; Nowick J. S.; Famulok, M.

Bioorg. Med. Chem. 2003, 11, 235-249. html

Methylglyoxal Synthetase, enol-Pyruvaldehde, Glutathione, and the Glyoxalase System

Rose, I. A.; Nowick, J. S.

J. Am. Chem. Soc. 2002, 124, 13047-13052. pdf html

 

An Unnatural Amino Acid that Induces β-Sheet Folding and Interaction in Peptides

Nowick, J. S.; Lam, K. S.; Khasanova, T. V.; Kemnitzer, W. E.; Maitra, S.; Mee, H. T.; Liu, R.

J. Am. Chem. Soc. 2002, 124, 4972-4973. pdf html SI

 

Three-Stranded Mixed Artificial β-Sheets

Nowick, J. S.; Smith, E. M.; Ziller, J. W.; Shaka, A. J.

Tetrahedron 2002, 58, 727-739. html

Starving at the Banquet

Nowick, J. S.

Chem Eng. News 2001, 79(13), 178. pdf

A Triply Templated Artificial β-Sheet

Nowick, J. S.; Cary, J. M.; Tsai, J. H.

J. Am. Chem. Soc. 2001, 123, 5176-5180. pdf html SI

Novel RNA Catalysts for the Michael Reaction

Sengle, G.; Eisenführ, A.; Arora, P. S.; Nowick, J. S.; Famulok, M.

Chemistry & Biology 2001, 8, 459-473. html

An Unnatural Amino Acid that Mimics a Tripeptide β-Strand and Forms β-Sheetlike Hydrogen-Bonded Dimers

Nowick, J. S.; Chung, D. M.; Maitra, K.; Maitra, S.; Stigers, K. D.; Sun, Y.

J. Am. Chem. Soc. 2000, 122, 7654-7661. pdf html

Fmoc*: A More Soluble Analogue of the 9-Fluorenylmethoxycarbonyl Protecting Group

Stigers, K. D.; Koutroulis, M. R.; Chung, D. M.; Nowick, J. S.

J. Org. Chem. 2000, 65, 3858-3860. pdf html

"Synthesis, Incorporation Efficiency, and Stability of Disulfide Bridged Functional Groups at RNA 5'-Ends" Sengle, G.; Jenne, A.; Arora, P. S.; Selig, B.; Nowick, J. S.; Jäschke, A.; Famulok, M. Bioorg. Med. Chem. 2000, 8, 1317-1329. pdf html

 

"Synthesis of Amino Acid Ester Isocyanates: Methyl (S)-2-Isocyanato-3-phenylpropanoate" Tsai, J. H.; Takaoka, L. R.; Powell, N. A.; Nowick, J. S.  Org. Synth. 2000, 78, 220-224. pdf html

 

"Designed Molecules that Fold to Mimic Protein Secondary Structures" Stigers, K. D.; Soth, M. J.; Nowick, J. S. Curr. Opin. Chem. Biol. 1999, 3, 714-723. pdf html

 

"A Chemical Model of a Protein β-Sheet Dimer" Nowick, J. S.; Tsai, J. H.; Bui, Q.-C. D.; Maitra, S. J. Am. Chem. Soc. 1999, 121, 8409-8410.

pdf html SI

 

"Folding of an Artificial β-Sheet in Competitive Solvents" Junquera, E.; Nowick, J. S. J. Org. Chem. 1999, 64, 2527-2531. pdf html SI

 

"Two New β-Strand Mimics" Tsai, J. H.; Waldman, A. S.; Nowick, J. S.  Bioorg. Med. Chem. 1999, 7, 29-38. pdf html

 

"A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn"  Soth, M. J.; Nowick, J. S.  J. Org. Chem. 1999, 64, 276-281.

pdf html SI

 

"Chemical Models of Protein β-Sheets" Nowick, J. S.  Acc. Chem. Res. 1999, 32, 287-296. pdf html

 

"An Efficient Synthesis of N,N'-Linked Oligoureas"  Wilson, M. E.; Nowick, J. S. Tetrahedron Lett. 1998, 39, 6613-6616. html

 

"Design and Synthesis of a Transition State Analog for the Diels-Alder Reaction" Arora, P. S; Van, Q. N.; Famulok, M.; Shaka, A. J.; Nowick, J. S.  Bioorg. Med. Chem. 1998, 6, 1421-1428. pdf html

 

"The Alginate Demonstration:  Polymers, Food Science, and Ion Exchange"  Waldman, A. S.; Schechinger, L.; Govindarajoo, G.; Nowick, J. S.; Pignolet, L. H.  J. Chem. Educ. 1998, 75, 1430-1431. pdf html

 

"An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic Template" Smith, E. M.; Holmes, D. L.; Shaka, A. J.; Nowick, J. S.  J. Org. Chem. 1997, 62, 7906-7907. pdf html SI

 

"The Propensities of Amino Acids to Form Parallel β-Sheets" Nowick, J. S.; Insaf, S.  J. Am. Chem. Soc. 1997, 119, 10903-10908. pdf html SI

 

"Model Behaviour"  Nowick, J. S. Chem. Br. 1997, 33(12), 36-39.

 

"Unnatural Oligomers and Oligomer Libraries" Soth, M. J.; Nowick, J. S.  Current Opinion in Chemical Biology 1997, 1, 120-129. html

 

"Solid-Phase Synthesis of Artificial β-Sheets" Holmes, D. L.; Smith, E. M.; Nowick, J. S.  J. Am. Chem. Soc. 1997, 119, 7665-7669.

pdf html SI

 

"An Extended β-Strand Mimic for a Larger Artificial β-Sheet" Nowick, J. S.; Pairish, M.; Lee, I. Q.; Holmes, D. L.; Ziller, J. W. J. Am. Chem. Soc. 1997, 119, 5413-5424. pdf html SI

 

"Artificial β-Sheets"  Nowick, J. S.; Smith, E. M.; Pairish, M. Chem. Soc. Rev. 1996, 25, 401-415. pdf html

 

"Synthesis of Peptide Isocyanates and Isothiocyanates" Nowick, J. S.; Holmes, D. L.; Noronha, G.; Smith, E. M.; Nguyen, T. M.; Huang, S.-L. J. Org. Chem. 1996, 61, 3929-3934. Addition: J. Org. Chem. 1998, 63, 9144. pdf html

 

"An Artificial β-Sheet Comprising a Molecular Scaffold, a β-Strand Mimic, and a Peptide Strand" Nowick, J. S.; Holmes, D. L.; Mackin, G.; Noronha, G.; Shaka, A. J.; Smith, E. M. J. Am. Chem. Soc. 1996, 118, 2764-2765. pdf html

 

"Triurea Derivatives of Diethylenetriamine as Potential Templates for the Formation of Artificial β-Sheets"  Nowick, J. S.; Mahrus, S.; Smith, E. M.; Ziller, J. W.  J. Am. Chem. Soc. 1996, 118, 1066-1072. pdf html SI

 

"A Coordinated Chemistry Outreach Program that Reaches Thousands of High School Students"  Waldman, A. S.; Schechinger, L.; Nowick, J. S.  J. Chem. Educ. 1996, 73, 762-764. pdf

 

"Molecular Scaffolds 3.  An Artificial Parallel β-Sheet" Nowick, J. S.; Smith, E. M.; Noronha, G.  J. Org. Chem. 1995, 60, 7386-7387.

pdf SI

 

"A Novel Hydrogen-Bonded Dimer Containing a Sixteen-Membered Ring"  Nowick, J. S.; Antonovich, V.; Noronha, G.; Ziller, J. W.  J. Org. Chem. 1995, 60, 1888. pdf

 

"Molecular Scaffolds. 2.  Intramolecular Hydrogen Bonding in 1,2-Diaminoethane Diureas"  Nowick, J. S.; Abdi, M.; Bellamo, K. A.; Love, J. A.; Martinez, E. J.; Noronha, G.; Smith, E. M.; Ziller, J. W.  J. Am. Chem. Soc. 1995, 117, 89-99. pdf SI

 

"Molecular Recognition Between Uncharged Molecules in Aqueous Micelles" Nowick, J. S.; Cao, T.; Noronha, G.  J. Am. Chem. Soc. 1994, 116, 3285-3289. pdf

 

"Molecular Recognition in Micelles:  The Roles of Hydrogen Bonding and Hydrophobicity in Adenine-Thymine Base-Pairing in SDS Micelles" Nowick, J. S.; Chen, J. S.; Noronha, G. J. Am. Chem. Soc. 1993, 115, 7636-7644. pdf

 

"An Improved Method for the Synthesis of Enantiomerically Pure Amino Acid Ester Isocyanates" Nowick, J. S.; Powell, N. A.; Nguyen, T. M.; Noronha, G. J. Org. Chem. 1992, 57, 7364-7366. pdf

 

"Molecular Scaffolds I.  Intramolecular Hydrogen Bonding in a Family of Di- and Triureas" Nowick, J. S.; Powell, N. A.; Martinez, E. J.; Smith, E. M.; Noronha, G. J. Org. Chem. 1992, 57, 3763-3765. pdf SI

 

"Molecular Recognition in Aqueous Micellar Solution:  Adenine-Thymine Base-Pairing in SDS Micelles"  Nowick, J. S.; Chen, J. S.  J. Am. Chem. Soc. 1992, 114, 1107-1108. pdf

Publications Prior to UCI

"Self-Replicating Systems" Famulok, M.; Nowick, J. S.; Rebek, J, Jr.  Acta Chem. Scand. 1992, 46, 315. pdf

 

"Kinetic Studies and Modeling of a Self-Replicating System" Nowick, J. S.; Feng,  Q.; Tjivikua, T.; Ballester, P.; J. Rebek, J., Jr.  J. Am. Chem. Soc. 1991, 113, 8831. pdf

 

"A Practical and Efficient Method for the Synthesis of β-Lactones" Danheiser, R. L.; Nowick, J. S.  J. Org. Chem. 1991, 56, 1176. pdf

 

"Convergent Functional Groups. 9. Complexation in New Molecular Clefts" Nowick, J. S.; Ballester, P.; Ebmeyer, F.; Rebek, J. Jr.  J. Am. Chem. Soc. 1990, 112, 8902. pdf

 

"Application of (α-Phosphonoacyl)silane Reagents to the Synthesis of α,β-Unsaturated Acylsilanes" Nowick, J. S.; Danheiser, R. L.,  J. Org. Chem. 1989, 54, 2798. pdf

 

"The M.I.T. Chemistry Outreach Program: Graduate Students Presenting Chemistry to High School Students" Nowick, J. S.; Brisbois, R. G.  J. Chem. Educ. 1989, 66, 668. pdf

 

"Synthesis of Conjugated Optically Active Polymetallocenes" Katz, T. J.; Sudhakar, A.; Yang, B.; Nowick, J. S.  J. Macromol. Sci., Chem. 1989, A26, 309.

 

"Chemistry of Cyclopropylacylsilanes I.  α-Functionalized Acylsilane Reagents for the Cyclopropanation of Electrophilic Alkenes" Nowick, J. S.; Danheiser, R. L.  Tetrahedron 1988, 44, 4113. pdf html

 

"Application of Chiral Lanthanide-Induced Shift Reagents to Optically Active Cations: The Use of Tris[3-(trifluoromethylhydroxymethylene)-(+)-camphorato]europium(III) to Determine the Enantiomeric Purity of Tris(phenanthroline)ruthenium(II) Dichloride" Barton, J. A.; Nowick, J. S. J. Chem. Soc., Chem. Commun. 1984, 1650. pdf