Nowick Research Group University of California, Irvine

154 papers · 1984–2025

Publications

Every paper from the group. Search by title, author, journal or PDB code.

2025

  1. A β-hairpin Peptide Derived from Aβ Forms Different Oligomers in the Crystal State and in Aqueous Solution

    Zhu, J.; Kreutzer, A. G.; Liu, Z.; Li, X.; Richter, S. M.; Vojislava, P.; Nowick, J. S.

    Org. Biomol. Chem. 2025, 23, 3881-3893.

    DOIFree PDFPDFSupporting infoPDB 9EEC

  2. Antibodies Raised Against a Structurally Defined Aβ Oligomer Mimic Protects Human iPSC Neurons from Aβ Toxicity at Substoichiometric Concentrations

    Ruttenberg, S. M.; Dhaoui, R.; Kreutzer, A. G.; Nowick, J. S.

    PLoS One 2025, 23 (9), e0331024.

    DOIFree PDFPDF

  3. Cyclic β-sheet peptides

    Carrera, J. I. P.; Nowick, J. S.

    Meth. Enzymol. 2025, 723, 21-45.

    DOI

  4. Potent Analogues of Clovibactin from Commerically Available Amino Acid Building Blocks

    Brunicardi, J. E. H.; Small, J. S.; Padilla, M. S. T. L.; Carrera, J. I. P.; Nowick, J. S.

    J. Org. Chem. 2025, 90, 5, 2132-2136.

    DOIFree PDFPDFSupporting info

  5. Using solution-phase NMR spectroscopy to study the folding and supramolecular assembly of conformationally constrained β-sheet peptides

    Zhu, J.; Nowick, J. S.

    Meth. Enzymol. 2025, 723, 477-509.

    Preprint: Zhu, J.; Nowick, J. S. ChemRxiv, doi: 10.26434/chemrxiv-2025-d9pxp

    DOI

  6. Vancomycin–Teixobactin Conjugates

    Padilla, M. S. T. L.; Nowick, J. S.

    J. Am. Chem. Soc. 2025, 147, 8, 6343-6348.

    DOIFree PDFPDFSupporting info

  7. α-Methylation Enables the X-ray Crystallographic Observation of Oligomeric Assemblies Formed by a β-Hairpin Peptide

    Samdin, T. D.; Kreutzer, A. G.; Sahrai, V.; Wierzbicki, M.; Nowick, J. S.

    J. Org. Chem. 2025, 90, 1, 394-400.

    DOIFree PDFPDFSupporting infoPDB 9BI3

2024

  1. A turn for the worse: Aβ-hairpins in Alzheimer's disease

    Ruttenberg, S. M.; Nowick, J. S.

    Bioorg. Med. Chem. 2024, 105, 117715.

    DOIFree PDFPDF

  2. A β-Barrel-Like Tetramer Formed by a β-Hairpin Derived from Aβ

    Samdin; T. D.; Jones; C. R.; Guaglianone, G.; Kreutzer, A. G.; Freites, J. A.; Wierzbicki, M.; Nowick, J. S.

    Chem. Sci. 2024, 15, 285-297.

    DOIFree PDFPDFSupporting infoPDB 7RTZ

  3. Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue

    Kreutzer, A. G.; Parrocha, C. M. T.; Haerianardakani, S.; Guaglianone, G.; Nguyen, J. T.; Diab, M. N.; Yong, W.; Perez, M.; Head, E.; Nowick, J. S.

    ACS Central Science, 2024, 10, 104-121.

    DOIFree PDFPDFSupporting infoPDB 7U4P

  4. Generation and Study of Antibodies against Two Triangular Trimers Derived from Aβ

    Kreutzer, A. G.†; Malonis, R. J.†; Parrocha, C. M. T.; Tong, K.; Guaglianone, G.; Nguyen, J. T.; Diab, M. N.; Lai, J. R.; Nowick, J. S.

    Pept. Sci. 2024, 116 (2), e24333.

    contributed equally to this work.

    DOIFree PDFPDFSupporting infoPDB 8T0O

  5. Investigation of Isobactin Analogs of Teixobactin

    Jones, C. R.; Lai, G. H.; Padilla, M. S. T. L.; Nowick, J. S.

    ACS Med. Chem. Lett. 2024, 15, 1136-1142.

    DOIFree PDFPDFSupporting info

  6. Structure-Activity Relationship Studies of the Peptide Antibiotic Clovibactin

    Brunicardi, J. E. H.; Griffin, J. H.; Ferracane, M. J.; Kreutzer, A. G.; Small, J.; Mendoza, A.-T.; Ziller, J. W.; Nowick, J. S.

    J. Org. Chem. 2024, 89, 17, 12479-12484.

    DOIFree PDFPDFSupporting infoPDB 9BIC

  7. Supramolecular Interactions of Teixobactin Analogues in the Crystal State

    Yang, H.; Kreutzer, A. G.; Nowick, J. S.

    J. Org. Chem. 2024, 89 (7), 5104-5108.

    DOIFree PDFPDFSupporting infoPDB 8U78

  8. Teixobactin "Swapmers" With L Tail Stereochemistry Retain Antibiotic Activity

    Griffin, J. H.; Mendoza, A.-T.; Nowick, J. S.

    J. Org. Chem. 2024, 89, 20, 15325-15330.

    DOIFree PDFPDFSupporting info

  9. β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides

    Ruttenberg, S. M.; Kreutzer, A. G.; Truex, N. L.; Nowick, J. S.

    Biochemistry 2024, 63, 212-218.

    DOIFree PDFPDFSupporting infoPDB 8GJCPDB 8GJD

2023

  1. Probing Differences among Aβ Oligomers with Two Triangular Trimers Derived from Aβ

    Kreutzer, A. G.†; Guaglianone, G.†; Yoo, S.; Parrocha, C. M. T.; Ruttenberg, S. M.; Malonis, R. J.; Tong, K.; Lin, Y.; Nguyen, J. T.; Howitz, W. J.; Diab, M. N.; Hamza, I. L.; Lai, J. R. Wysocki, V. H.; Nowick, J. S.

    Proc. Natl. Acad. Sci. U. S. A. 2023, 120, e2219216120.

    contributed equally to this work.

    DOIFree PDFPDFSupporting infoPDB 8EC9PDB 8ECA

  2. Synthesis and Stereochemical Determination of the Peptide Antibiotic Novo29

    Krumberger, M.†; Li, X.†; Kreutzer, A. G.; Peoples, A.J.; Nitti, A. G.; Cunningham, A. M.; Jones, C. R.; Achorn, C.; Ling, L. L.; Hughes, D. E.; Nowick, J. S.

    J. Org. Chem. 2023, 88, 2214-2220.

    contributed equally to this work.

    DOIFree PDFPDFSupporting info

2022

  1. A Disulfide-Stabilized Aβ that Forms Dimers but Does Not Form Fibrils

    Zhang, S.; Yoo, S.; Snyder, D. T.; Katz, B. B.; Henrickson, A.; Demeler, B.; Wysocki, V. H.; Kreutzer, A. G. Nowick, J. S.

    Biochemistry 2022, 61, 4, 252-264.

    DOIFree PDFPDFSupporting info

  2. Current Peptide Vaccine and Immunotherapy Approaches Against Alzheimer's Disease

    Parrocha, C. M. T.; Nowick, J. S.

    Pept. Sci. 2022, e24289.

    DOIFree PDFPDFSupporting info

  3. Effects of Familial Alzheimer’s Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ16–36

    McKnelly, K. J.; Kreutzer, A. G.; Howitz, W. J.; Haduong, K.; Yoo, S.; Hart, S.; Nowick, J. S.

    Biochemistry 2022, 61, 446-454.

    DOIFree PDFPDFSupporting info

  4. Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies

    Guaglianone, G.; Torrado, B.; Lin, Y.; Watkins, M. C.; Wysocki, V. H.; Gratton, E.; Nowick, J. S.

    ACS Chem. Neurosci. 2022, 13, 2473-2482.

    DOIFree PDFPDFSupporting info

  5. Enantiomeric β-Sheet Peptides from Aβ Form Homochiral Pleated β-Sheets Rather Than Heterochiral Rippled β-Sheets

    Li, X.; Rios, S. E.; Nowick, J. S.

    Chem. Sci. 2022, 13, 7739-7746 Cover Art.

    DOIFree PDFPDFSupporting info

  6. Isobactins: O-acyl isopeptide prodrugs of teixobactin and teixobactin derivatives

    Jones, C. R.; Guaglianone, G.; Lai, G. H.; Nowick, J. S.

    Chem. Sci. 2022, 13, 13110-13116.

    DOIFree PDFPDFSupporting info

  7. Macrocyclic Peptides Derived from Familial Alzheimer’s Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity

    Howitz, W. J.; Guaglianone, G.; McKnelly, K. J.; Haduong, K.; Ashby, S. N.; Laayouni, M.; Nowick, J. S.

    ACS Chem. Neurosci. 2022, 13, 714-720.

    DOIFree PDFPDFSupporting info

  8. Synthesis and Application of Fluorescent Teixobactin Analogs

    Morris, M. A.; Jones, C. R.; Nowick, J. S.

    Meth. Enzymol. 2022, 665, 233-258.

    DOIFree PDF

  9. Teixobactin Kills Bacteria by a Two-pronged Attack on the Cell Envelope

    Shukla, R.; Lavore, F.; Maity, S. Derks, M. G. N.; Jones, C. R.; Vermeulen, B. J. A.; Melcrova, A.; Morris, M. A.; Becker, L. M. Wang, X.; Kumar, R.; Medeiros-Silva, J.; van Beekveld, R. A. M.; Bonvin, A. M. J. J.; Lorent, J. H.; Lelli, M.; Nowick, J. S.; MacGillavry, H. D.; Peoples, A. J.; Spoering, A. L.; Ling, L. L.; Hughes, D. E.; Roos, W. H.; Breukink, E.; Lewis, K.; Weingarth, M.

    Nature 2022, 608, 390-396.

    DOIFree PDFPDFSupporting info

  10. Visualizing the Mode of Action and Supramolecular Assembly of Teixobactin Analogues in Bacillus subtilis

    Morris, M, A,; Vallmitjana, A.; Grein, F.; Schneider, T.; Arts, M.; Jones, C. R.; Nguyen, B. T.; Hashemian, M. H.; Malek, M.; Gratton, E.; Nowick, J. S.

    Chem. Sci. 2022, 13, 7747-7754. Cover Art.

    DOIFree PDFPDFSupporting info

2021

  1. A Cyclic Peptide Inhibitor of the SARS-CoV-2 Main Protease

    Kreutzer, A. G.; Krumberger, M.; Diessner, E. M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Butts, C. T.; Nowick, J. S.

    Eur. J. Med. Chem. 2021, 221, 113530.

    Preprint: Kreutzer, A. G.; Krumberger, M.; Parrocha, C. M. T.; Morris, M. A.; Guaglianone, G.; Nowick, J. S. bioRxiv doi: https://doi.org/10.1101/2020.08.03.234872

    DOIFree PDFSupporting info

  2. An Improved Turn Structure for Inducing β-Hairpin Formation in Peptides

    Li, X.; Sabol, A. L.; Wierzbicki, M.; Salveson, P. J.; Nowick, J. S.

    Angew. Chem. Int. Ed. 2021, 60, 22776-22782.

    DOIFree PDFPDFSupporting info

  3. An aza-Diels–Alder Route to Quinoline-Based Unnatural Amino Acids and Polypeptide Surrogates

    Umerani, M. J.; Yang, H.; Pratakshya, P.; Nowick, J. S.; Gorodetsky, A. A.

    RSC Adv. 2021, 11, 14132-14139.

    DOIPDF

  4. Exploring Amyloid Oligomers with Peptide Model Systems

    Samdin, T. D.; Kreutzer, A. G.; Nowick, J. S.

    Curr. Opin. Chem. Biol. 2021, 64, 106-115.

    DOIFree PDF

  5. Expression of N-Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42

    Zhang, S.; Guaglianone, G.; Morris, M. A.; Yoo, S.; Howitz, W. J.; Xing, L.; Zheng, J.; Jusuf, H.; Huizar, G.; Lin, J.; Kreutzer, A. G.; Nowick, J. S.

    Biochemistry 2021, 60, 1191-1200 Correction: Biochemistry 2021.

    DOIFree PDFPDFSupporting info

  6. Structure-Based Drug Design of an Inhibitor of the SARS-CoV-2 (COVID-19) Main Protease Using Free Software: A Tutorial for Students and Scientists

    Zhang, S.; Krumberger, M.†; Morris, M. A.†; Parrocha, C. M. T.; Kreutzer, A. G.; Nowick, J. S.

    Eur. J. Med. Chem. 2021, 218, 11390.

    contributed equally to this work.

    Preprint: Zhang, S.; Krumberger, M.; Morris, M. A.; Parrocha, C. M. T.; Griffin, J. H.; Kreutzer, A. G.; Nowick J. S. ChemRxiv, doi: https://doi.org/10.26434/chemrxiv.12791954

    DOISupporting info

  7. Synthesis and Study of Macrocyclic β-Hairpin Peptides for Investigating Amyloid Oligomers

    Guaglianone, G.; Kreutzer, A. G.; Nowick, J. S.

    Meth. Enzymol. 2021, 656, 123-168.

    DOIFree PDF

  8. Visualizing Teixobactin Supramolecular Assemblies and Cell Wall Damage in B. Subtilis Using CryoEM

    Hurst, P. J.; Morris, M. A.; Graham, A. A.; Nowick, J. S.; Patterson, J. P.

    ACS Omega 2021, 6, 27412-27417.

    DOIFree PDFPDFSupporting info

2020

  1. A Fluorescent Teixobactin Analogue

    Morris, M. A.; Malek, M.; Hashemian, M. H.; Nguyen, B. T.; Manuse S.; Lewis, K.; Nowick, J. S.

    ACS Chem. Biol. 2020, 15, 1222-1231.

    DOIFree PDFPDFSupporting info

  2. Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, & HCTU

    McKnelly, K. J.; Sokol, W.; Nowick, J. S.

    J. Org. Chem. 2020, 85, 1764-1768.

    DOIPDFSupporting info

  3. Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin

    Yang, H; Pishenko, A. V.; Li, X.; Nowick, J. S.

    J. Org. Chem. 2020, 85, 1331-1339.

    DOIFree PDFPDFSupporting infoPDB 6PSL

  4. Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ

    Samdin, T. D.; Wierzbicki, M.; Kreutzer, A. G.; Howitz, W. J.; Valenzuela, M.; Smith, A.; Sahrai, V. S.; Truex, N. L.; Klun, M.; Nowick, J. S.

    J. Am. Chem. Soc. 2020, 142, 11593-11601.

    DOIFree PDFPDFSupporting infoPDB 6VU4

  5. Interpreting Cubes in the X-Ray Crystallographic Structure of a Peptide Derived from Medin19–36

    Howitz, W. J.; Wierzbicki, M.; Cabanela, R. W.; Saliba, C.; Motovalli, A.; Tran, N.; Nowick, J. S.

    J. Am. Chem. Soc. 2020, 142, 15870-15875.

    DOIFree PDFPDFSupporting infoPDB 7JRH

  6. Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ

    Haerianardakani, S.; Kreutzer, A. G.; Salveson, P.; Samdin, T. D.; Guaglianone, G. E.; Nowick, J. S.

    J. Am. Chem. Soc. 2020, 142, 20708-20716.

    DOIFree PDFPDFSupporting infoPDB 7JXNPDB 7JXO

  7. Structural Interaction of Apolipoprotein A-I Mimetic Peptide with Amyloid-β Generates Toxic Hetero-oligomers

    Sahoo, B. R.; Bekier, M. E., II; Liu, Z.; Kocman, V.; Stoddard, A. K.; Anantharamaiah, G. M.; Nowick, J.; Fierke, C.; Wang, Y.; Ramamoorthy, A.

    J. Mol. Biol. 2020, 432, 1020-1034.

    DOIFree PDFSupporting info

  8. X-Ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16–36 that Assemble to Form Different Tetramers

    Kreutzer, A. G.; Samdin, T. D.; Guaglianone, G.; Spencer, R. K.; Nowick, J. S.

    ACS Chem. Neurosci. 2020, 11, 2340-2347.

    DOIFree PDFPDFSupporting infoPDB 6WXM

2019

  1. Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation

    Lu, J.; Cao, Q.; Wang, C.; Zheng, J.: Luo, F.; Xie, J.; Li, Y.; Ma, X.; He, L.; Eisenberg, D.; Nowick, J.; Jiang, L.; Li, D.

    Front. Mol. Neurosci. 2019, 12, 54.

    DOIFree PDF

2018

  1. An efficient method for the expression and purification of Aβ(M1–42)

    Yoo, S.†; Zhang, S.†; Kreutzer, A. G.; Nowick, J. S.

    Biochemistry 2018, 57, 3861-3866.

    contributed equally to this work.

    DOIFree PDFPDFSupporting info

  2. Controlling the Oligomerization State of Aβ-derived Peptides with Light

    Salveson, P. J.; Haerianardakani, S.; Thuy-Boun, A.; Kreutzer, A. G.; Nowick, J. S.

    J. Am. Chem. Soc. 2018, 140, 5842-5852.

    DOIFree PDFPDFSupporting infoPDB 6CG3PDB 6CG4PDB 6CG5

  3. Effects of Charge and Hydrophobicity on the Oligomerization of Peptides Derived from IAPP

    Wang, Y.; Truex, N. L.; Vo, N. D. P.; Nowick, J. S.

    Bioorganic Med. Chem. 2018, 26, 1151-1156.

    DOISupporting info

  4. Elucidating the Structures of Amyloid Oligomers with Macrocyclic β-Hairpin Peptides: Insights into Alzheimer's Disease and other Amyloid Diseases

    Kreutzer, A. G.; Nowick, J. S.

    Acc. Chem. Res. 2018, 51, 706-718.

    DOIFree PDFPDFSupporting info

  5. Repurposing triphenylmethane dyes to bind to trimers derived from Aβ

    Salveson, P. J.; Haerianardakani, S.; Thuy-Boun, A.; Yoo, S.; Kreutzer, A. G.; Nowick, J. S.

    J. Am. Chem. Soc. 2018, 140, 11745-11754. Correction: J. Am. Chem. Soc. 2018, 140, 15546-15546.

    DOIFree PDFPDFSupporting infoPDB 6DR4PDB 6DR5PDB 6DR6

  6. Structural Polymorphs Suggest Competing Pathways for the Formation of Amyloid Fibrils That Diverge from a Common Intermediate Species

    Buchanan, l. E.; Maj, M.; Dunkelberger, E. B.; Cheng, P.-N.; Nowick, J. S.; Zanni, M. T.

    Biochemistry 2018, 57, 6470–6478.

    DOIFree PDFPDFSupporting info

  7. X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly

    Yang, H; Wierzbicki, M.; Du Bois, D. R.; Nowick, J. S.

    J. Am. Chem. Soc. 2018, 140, 14028-14032.

    DOIFree PDFPDFSupporting infoPDB 6E00

2017

  1. A Hexamer of a Peptide Derived from Aβ 16–36

    Kreutzer, A. G.; Spencer, R. K.; McKnelly, K. J.; Yoo, S.; Hamza, I. L.; Salveson, P. J.; Nowick, J. S.

    Biochemistry 2017, 56, 6061-6071.

    DOIFree PDFPDFSupporting infoPDB 5W4HPDB 5W4IPDB 5W4J

  2. A Tetramer Derived from Islet Amyloid Polypeptide

    Wang, Y.; Kreutzer, A. G.; Truex, N.L.; Nowick, J. S.

    J. Org. Chem. 2017, 82, 7905-7912.

    DOIFree PDFPDFSupporting infoPDB 5UHR

  3. Alanine Scan Reveals Modifiable Residues in Teixobactin

    Chen, K.H.; Le, S. P.; Han, X.; Frias, J. M.; Nowick, J. S.

    Chem. Commun. 2017, 53, 11357-11359.

    DOIFree PDFPDFSupporting info

  4. Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ

    Kreutzer, A. G.; Yoo, S.; Spencer, R. K.; Nowick, J. S.

    J. Am. Chem. Soc. 2017, 139, 966-975.

    DOIFree PDFPDFSupporting infoPDB 5SURPDB 5SUSPDB 5SUTPDB 5SUU

  5. Transmembrane Proteins: Amyloids Hidden in Plain Sight?

    Truex, N. L.; Nowick, J. S.

    Biochemistry 2017, 56, 4735-4736.

    DOIFree PDFPDF

  6. X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Aβ16–36

    Salveson, P. J†.; Spencer, R. K.†; Kreutzer, A. G.†; Nowick, J. S.

    Org. Lett. 2017, 19, 3462-3465.

    contributed equally to this work.

    DOIFree PDFPDFSupporting infoPDB 5V63PDB 5V64PDB 5V65

  7. X-ray Crystallographic Structure of a Giant Double-Walled Peptide Nanotube Formed by a Macrocyclic β-Sheet Containing Aβ16–22

    Chen, K. H.; Corro, K. A.; Le, S. P.; Nowick, J. S.

    J. Am. Chem. Soc. 2017, 139, 8102-8105.

    DOIPDFSupporting infoPDB 5VF1

  8. X-ray Crystallographic Structure of a Teixobactin Analogue Reveals Key Interactions of the Teixobactin Pharmacophore

    Yang, H.; Du Bois, D. R.; Ziller, J. W.; Nowick, J. S.

    Chem. Commun. 2017, 53, 2772-2775. cif.

    DOIFree PDFPDFSupporting info

2016

  1. Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid

    Truex, N. L.; Wang, Y.; Nowick, J. S.

    J. Am. Chem. Soc. 2016, 138, 13882-13890.

    DOIFree PDFPDFSupporting info

  2. Coassembly of Peptides Derived from β-Sheet Regions of β-Amyloid

    Truex, N. L.; Nowick, J. S.

    J. Am. Chem. Soc. 2016, 138, 13891-13900.

    DOIFree PDFPDFSupporting info

  3. Elucidation of the Teixobactin Pharmacophore

    Yang, H.; Chen, K. H.; Nowick, J. S.

    ACS Chem. Biol. 2016, 11, 1823-1826.

    DOIFree PDFPDF

  4. Square channels formed by a peptide derived from transthyretin

    Yoo, S.; Kreutzer A. G.; Truex, N. L.; Nowick, J. S.

    Chem. Sci. 2016, 7, 6946-6951.

    DOIFree PDFPDFPDB 5HPP

  5. X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17-36 β-Hairpin

    Kreutzer, A. G.; Hamza, I. L.; Spencer, R. K.; Nowick, J. S.

    J. Am. Chem. Soc. 2016, 138, 4634-4642.

    DOIFree PDFPDFSupporting infoPDB 5HOWPDB 5HOXPDB 5HOY

  6. X-ray crystallographic structure of oligomers formed by a toxic β-hairpin derived from α-synuclein: trimers and higher-order oligomers

    Salveson, P. J.; Spencer, R. K.; Nowick, J. S.

    J. Am. Chem. Soc. 2016, 138, 4458-4467.

    DOIFree PDFPDFSupporting infoPDB 5F1TPDB 5F1W

2015

  1. A Newcomer’s Guide to Peptide Crystallography

    Spencer, R. K.; Nowick, J. S.

    Israel J. Chem. 2015, 55, 698-710.

    DOIFree PDFPDF

  2. Diversification of β-Augmentation Interactions between CDI Toxin/Immunity Proteins

    Morse, R. P.; Willett, J. L. E.; Johnson, P. M.; Zheng, J.; Credali, A.; Iniguez, A.; Nowick, J. S.; Hayes, C. S.; Goulding. C. W.

    J. Mol. Biol. 2015, 427, 3766-3784.

    DOIFree PDFSupporting infoPDB 4ZQUPDB 4ZQVPDB 4ZQW

  3. X-ray Crystallographic Structures of Oligomers of Peptides Derived from β2-Microglobulin

    Spencer, R. K.; Kreutzer, A. G.; Salveson, P. J.; Li, H.; Nowick, J. S.

    J. Am. Chem. Soc. 2015, 137, 6304-6311.

    DOIFree PDFPDFSupporting infoPDB 4P4VPDB 4P4WPDB 4P4XPDB 4P4YPDB 4P4ZPDB 4WC8PDB 4X0S

2014

  1. A Fibril-like Assembly of Oligomers of a Peptide Derived from β-Amyloid

    Pham, J. D.; Spencer, R. K.; Chen, K. H.; Nowick, J. S.

    J. Am. Chem. Soc. 2014, 136, 12682-12690.

    DOIFree PDFPDFSupporting infoPDB 4Q8D

  2. Polymorphism of Oligomers of a Peptide from β-Amyloid

    Pham, J. D.; Demeler, B.; Nowick, J. S.

    J. Am. Chem. Soc. 2014, 136, 5432–5442.

    DOIFree PDFPDFSupporting info

  3. X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Aβ17–36

    Spencer, R.; Li, H.; Nowick, J. S.

    J. Am. Chem. Soc. 2014, 136, 5595–5598.

    DOIFree PDFPDFSupporting infoPDB 4NTPPDB 4NTRPDB 4NW8PDB 4NW9

2013

  1. A Hydrophobic Surface is Essential to Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

    Zheng, J.; Baghkhanian, A. M.; Nowick, J. S.

    J. Am. Chem. Soc. 2013, 135, 6846-6852.

    DOIPDFSupporting info

  2. Mechanism of IAPP Amyloid Fibril Formation Involves an Intermediate with a Transient β-Sheet

    Buchanan, L. E.; Dunkelberger, E. B.; Tran, H. Q.; Cheng, P.-N.; Chiu, C.-C.; Cao, P.; Raleigh, D. P.; de Pablo, J. J.; Nowick, J. S.; Zanni, M. T.

    Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19285-19290.

    DOIFree PDFPDFSupporting info

  3. Recipe for β-Sheets: Foldamers Containing Amyloidogenic Peptide Sequences

    Spencer, R.; Chen, K. H.; Manuel, G.; Nowick, J. S.

    Eur. J. Org. Chem. 2013, 3523-3528.

    DOIPDFSupporting info

  4. Structures of Oligomers of a Peptide from β-Amyloid

    Pham, J. D.; Chim, N.; Goulding, C. W.; Nowick, J. S.

    J. Am. Chem. Soc. 2013, 135, 12460-12467.

    DOIFree PDFPDFSupporting infoPDB 4IVH

  5. The Supramolecular Chemistry of β-Sheets

    Cheng, P.-N.; Pham, J. D.; Nowick, J. S.

    J. Am. Chem. Soc. 2013, 135, 5477–5492.

    DOIFree PDFPDF

2012

  1. Amyloid β-Sheet Mimics that Antagonize Protein Aggregation and Reduce Amyloid Toxicity

    Cheng, P.-N.; Liu, C.; Zhao, M.; Eisenberg, D.; Nowick, J. S.

    Nat. Chem. 2012, 4, 927-933.

    DOIFree PDFPDFSupporting infoPDB 3T4G

  2. Heterodivalent Linked Macrocyclic β-Sheets with Enhanced Activity against Aβ Aggregation: Two Sites are Better than One

    Cheng, P.-N.; Spencer, R.; Woods, R. J.; Glabe, C. G.; Nowick, J. S.

    J. Am. Chem. Soc. 2012, 133, 14179-14184.

    DOIFree PDFPDFSupporting info

  3. Litter decay rates are determined by lignin chemistry

    Talbot, J. M.; Yelle, D. J.; Nowick, J. S.; Treseder, K. K.

    Biogeochemistry 2012, 108, 279-295.

    DOI

  4. Out-of-Register β-Sheets Suggest a Pathway to Toxic Amyloid Aggregates

    Liu, C.; Zhao, M.; Jiang, L.; Cheng,P.-N.; Park, J.; Sawaya M.R.; Pensalfini, A.; Gou, D.; Berk A. J.; Glabe C. G.; Nowick, J. S.; Eisenberg. D.

    Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 20913-20918.

    DOIFree PDFPDFSupporting infoPDB 4E0KPDB 4E0LPDB 4E0MPDB 4E0NPDB 4E0O

2011

  1. Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics

    Liu, C.; Sawaya, M. R.; Cheng, P.-N.; Zheng, J.; Nowick, J. S.; Eisenberg, D.

    J. Am. Chem. Soc. 2011, 133, 6736-6744.

    DOIFree PDFPDFSupporting infoPDB 3Q9GPDB 3Q9HPDB 3Q9IPDB 3Q9J

  2. Giant Macrolactams Based on β-Sheet Peptides

    Cheng,P.-N.; Nowick, J. S.

    J. Org. Chem. 2011, 76, 3166-3173.

    DOIFree PDFPDFSupporting info

  3. Macrocyclic β-Sheet Peptides that Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide

    Zheng, J.; Liu, C.; Sawaya, M. R.; Vadla, B.; Khan, S.; Woods, R. J.; Eisenberg, D.; Goux, W. J.; Nowick, J. S.

    J. Am. Chem. Soc. 2011, 133, 3144-3157.

    DOIFree PDFPDFSupporting info

2010

  1. In Memoriam: Arthur Stanley Nowick

    Nowick, J. S.; Nowick, S. M.

    MRS Bulletin 2010, 35, 736-737.

    DOI

  2. Nanometer-Scale Water-Soluble Macrocycles from Nanometer-Sized Amino Acids

    Gothard, C. M.; Nowick, J. S.

    J. Org. Chem. 2010, 75, 1822-1830.

    DOIFree PDFPDFSupporting info

  3. Selective Heteronuclear Hartmann-Hahn: Multiple-Pulse Sequence for Selective Magnetization Transfer in the Structural Elucidation of "Isotagged" Oligosaccharides

    Meng, X.; Nguyen, W. H.; Nowick, J. S.; Shaka, A. J.

    J. Mag. Res. 2010, 203, 73-80.

    DOI

  4. X-ray Crystallographic Structure of an Artificial β-Sheet Dimer

    Khakshoor, O.; Lin, A. J.; Korman, T. P.; Sawaya, M. R.; Tsai, S.-C.; Eisenberg, D.; Nowick, J. S.

    J. Am. Chem. Soc. 2010, 132, 11622-11628.

    DOIFree PDFPDFPDB 3NI3

2009

  1. A New Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

    Levin, S.; Nowick, J. S.

    Org. Lett. 2009, 11, 1003-1006.

    DOIFree PDFPDFSupporting info

  2. Use of Disulfide "Staples" To Stabilize β-Sheet Quaternary Structure

    Khakshoor, O.; Nowick, J. S.

    Org. Lett. 2009, 11, 3000-3003.

    DOIFree PDFPDFSupporting info

2008

  1. Artificial β-Sheets: Chemical Models of β-Sheets

    Khakshoor, O.; Nowick, J. S.

    Curr. Opin. Chem. Biol. 2008, 12, 722-729.

    DOIFree PDF

  2. Exploring β-Sheet Structure and Interactions with Chemical Model Systems

    Nowick, J. S.

    Acc. Chem. Res. 2008, 41, 1319-1330.

    DOIFree PDFPDF

  3. Functionalized Analogues of an Unnatural Amino Acid that Mimics a Tripeptide β-Strand

    Khasanova, T. V.; Khakshoor, O.; Nowick, J. S.

    Org. Lett. 2008, 10, 5293-5296.

    DOIFree PDFPDFSupporting info

2007

  1. A New Class of Macrocyclic Receptors from iota-Peptides

    Kang, S.-W. Gothard, C. M.; Maitra, S.; Atia-tul-Wahab; Nowick, J. S.

    J. Am. Chem. Soc. 2007, 129, 1486-1487.

    DOIPDFSupporting info

  2. An Artificial β-Sheet that Dimerizes through Parallel β-Sheet Interactions

    Levin, S.; Nowick, J. S.

    J. Am. Chem. Soc. 2007, 129, 13043-13048.

    DOIFree PDFPDFSupporting info

  3. Cyclic Modular β-Sheets

    Woods, R. J.; Brower, J. O.; Castellanos, E.; Hashemzadeh, M.; Khakshoor, O.; Russu, W. A.; Nowick, J. S.

    J. Am. Chem. Soc. 2007, 129, 2548-2558.

    DOIFree PDFPDFSupporting info

  4. Macrocyclic β-Sheet Peptides that Mimic Protein Quaternary Structure through Intermolecular β-Sheet Interactions

    Khakshoor, O.; Demeler, B.; Nowick, J. S.

    J. Am. Chem. Soc. 2007, 129, 5558-5569.

    DOIFree PDFPDFSupporting info

  5. Nanometer-Sized Amino Acids for the Synthesis of Nanometer-Scale Water-Soluble Molecular Rods of Precise Length

    Gothard, C. M.; Rao, N. A.; Nowick, J. S.

    J. Am. Chem. Soc. 2007, 129, 7272-7273.

    DOIFree PDFPDFSupporting info

2006

  1. What I Have Learned by Using Chemical Model Systems to Study Biomolecular Structure and Interactions

    Nowick, J. S.

    Org. Biomol. Chem. 2006, 4, 3869-3885.

    DOIPDF

2005

  1. The Absence of Favorable Aromatic Interactions between β-Sheet Peptides

    Chung, D. M.; Dou, Y.; Baldi, P.; Nowick, J. S.

    J. Am. Chem. Soc. 2005, 127, 9998-9999.

    DOIPDF

2004

  1. Enantioselective Molecular Recognition between β-Sheets

    Chung, D. M.; Nowick, J. S.

    J. Am. Chem. Soc. 2004, 126, 3062-3063.

    DOIPDFSupporting info

  2. ICBS: A Database of Protein-Protein Interactions Mediated by β-Sheet Formation

    Dou, Y.; Baisnée, P.-F.; Pollastri, G.; Pécout, Y.; Nowick, J.; Baldi, P.

    Bioinformatics 2004, 20, 2767-2777.

2003

  1. A New Turn Structure for the Formation of β-Hairpins in Peptides

    Nowick, J. S.; Brower, J. O.

    J. Am. Chem. Soc. 2003, 125, 876-877.

    DOIPDF

  2. A Ribozyme with Michaelase Activity: Synthesis of the Substrate Precursors

    Eisenführ, A.; Arora, P. S.; Sengle, G.; Takaoka, L. R.; Nowick J. S.; Famulok, M.

    Bioorg. Med. Chem. 2003, 11, 235-249.

    DOI

  3. DSA: A New Internal Standard for NMR Studies in Aqueous Solution

    Nowick, J. S.; Khakshoor, O.; Hashemzadeh, M.; Brower, J. O.

    Org. Lett. 2003, 5, 3511-3513.

    DOIPDFSupporting info

  4. Dityrosine Crosslinked Aβ Peptides: Fibrillar Beta Structure in Aβ(1-40) is Conducive to Formation of Dityrosine Crosslinks, but a Dityrosine Crosslink in Aβ(8-14) does not Induce Beta Structure

    Yoburn, J. C.; Tian, W. Q.; Brower, J. O.; Nowick, J. S.; Glabe, C. G.; Van Vranken, D. L.

    Chem. Res. Toxicol. 2003, 16, 531-535.

    DOIPDF

  5. Sequence-Selective Molecular Recognition Between β-Sheets

    Nowick, J. S.; Chung, D. M.

    Angew. Chem., Int. Ed. 2003, 42, 1765-1768.

    DOIPDF

2002

  1. An Unnatural Amino Acid that Induces β-Sheet Folding and Interaction in Peptides

    Nowick, J. S.; Lam, K. S.; Khasanova, T. V.; Kemnitzer, W. E.; Maitra, S.; Mee, H. T.; Liu, R.

    J. Am. Chem. Soc. 2002, 124, 4972-4973.

    DOIPDFSupporting info

  2. Methylglyoxal Synthetase, enol-Pyruvaldehde, Glutathione, and the Glyoxalase System

    Rose, I. A.; Nowick, J. S.

    J. Am. Chem. Soc. 2002, 124, 13047-13052.

    DOIPDF

  3. Three-Stranded Mixed Artificial β-Sheets

    Nowick, J. S.; Smith, E. M.; Ziller, J. W.; Shaka, A. J.

    Tetrahedron 2002, 58, 727-739.

    DOI

2001

  1. A Triply Templated Artificial β-Sheet

    Nowick, J. S.; Cary, J. M.; Tsai, J. H.

    J. Am. Chem. Soc. 2001, 123, 5176-5180.

    DOIPDFSupporting info

  2. Novel RNA Catalysts for the Michael Reaction

    Sengle, G.; Eisenführ, A.; Arora, P. S.; Nowick, J. S.; Famulok, M.

    Chemistry & Biology 2001, 8, 459-473.

    DOI

  3. Starving at the Banquet

    Nowick, J. S.

    Chem Eng. News 2001, 79(13), 178.

    PDF

2000

  1. An Unnatural Amino Acid that Mimics a Tripeptide β-Strand and Forms β-Sheetlike Hydrogen-Bonded Dimers

    Nowick, J. S.; Chung, D. M.; Maitra, K.; Maitra, S.; Stigers, K. D.; Sun, Y.

    J. Am. Chem. Soc. 2000, 122, 7654-7661.

    DOIPDF

  2. Fmoc*: A More Soluble Analogue of the 9-Fluorenylmethoxycarbonyl Protecting Group

    Stigers, K. D.; Koutroulis, M. R.; Chung, D. M.; Nowick, J. S.

    J. Org. Chem. 2000, 65, 3858-3860.

    DOIPDF

  3. Synthesis of Amino Acid Ester Isocyanates: Methyl (S)-2-Isocyanato-3-phenylpropanoate

    Tsai, J. H.; Takaoka, L. R.; Powell, N. A.; Nowick, J. S.

    Org. Synth. 2000, 78, 220-224.

    PDFJournal

  4. Synthesis, Incorporation Efficiency, and Stability of Disulfide Bridged Functional Groups at RNA 5'-Ends

    Sengle, G.; Jenne, A.; Arora, P. S.; Selig, B.; Nowick, J. S.; Jäschke, A.; Famulok, M.

    Bioorg. Med. Chem. 2000, 8, 1317-1329.

    DOI

1999

  1. A Chemical Model of a Protein β-Sheet Dimer

    Nowick, J. S.; Tsai, J. H.; Bui, Q.-C. D.; Maitra, S.

    J. Am. Chem. Soc. 1999, 121, 8409-8410.

    DOIPDF

  2. A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn

    Soth, M. J.; Nowick, J. S.

    J. Org. Chem. 1999, 64, 276-281.

    DOIPDF

  3. Chemical Models of Protein β-Sheets

    Nowick, J. S.

    Acc. Chem. Res. 1999, 32, 287-296.

    DOIPDF

  4. Designed Molecules that Fold to Mimic Protein Secondary Structures

    Stigers, K. D.; Soth, M. J.; Nowick, J. S.

    Curr. Opin. Chem. Biol. 1999, 3, 714-723.

    DOI

  5. Folding of an Artificial β-Sheet in Competitive Solvents

    Junquera, E.; Nowick, J. S.

    J. Org. Chem. 1999, 64, 2527-2531.

    DOIPDF

  6. Two New β-Strand Mimics

    Tsai, J. H.; Waldman, A. S.; Nowick, J. S.

    Bioorg. Med. Chem. 1999, 7, 29-38.

    DOI

1998

  1. An Efficient Synthesis of N,N'-Linked Oligoureas

    Wilson, M. E.; Nowick, J. S.

    Tetrahedron Lett. 1998, 39, 6613-6616.

    DOIPDF

  2. Design and Synthesis of a Transition State Analog for the Diels-Alder Reaction

    Arora, P. S; Van, Q. N.; Famulok, M.; Shaka, A. J.; Nowick, J. S.

    Bioorg. Med. Chem. 1998, 6, 1421-1428.

    DOI

  3. The Alginate Demonstration: Polymers, Food Science, and Ion Exchange

    Waldman, A. S.; Schechinger, L.; Govindarajoo, G.; Nowick, J. S.; Pignolet, L. H.

    J. Chem. Educ. 1998, 75, 1430-1431.

    DOIPDF

1997

  1. An Artificial Antiparallel β-Sheet Containing a New Peptidomimetic Template

    Smith, E. M.; Holmes, D. L.; Shaka, A. J.; Nowick, J. S.

    J. Org. Chem. 1997, 62, 7906-7907.

    DOIPDF

  2. An Extended β-Strand Mimic for a Larger Artificial β-Sheet

    Nowick, J. S.; Pairish, M.; Lee, I. Q.; Holmes, D. L.; Ziller, J. W.

    J. Am. Chem. Soc. 1997, 119, 5413-5424.

    DOIPDF

  3. Model Behaviour

    Nowick, J. S.

    Chem. Br. 1997, 33(12), 36-39.

  4. Solid-Phase Synthesis of Artificial β-Sheets

    Holmes, D. L.; Smith, E. M.; Nowick, J. S.

    J. Am. Chem. Soc. 1997, 119, 7665-7669.

    DOIPDF

  5. The Propensities of Amino Acids to Form Parallel β-Sheets

    Nowick, J. S.; Insaf, S.

    J. Am. Chem. Soc. 1997, 119, 10903-10908.

    DOIPDFSupporting info

  6. Unnatural Oligomers and Oligomer Libraries

    Soth, M. J.; Nowick, J. S.

    Current Opinion in Chemical Biology 1997, 1, 120-129.

    DOI

1996

  1. A Coordinated Chemistry Outreach Program that Reaches Thousands of High School Students

    Waldman, A. S.; Schechinger, L.; Nowick, J. S.

    J. Chem. Educ. 1996, 73, 762-764.

    DOIPDF

  2. An Artificial β-Sheet Comprising a Molecular Scaffold, a β-Strand Mimic, and a Peptide Strand

    Nowick, J. S.; Holmes, D. L.; Mackin, G.; Noronha, G.; Shaka, A. J.; Smith, E. M.

    J. Am. Chem. Soc. 1996, 118, 2764-2765.

    DOIPDF

  3. Artificial β-Sheets

    Nowick, J. S.; Smith, E. M.; Pairish, M.

    Chem. Soc. Rev. 1996, 25, 401-415.

    DOIPDF

  4. Synthesis of Peptide Isocyanates and Isothiocyanates

    Nowick, J. S.; Holmes, D. L.; Noronha, G.; Smith, E. M.; Nguyen, T. M.; Huang, S.-L.

    J. Org. Chem. 1996, 61, 3929-3934. Addition: J. Org. Chem. 1998, 63, 9144.

    DOIPDF

  5. Triurea Derivatives of Diethylenetriamine as Potential Templates for the Formation of Artificial β-Sheets

    Nowick, J. S.; Mahrus, S.; Smith, E. M.; Ziller, J. W.

    J. Am. Chem. Soc. 1996, 118, 1066-1072.

    DOIPDFSupporting info

1995

  1. A Novel Hydrogen-Bonded Dimer Containing a Sixteen-Membered Ring

    Nowick, J. S.; Antonovich, V.; Noronha, G.; Ziller, J. W.

    J. Org. Chem. 1995, 60, 1888.

    DOIPDF

  2. Molecular Scaffolds 3. An Artificial Parallel β-Sheet

    Nowick, J. S.; Smith, E. M.; Noronha, G.

    J. Org. Chem. 1995, 60, 7386-7387.

    DOIPDF

  3. Molecular Scaffolds. 2. Intramolecular Hydrogen Bonding in 1,2-Diaminoethane Diureas

    Nowick, J. S.; Abdi, M.; Bellamo, K. A.; Love, J. A.; Martinez, E. J.; Noronha, G.; Smith, E. M.; Ziller, J. W.

    J. Am. Chem. Soc. 1995, 117, 89-99.

    DOIPDF

1994

  1. Molecular Recognition Between Uncharged Molecules in Aqueous Micelles

    Nowick, J. S.; Cao, T.; Noronha, G.

    J. Am. Chem. Soc. 1994, 116, 3285-3289.

    DOIPDF

1993

  1. Molecular Recognition in Micelles: The Roles of Hydrogen Bonding and Hydrophobicity in Adenine-Thymine Base-Pairing in SDS Micelles

    Nowick, J. S.; Chen, J. S.; Noronha, G.

    J. Am. Chem. Soc. 1993, 115, 7636-7644.

    DOIPDF

1992

  1. An Improved Method for the Synthesis of Enantiomerically Pure Amino Acid Ester Isocyanates

    Nowick, J. S.; Powell, N. A.; Nguyen, T. M.; Noronha, G.

    J. Org. Chem. 1992, 57, 7364-7366.

    DOIPDF

  2. Molecular Recognition in Aqueous Micellar Solution: Adenine-Thymine Base-Pairing in SDS Micelles

    Nowick, J. S.; Chen, J. S.

    J. Am. Chem. Soc. 1992, 114, 1107-1108.

    DOIPDF

  3. Molecular Scaffolds I. Intramolecular Hydrogen Bonding in a Family of Di- and Triureas

    Nowick, J. S.; Powell, N. A.; Martinez, E. J.; Smith, E. M.; Noronha, G.

    J. Org. Chem. 1992, 57, 3763-3765.

    DOIPDFSupporting info

  4. Self-Replicating Systems

    Famulok, M.; Nowick, J. S.; Rebek, J, Jr.

    Acta Chem. Scand. 1992, 46, 315.

    DOIPDF

1991

  1. A Practical and Efficient Method for the Synthesis of β-Lactones

    Danheiser, R. L.; Nowick, J. S.

    J. Org. Chem. 1991, 56, 1176.

    DOIPDF

  2. Kinetic Studies and Modeling of a Self-Replicating System

    Nowick, J. S.; Feng, Q.; Tjivikua, T.; Ballester, P.; J. Rebek, J., Jr.

    J. Am. Chem. Soc. 1991, 113, 8831.

    DOIPDF

1990

  1. Convergent Functional Groups. 9. Complexation in New Molecular Clefts

    Nowick, J. S.; Ballester, P.; Ebmeyer, F.; Rebek, J. Jr.

    J. Am. Chem. Soc. 1990, 112, 8902.

    DOIPDF

1989

  1. Application of (α-Phosphonoacyl)silane Reagents to the Synthesis of α,β-Unsaturated Acylsilanes

    Nowick, J. S.; Danheiser, R. L.

    J. Org. Chem. 1989, 54, 2798.

    DOIPDF

  2. Synthesis of Conjugated Optically Active Polymetallocenes

    Katz, T. J.; Sudhakar, A.; Yang, B.; Nowick, J. S.

    J. Macromol. Sci., Chem. 1989, A26, 309.

    DOI

  3. The M.I.T. Chemistry Outreach Program: Graduate Students Presenting Chemistry to High School Students

    Nowick, J. S.; Brisbois, R. G.

    J. Chem. Educ. 1989, 66, 668.

    DOIPDF

1988

  1. Chemistry of Cyclopropylacylsilanes I. α-Functionalized Acylsilane Reagents for the Cyclopropanation of Electrophilic Alkenes

    Nowick, J. S.; Danheiser, R. L.

    Tetrahedron 1988, 44, 4113.

    DOI

1984

  1. Application of Chiral Lanthanide-Induced Shift Reagents to Optically Active Cations: The Use of Tris[3-(trifluoromethylhydroxymethylene)-(+)-camphorato]europium(III) to Determine the Enantiomeric Purity of Tris(phenanthroline)ruthenium(II) Dichloride

    Barton, J. A.; Nowick, J. S.

    J. Chem. Soc., Chem. Commun. 1984, 1650.

    DOIPDF