Larry E. OvermanProfessor, Chemistry Distinguished Professor of Chemistry |
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Research Interests |
Organic, Inorganic, Organometallic and Chemical Biology | |
| URL | Overman Group Website | |
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Academic Distinctions | American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010, Tetrahedron Prize for Creativity in Organic Chemistry, 2008, The Nagoya Medal of Organic Chemistry, 2007, International Society of Heterocyclic Chemistry Senior Award, 2005, Ta-shue Chou Lectureship Award, 2004, American Chemical Society Arthur C. Cope Award, 2003, U.C. Irvine Distinguished Faculty Lectureship Award for Research, 2002-2003, Yamada Prize, 2002, 2000 Japan Society for the Promotion of Science Fellowship, 1999 S. T. Li Prize for Achievements in Science and Technology, Earlham College Distinguished Faculty Award 1999, Centenary Medal, Chemical Society, U.K., 1997, American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995, Guggenheim Fellowship, 1993-1994, C.S. Hamilton Award, University of Nebraska, 1993, Javits Neuroscience Investigator Award, 1985-1992; 1992-1999, American Chemical Society Arthur C. Cope Scholar Award, 1989, Visiting Miller Research Fellow, U.C. Berkeley, 1989, Alexander von Humboldt U.S. Senior Scientist Award, 1985-1987, Camille and Henry Dreyfus Teacher-Scholar Award, 1976-1981, U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981, U.C. Irvine Alumni Association Distinguished Research Award, 1979, Alfred P. Sloan Foundation Fellow, 1975-1977 | |
| Appointments |
NIH Postdoctoral Fellow, Columbia University, 1969-1971 Joined UCI Faculty in 1971 |
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Research Abstract |
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Transition metal catalyzed reactions play a prominent role in our methodological studies. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. | |
| Publications |
A Unified Strategy for Enantioselective Total Synthesis of Cladiellin and Briarellen Diterpenes: Total Synthesis of Briarellins E and F, and the Putative Structure of Alcyonin and Revision of Its Structure Assignment Journal of Organic Chemistry 2009, in press O. Corminboeuf, L. E. Overman and L. D. Pennington |
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Molecular Rearrangements in the Construction of Complex Molecules Tetrahedron 2009, in press L. E. Overman |
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Absolute Configuration of Actinophyllic Acid as Determined through Chiroptical Data Journal of Natural Products 2009, 72, 430432. T. Taniguchi, C. L. Martin, K. Monde, K. Nakanishi, N. Berova and L. E. Overman |
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A Versatile Synthesis of Unsymmetrical 3,3'-Bioxindoles: Stereoselective Mukaiyama Aldol Reactions of 2-Siloxyindoles with Isatins Journal of Organic Chemistry 2008, 73, 91519154 J. M. Ellis, L. E. Overman, H. R. Tanner and J. Wang |
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Enantioselective Total Syntheses of Nankakurines A and B: Confirmation of Structure and Establishment of Absolute Configuration Journal of the American Chemical Society 2008, 130, 1129711299 B. L. Nilsson, L. E. Overman, J. Read de Alaniz and J. M. Rohde |
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Total Synthesis of (+)-Actinophyllic Acid Journal of the American Chemical Society 2008, 130, 75687569 C. L. Martin, L. E. Overman and J. M. Rohde |
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Catalytic Asymmetric Synthesis of Allylic Thiol Derivatives Organic Letters 2008, 10, 14851488 L. E. Overman, S. W. Roberts and H. Sneddon |
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Total Synthesis of the Strychnos Alkaloid (+)Minfiensine: Tandem Enantioselective Intramolecular Heck-Iminium Ion Cyclization Journal of the American Chemical Society 2008, 130, 53685377 A. B. Dounay, P. G. Humphreys, L. E. Overman and A. D. Wrobleski |
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Construction of Epidithiodioxopiperazines by Directed Oxidation of Hydroxyproline-Derived Dioxopiperazines Organic Letters 2007, 9, 52675270 L. E. Overman and T. Sato |
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On the Structure of Palauamine: Evidence for the Revised Relative Configuration from Chemical Synthesis Journal of the American Chemical Society 2007, 129, 1289612900 B. A. Lanman, L. E. Overman, R. Paulini and N. S. White |
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Professional Societies |
American Chemical Society American Association for the Advancement of Sciences National Academy of Sciences American Academy of Arts & Sciences |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=2042 | |
| Last updated | 10/08/2009 | |
