THE NOWICK RESEARCH GROUP
Selected Publications
Investigation of Isobactin Analogs of Teixobactin
Jones, C. R.; Lai, G. H.; Padilla, M. S. T. L.; Nowick, J. S.
ACS Med. Chem. Lett. 2024, 15, 1136-1142. pdf html SI
A turn for the worse: Aβ-hairpins in Alzheimer's disease
Ruttenberg, S. M.; Nowick, J. S.
Bioorg. Med. Chem. 2024, 105, 117715. pdf html
A β-Barrel-Like Tetramer Formed by a β-Hairpin Derived from Aβ
Samdin; T. D.; Jones; C. R.; Guaglianone, G.; Kreutzer, A. G.; Freites, J. A.; Wierzbicki, M.; Nowick, J. S.
Chem. Sci. 2024, 15, 285-297 pdf html SI
PDB: 7RTZ
Generation and Study of Antibodies against Two Triangular Trimers Derived from Aβ
Kreutzer, A. G.†; Malonis, R. J.†; Parrocha, C. M. T.; Tong, K.; Guaglianone, G.; Nguyen, J. T.; Diab, M. N.; Lai, J. R.; Nowick, J. S.
Pept. Sci. 2024, 116 (2), e24333 pdf html SI
†A.G.K. and R.J.M. contributed equally to this work.
PDB: 8T0O
Supramolecular Interactions of Teixobactin Analogues in the Crystal State
Yang, H.; Kreutzer, A. G.; Nowick, J. S.
J. Org. Chem. 2024, 89 (7), 5104-5108 pdf html SI
PDB: 8U78
Probing Differences among Aβ Oligomers with Two Triangular Trimers Derived from Aβ
Kreutzer, A. G.†; Guaglianone, G.†; Yoo, S.; Parrocha, C. M. T.; Ruttenberg, S. M.; Malonis, R. J.; Tong, K.; Lin, Y.; Nguyen, J. T.; Howitz, W. J.; Diab, M. N.; Hamza, I. L.; Lai, J. R. Wysocki, V. H.; Nowick, J. S.
Proc. Natl. Acad. Sci. U. S. A. 2023, 120, e2219216120 pdf html SI
†A.G.K. and G.G. contributed equally to this work.
Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29
Krumberger, M.†; Li, X.†; Kreutzer, A. G.; Peoples, A.J.; Nitti, A. G.; Cunningham, A. M.; Jones, C. R.; Achorn, C.; Ling, L. L.; Hughes, D. E.; Nowick, J. S.
J. Org. Chem. 2023, 88, 2214-2220 pdf html SI
†M.K. and X. L. contributed equally to this work.
Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives
Jones, C. R.; Guaglianone, G.; Lai, G. H.; Nowick, J. S.
Chem. Sci. 2022, 13, 13110-13116 pdf html SI
Teixobactin Kills Bacteria by a Two-pronged Attack on the Cell Envelope
Shukla, R.; Lavore, F.; Maity, S. Derks, M. G. N.; Jones, C. R.; Vermeulen, B. J. A.; Melcrova, A.; Morris, M. A.; Becker, L. M. Wang, X.; Kumar, R.; Medeiros-Silva, J.; van Beekveld, R. A. M.; Bonvin, A. M. J. J.; Lorent, J. H.; Lelli, M.; Nowick, J. S.; MacGillavry, H. D.; Peoples, A. J.; Spoering, A. L.; Ling, L. L.; Hughes, D. E.; Roos, W. H.; Breukink, E.; Lewis, K.; Weingarth, M.
Nature 2022, 608, 390-396 pdf html SI
Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease
Parrocha, C. M. T.; Nowick, J. S.
Pept. Sci. 2022, e24289 pdf html
A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils
Zhang, S.; Yoo, S.; Snyder, D. T.; Katz, B. B.; Henrickson, A.; Demeler, B.; Wysocki, V. H.; Kreutzer, A. G. Nowick, J. S.
Biochemistry 2022, 61, 4, 252-264 pdf html SI
Synthesis and Application of Fluorescent Teixobactin Analogs
Morris, M. A.; Jones, C. R.; Nowick, J. S.
Meth. Enzymol. 2022, 665, 233-258 pdf html
Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM
Hurst, P. J.; Morris, M. A.; Graham, A. A.; Nowick, J. S.; Patterson, J. P.
ACS Omega 2021, 6, 27412-27417 pdf html SI
An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides
Li, X.; Sabol, A. L.; Wierzbicki, M.; Salveson, P. J.; Nowick, J. S.
Angew. Chem. Int. Ed. 2021, 60, 22776-22782 pdf html SI
Exploring Amyloid Oligomers with Peptide Model Systems
Samdin, T. D.; Kreutzer, A. G.; Nowick, J. S.
Curr. Opin. Chem. Biol. 2021, 64, 106-115 pdf html
Synthesis and Study of Macrocyclic β-Hairpin Peptides for Investigating Amyloid Oligomers
Guaglianone, G.; Kreutzer, A. G.; Nowick, J. S.
Meth. Enzymol. 2021, 656, 123-168. pdf html
A Cyclic Peptide Inhibitor of the SARS-CoV-2 Main Protease
Kreutzer, A. G.; Krumberger, M.; Diessner, E. M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Butts, C. T.; Nowick, J. S.
Eur. J. Med. Chem. 2021, 221, 113530 pdf html SI
PREPRINT: Kreutzer, A. G.; Krumberger, M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Nowick, J. S.
bioRxiv doi: https://doi.org/10.1101/2020.08.03.234872
An aza-Diels–Alder Route to Quinoline-Based Unnatural Amino Acids and Polypeptide Surrogates
Umerani, M. J.; Yang, H.; Pratakshya, P.; Nowick, J. S.; Gorodetsky, A. A.
RSC Adv. 2021, 11, 14132-14139 pdf html SI
Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42
Zhang, S.; Guaglianone, G.; Morris, M. A.; Yoo, S.; Howitz, W. J.; Xing, L.; Zheng, J.; Jusuf, H.; Huizar, G.; Lin, J.; Kreutzer, A. G.; Nowick, J. S.
Biochemistry 2021, 60, 1191-1200 pdf html SI Correction: Biochemistry 2021 pdf html
Zhang, S.; Krumberger, M.†; Morris, M. A.†; Parrocha, C. M. T.; Kreutzer, A. G.; Nowick, J. S.
Eur. J. Med. Chem. 2021, 218, 11390 pdf html SI
†M.K. and M. A. M. contributed equally to this work.
PREPRINT: Zhang, S.; Krumberger, M.; Morris, M. A.; Parrocha, C. M. T.; Griffin, J. H.;
Kreutzer, A. G.; Nowick J. S. ChemRxiv, doi: https://doi.org/10.26434/chemrxiv.12791954
Interpreting Cubes in the X-Ray Crystallographic Structure of a Peptide Derived from Medin19–36
Howitz, W. J.; Wierzbicki, M.; Cabanela, R. W.; Saliba, C.; Motovalli, A.; Tran, N.; Nowick, J. S.
J. Am. Chem. Soc. 2020, 142, 15870-15875 pdf html SI
PDB: 7JRH
Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ
Samdin, T. D.; Wierzbicki, M.; Kreutzer, A. G.; Howitz, W. J.; Valenzuela, M.; Smith, A.; Sahrai, V. S.; Truex, N. L.; Klun, M.; Nowick, J. S.
J. Am. Chem. Soc. 2020, 142, 11593-11601. pdf html SI
PDB: 6VU4
A Fluorescent Teixobactin Analogue
Morris, M. A.; Malek, M.; Hashemian, M. H.; Nguyen, B. T.; Manuse S.; Lewis, K.; Nowick, J. S.
ACS Chem. Biol. 2020, 15, 1222-1231. pdf html SI
This article is part of the Chemical Microbiology special issue.
Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin
Yang, H; Pishenko, A. V.; Li, X.; Nowick, J. S.
J. Org. Chem. 2020, 85, 1331-1339. pdf html SI
PDB: 6PSL
Sahoo, B. R.; Bekier, M. E., II; Liu, Z.; Kocman, V.; Stoddard, A. K.; Anantharamaiah, G. M.; Nowick, J.; Fierke, C.; Wang, Y.; Ramamoorthy, A.
J. Mol. Biol. 2020, 432, 1020-1034. html
Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation
Lu, J.; Cao, Q.; Wang, C.; Zheng, J.: Luo, F.; Xie, J.; Li, Y.; Ma, X.; He, L.; Eisenberg, D.; Nowick, J.; Jiang, L.; Li, D.
Front. Mol. Neurosci. 2019, 12, 54. html
X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly
Yang, H; Wierzbicki, M.; Du Bois, D. R.; Nowick, J. S.
J. Am. Chem. Soc. 2018, 140, 14028-14032. pdf html SI
PDB: 6E00
Repurposing triphenylmethane dyes to bind to trimers derived from Aβ
Salveson, P. J.; Haerianardakani, S.; Thuy-Boun, A.; Yoo, S.; Kreutzer, A. G.; Nowick, J. S.
J. Am. Chem. Soc. 2018, 140, 11745-11754. Correction: J. Am. Chem. Soc. 2018, 140, 15546-15546. pdf html SI
An efficient method for the expression and purification of Aβ(M1–42)
Yoo, S.†; Zhang, S.†; Kreutzer, A. G.; Nowick, J. S.
Biochemistry 2018, 57, 3861-3866. pdf html SI
†S. Y. and S. Z. contributed equally to this work.
Effects of Charge and Hydrophobicity on the Oligomerization of Peptides Derived from IAPP
Wang, Y.; Truex, N. L.; Vo, N. D. P.; Nowick, J. S.
Bioorganic Med. Chem. 2018, 26, 1151-1156. pdf html SI
Alanine Scan Reveals Modifiable Residues in Teixobactin
Chen, K.H.; Le, S. P.; Han, X.; Frias, J. M.; Nowick, J. S.
Chem. Commun. 2017, 53, 11357-11359. pdf html SI
Transmembrane Proteins: Amyloids Hidden in Plain Sight?
Truex, N. L.; Nowick, J. S.
Biochemistry 2017, 56, 4735-4736. pdf html
A Tetramer Derived from Islet Amyloid Polypeptide
Wang, Y.; Kreutzer, A. G.; Truex, N.L.; Nowick, J. S.
J. Org. Chem. 2017, 82, 7905-7912. pdf html SI
PDB: 5UHR
Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid
Truex, N. L.; Wang, Y.; Nowick, J. S.
J. Am. Chem. Soc. 2016, 138, 13882-13890. pdf html SI
Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid
Truex, N. L.; Nowick, J. S.
J. Am. Chem. Soc. 2016, 138, 13891-13900. pdf html SI
Square channels formed by a peptide derived from transthyretin
Yoo, S.; Kreutzer A. G.; Truex, N. L.; Nowick, J. S.
Chem. Sci. 2016, 7, 6946-6951. pdf html SI
PDB: 5HPP
Elucidation of the Teixobactin Pharmacophore
Yang, H.; Chen, K. H.; Nowick, J. S.
X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin
Spencer, R. K.; Kreutzer, A. G.; Salveson, P. J.; Li, H.; Nowick, J. S.
J. Am. Chem. Soc. 2015, 137, 6304-6311. pdf html SI
A Newcomer’s Guide to Peptide Crystallography
Spencer, R. K.; Nowick, J. S.
Israel J. Chem. 2015, 55, 698-710. pdf html
A Fibril-like Assembly of Oligomers of a Peptide Derived from β-Amyloid
Pham, J. D.; Spencer, R. K.; Chen, K. H.; Nowick, J. S.
J. Am. Chem. Soc. 2014, 136, 12682-12690. pdf html SI
PDB: 4Q8D
Polymorphism of Oligomers of a Peptide from β-Amyloid
Pham, J. D.; Demeler, B.; Nowick, J. S.
Mechanism of IAPP Amyloid Fibril Formation Involves an Intermediate with a Transient β-Sheet
Buchanan, L. E.; Dunkelberger, E. B.; Tran, H. Q.; Cheng, P.-N.; Chiu, C.-C.; Cao, P.; Raleigh, D. P.; de Pablo, J. J.; Nowick, J. S.; Zanni, M. T.
Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19285-19290. pdf html SI
Structures of Oligomers of a Peptide from β-Amyloid
Pham, J. D.; Chim, N.; Goulding, C. W.; Nowick, J. S.
J. Am. Chem. Soc. 2013, 135, 12460-12467. pdf html SI
PDB: 4IVH
Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences
Spencer, R.; Chen, K. H.; Manuel, G.; Nowick, J. S.
A Hydrophobic Surface is Essential to Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide
Zheng, J.; Baghkhanian, A. M.; Nowick, J. S.
The Supramolecular Chemistry of β-Sheets
Cheng, P.-N.; Pham, J. D.; Nowick, J. S.
J. Am. Chem. Soc. 2013, 135, 5477–5492. pdf html
Amyloid β-Sheet Mimics that Antagonize Protein Aggregation and Reduce Amyloid Toxicity
Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg, D.; Nowick, J. S.
Nat. Chem. 2012, 4, 927-933. pdf html SI
PDB: 3T4G
Out-of-Register β-Sheets Suggest a Pathway to Toxic Amyloid Aggregates
Liu, C.; Zhao, M.; Jiang, L.; Cheng,P.-N.; Park, J.; Sawaya M.R.; Pensalfini, A.; Gou, D.; Berk A. J.; Glabe C. G.; Nowick, J. S.; Eisenberg. D.
Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 20913-20918. pdf html SI
Litter decay rates are determined by lignin chemistry
Talbot, J. M.; Yelle, D. J.; Nowick, J. S.; Treseder, K. K.
Biogeochemistry 2012, 108, 279-295. html
Giant Macrolactams Based on β-Sheet Peptides
Cheng,P.-N.; Nowick, J. S.
Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D.
J. Am. Chem. Soc. 2011, 133, 6736-6744. pdf html SI
Macrocyclic β-Sheet Peptides that Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide
Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S.
Nanometer-Scale Water-Soluble Macrocycles from Nanometer-Sized Amino Acids
Gothard, C. M.; Nowick, J. S.
X-ray Crystallographic Structure of an Artificial β-Sheet Dimer
Khakshoor, O.; Lin, A. J.; Korman, T. P.; Sawaya, M. R.; Tsai, S.-C.; Eisenberg, D.; Nowick, J. S.
J. Am. Chem. Soc. 2010, 132, 11622-11628. pdf html SI
PDB: 3NI3
Meng, X.; Nguyen, W. H.; Nowick, J. S.; Shaka, A. J.
J. Mag. Res. 2010, 203, 73-80. html
Use of Disulfide "Staples" To Stabilize β-Sheet Quaternary Structure
Khakshoor, O.; Nowick, J. S.
A New Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions
Levin, S.; Nowick, J. S.
Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand
Khasanova, T. V.; Khakshoor, O.; Nowick, J. S.
Artificial β-Sheets: Chemical Models of β-Sheets
Khakshoor, O.; Nowick, J. S.
Exploring β-Sheet Structure and Interactions with Chemical Model Systems
Nowick, J. S.
Acc. Chem. Res. 2008, 41, 1319-1330. pdf html
An Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions
Levin, S.; Nowick, J. S.
Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S.
A New Class of Macrocyclic Receptors from iota-Peptides
Kang, S.-W. Gothard, C. M.; Maitra, S.; Atia-tul-Wahab; Nowick, J. S.
J. Am. Chem. Soc. 2007, 129, 1486-1487. pdf html SI
What I Have Learned by Using Chemical Model Systems to Study Biomolecular Structure and Interactions
Nowick, J. S.
The Absence of Favorable Aromatic Interactions between β-Sheet Peptides
Chung, D. M.; Dou, Y.; Baldi, P.; Nowick, J. S.
Enantioselective Molecular Recognition between β-Sheets
Chung, D. M.; Nowick, J. S.
ICBS: A Database of Protein-Protein Interactions Mediated by β-Sheet Formation
Dou, Y.; Baisnée, P.-F.; Pollastri, G.; Pécout, Y.; Nowick, J.; Baldi, P.
Bioinformatics 2004, 20, 2767-2777. pdf
DSA: A New Internal Standard for NMR Studies in Aqueous Solution
Nowick, J. S.; Khakshoor, O.; Hashemzadeh, M.; Brower, J. O.
Org. Lett. 2003, 5, 3511-3513. pdf html SI
Yoburn, J. C.; Tian, W. Q.; Brower, J. O.; Nowick, J. S.; Glabe, C. G.; Van Vranken, D. L.
Chem. Res. Toxicol. 2003, 16, 531-535. pdf html
Sequence-Selective Molecular Recognition Between β-Sheets
Nowick, J. S.; Chung, D. M.
Angew. Chem., Int. Ed. 2003, 42, 1765-1768. pdf html
A New Turn Structure for the Formation of β-Hairpins in Peptides
Nowick, J. S.; Brower, J. O.
J. Am. Chem. Soc. 2003, 125, 876-877. pdf html
A Ribozyme with Michaelase Activity: Synthesis of the Substrate Precursors
Eisenführ, A.; Arora, P. S.; Sengle, G.; Takaoka, L. R.; Nowick J. S.; Famulok, M.
Methylglyoxal Synthetase, enol-Pyruvaldehde, Glutathione, and the Glyoxalase System
Rose, I. A.; Nowick, J. S.
J. Am. Chem. Soc. 2002, 124, 13047-13052. pdf html
An Unnatural Amino Acid that Induces β-Sheet Folding and Interaction in Peptides
Nowick, J. S.; Lam, K. S.; Khasanova, T. V.; Kemnitzer, W. E.; Maitra, S.; Mee, H. T.; Liu, R.
J. Am. Chem. Soc. 2002, 124, 4972-4973. pdf html SI
Three-Stranded Mixed Artificial β-Sheets
Nowick, J. S.; Smith, E. M.; Ziller, J. W.; Shaka, A. J.
Tetrahedron 2002, 58, 727-739. html
A Triply Templated Artificial β-Sheet
Nowick, J. S.; Cary, J. M.; Tsai, J. H.
Novel RNA Catalysts for the Michael Reaction
Sengle, G.; Eisenführ, A.; Arora, P. S.; Nowick, J. S.; Famulok, M.
Chemistry & Biology 2001, 8, 459-473. html
Fmoc*: A More Soluble Analogue of the 9-Fluorenylmethoxycarbonyl Protecting Group
Stigers, K. D.; Koutroulis, M. R.; Chung, D. M.; Nowick, J. S.
"Synthesis, Incorporation Efficiency, and Stability of Disulfide Bridged Functional Groups at RNA 5'-Ends" Sengle, G.; Jenne, A.; Arora, P. S.; Selig, B.; Nowick, J. S.; Jäschke, A.; Famulok, M. Bioorg. Med. Chem. 2000, 8, 1317-1329. pdf html
"Synthesis of Amino Acid Ester Isocyanates: Methyl (S)-2-Isocyanato-3-phenylpropanoate" Tsai, J. H.; Takaoka, L. R.; Powell, N. A.; Nowick, J. S. Org. Synth. 2000, 78, 220-224. pdf html
"Designed Molecules that Fold to Mimic Protein Secondary Structures" Stigers, K. D.; Soth, M. J.; Nowick, J. S. Curr. Opin. Chem. Biol. 1999, 3, 714-723. pdf html
"A Chemical Model of a Protein β-Sheet Dimer" Nowick, J. S.; Tsai, J. H.; Bui, Q.-C. D.; Maitra, S. J. Am. Chem. Soc. 1999, 121, 8409-8410.
"Folding of an Artificial β-Sheet in Competitive Solvents" Junquera, E.; Nowick, J. S. J. Org. Chem. 1999, 64, 2527-2531. pdf html SI
"Two New β-Strand Mimics" Tsai, J. H.; Waldman, A. S.; Nowick, J. S. Bioorg. Med. Chem. 1999, 7, 29-38. pdf html
"A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn" Soth, M. J.; Nowick, J. S. J. Org. Chem. 1999, 64, 276-281.
"Chemical Models of Protein β-Sheets" Nowick, J. S. Acc. Chem. Res. 1999, 32, 287-296. pdf html
"An Efficient Synthesis of N,N'-Linked Oligoureas" Wilson, M. E.; Nowick, J. S. Tetrahedron Lett. 1998, 39, 6613-6616. html
"Design and Synthesis of a Transition State Analog for the Diels-Alder Reaction" Arora, P. S; Van, Q. N.; Famulok, M.; Shaka, A. J.; Nowick, J. S. Bioorg. Med. Chem. 1998, 6, 1421-1428. pdf html
"The Alginate Demonstration: Polymers, Food Science, and Ion Exchange" Waldman, A. S.; Schechinger, L.; Govindarajoo, G.; Nowick, J. S.; Pignolet, L. H. J. Chem. Educ. 1998, 75, 1430-1431. pdf html
"An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic Template" Smith, E. M.; Holmes, D. L.; Shaka, A. J.; Nowick, J. S. J. Org. Chem. 1997, 62, 7906-7907. pdf html SI
"The Propensities of Amino Acids to Form Parallel β-Sheets" Nowick, J. S.; Insaf, S. J. Am. Chem. Soc. 1997, 119, 10903-10908. pdf html SI
"Model Behaviour" Nowick, J. S. Chem. Br. 1997, 33(12), 36-39.
"Unnatural Oligomers and Oligomer Libraries" Soth, M. J.; Nowick, J. S. Current Opinion in Chemical Biology 1997, 1, 120-129. html
"Solid-Phase Synthesis of Artificial β-Sheets" Holmes, D. L.; Smith, E. M.; Nowick, J. S. J. Am. Chem. Soc. 1997, 119, 7665-7669.
"An Extended β-Strand Mimic for a Larger Artificial β-Sheet" Nowick, J. S.; Pairish, M.; Lee, I. Q.; Holmes, D. L.; Ziller, J. W. J. Am. Chem. Soc. 1997, 119, 5413-5424. pdf html SI
"Artificial β-Sheets" Nowick, J. S.; Smith, E. M.; Pairish, M. Chem. Soc. Rev. 1996, 25, 401-415. pdf html
"Synthesis of Peptide Isocyanates and Isothiocyanates" Nowick, J. S.; Holmes, D. L.; Noronha, G.; Smith, E. M.; Nguyen, T. M.; Huang, S.-L. J. Org. Chem. 1996, 61, 3929-3934. Addition: J. Org. Chem. 1998, 63, 9144. pdf html
"An Artificial β-Sheet Comprising a Molecular Scaffold, a β-Strand Mimic, and a Peptide Strand" Nowick, J. S.; Holmes, D. L.; Mackin, G.; Noronha, G.; Shaka, A. J.; Smith, E. M. J. Am. Chem. Soc. 1996, 118, 2764-2765. pdf html
"Triurea Derivatives of Diethylenetriamine as Potential Templates for the Formation of Artificial β-Sheets" Nowick, J. S.; Mahrus, S.; Smith, E. M.; Ziller, J. W. J. Am. Chem. Soc. 1996, 118, 1066-1072. pdf html SI
"A Coordinated Chemistry Outreach Program that Reaches Thousands of High School Students" Waldman, A. S.; Schechinger, L.; Nowick, J. S. J. Chem. Educ. 1996, 73, 762-764. pdf
"Molecular Scaffolds 3. An Artificial Parallel β-Sheet" Nowick, J. S.; Smith, E. M.; Noronha, G. J. Org. Chem. 1995, 60, 7386-7387.
"A Novel Hydrogen-Bonded Dimer Containing a Sixteen-Membered Ring" Nowick, J. S.; Antonovich, V.; Noronha, G.; Ziller, J. W. J. Org. Chem. 1995, 60, 1888. pdf
"Molecular Scaffolds. 2. Intramolecular Hydrogen Bonding in 1,2-Diaminoethane Diureas" Nowick, J. S.; Abdi, M.; Bellamo, K. A.; Love, J. A.; Martinez, E. J.; Noronha, G.; Smith, E. M.; Ziller, J. W. J. Am. Chem. Soc. 1995, 117, 89-99. pdf SI
"Molecular Recognition Between Uncharged Molecules in Aqueous Micelles" Nowick, J. S.; Cao, T.; Noronha, G. J. Am. Chem. Soc. 1994, 116, 3285-3289. pdf
"Molecular Recognition in Micelles: The Roles of Hydrogen Bonding and Hydrophobicity in Adenine-Thymine Base-Pairing in SDS Micelles" Nowick, J. S.; Chen, J. S.; Noronha, G. J. Am. Chem. Soc. 1993, 115, 7636-7644. pdf
"An Improved Method for the Synthesis of Enantiomerically Pure Amino Acid Ester Isocyanates" Nowick, J. S.; Powell, N. A.; Nguyen, T. M.; Noronha, G. J. Org. Chem. 1992, 57, 7364-7366. pdf
"Molecular Scaffolds I. Intramolecular Hydrogen Bonding in a Family of Di- and Triureas" Nowick, J. S.; Powell, N. A.; Martinez, E. J.; Smith, E. M.; Noronha, G. J. Org. Chem. 1992, 57, 3763-3765. pdf SI
"Molecular Recognition in Aqueous Micellar Solution: Adenine-Thymine Base-Pairing in SDS Micelles" Nowick, J. S.; Chen, J. S. J. Am. Chem. Soc. 1992, 114, 1107-1108. pdf
Publications Prior to UCI
"Self-Replicating Systems" Famulok, M.; Nowick, J. S.; Rebek, J, Jr. Acta Chem. Scand. 1992, 46, 315. pdf
"Kinetic Studies and Modeling of a Self-Replicating System" Nowick, J. S.; Feng, Q.; Tjivikua, T.; Ballester, P.; J. Rebek, J., Jr. J. Am. Chem. Soc. 1991, 113, 8831. pdf
"A Practical and Efficient Method for the Synthesis of β-Lactones" Danheiser, R. L.; Nowick, J. S. J. Org. Chem. 1991, 56, 1176. pdf
"Convergent Functional Groups. 9. Complexation in New Molecular Clefts" Nowick, J. S.; Ballester, P.; Ebmeyer, F.; Rebek, J. Jr. J. Am. Chem. Soc. 1990, 112, 8902. pdf
"Application of (α-Phosphonoacyl)silane Reagents to the Synthesis of α,β-Unsaturated Acylsilanes" Nowick, J. S.; Danheiser, R. L., J. Org. Chem. 1989, 54, 2798. pdf
"The M.I.T. Chemistry Outreach Program: Graduate Students Presenting Chemistry to High School Students" Nowick, J. S.; Brisbois, R. G. J. Chem. Educ. 1989, 66, 668. pdf
"Synthesis of Conjugated Optically Active Polymetallocenes" Katz, T. J.; Sudhakar, A.; Yang, B.; Nowick, J. S. J. Macromol. Sci., Chem. 1989, A26, 309.
"Chemistry of Cyclopropylacylsilanes I. α-Functionalized Acylsilane Reagents for the Cyclopropanation of Electrophilic Alkenes" Nowick, J. S.; Danheiser, R. L. Tetrahedron 1988, 44, 4113. pdf html
"Application of Chiral Lanthanide-Induced Shift Reagents to Optically Active Cations: The Use of Tris[3-(trifluoromethylhydroxymethylene)-(+)-camphorato]europium(III) to Determine the Enantiomeric Purity of Tris(phenanthroline)ruthenium(II) Dichloride" Barton, J. A.; Nowick, J. S. J. Chem. Soc., Chem. Commun. 1984, 1650. pdf