Robert M. CornProfessor, Chemistry |
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Research Interests |
Surface Chemistry, Surface Spectroscopy, Surface Biochemistry, Biosensors, FTIR, SPR, SHG, DNA Computing, Liquid-Liquid Interfaces | |
| URL | corninfo.ps.uci.edu | |
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Academic Distinctions |
2007 Pittsburgh Spectroscopy Award 2007 ACS Division of Analytical Chemistry Award in Spectrochemical Analysis 2007 AAAS Fellow |
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| Appointments | Visiting Scientist at the IBM Research Laboratory in San Jose, California, 1983-1984 | |
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Research Abstract |
Professor Corn's area of expertise is the study of chemistry at condensed phase interfaces. Specific areas of research include the use of surface plasmon resonance (SPR) to monitor biopolymer adsorption, the chemical modification of surfaces with self-assembled monolayers for the creation of adsorption-based biosensors, the characterization of molecular monolayers at metal surfaces by polarization-modulation FTIR reflection absorption spectroscopy (PM-FTIRRAS), and optical second harmonic generation (SHG) measurements of orientation, organization, and electron transfer processes at liquid/liquid electrochemical interfaces. Prof. Corn also has ongoing research projects in the implementation of DNA computing algorithms at surfaces, and the fabrication of multilayer polyelectrolyte films for ion transport applications. | |
| Publications |
Alastair Wark, Hye Jin Lee and Robert M. Corn,"Multiplexed Detection Methods for Profiling microRNA Expression in Biological Samples," Angewandte Chemie, 47 644-652 (2008). |
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Yuan Li, Hye Jin Lee, and Robert M. Corn, "Detection of Protein Biomarkers using RNA Aptamer Microarrays and Enzymatically Amplified SPR Imaging," Analytical Chem., 79 1082-1088 (2007). |
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Alastair Wark, Abraham Qavi, Hye Jin Lee, and Robert M. Corn, "Nanoparticle-Enhanced Diffraction Gratings for Ultrasensitive Surface Plasmon Biosensing," Analytical Chem., 79 6697 - 6701 (2007). |
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Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Ultra-Sensitive Microarray Detection of DNA using Enzymatically Amplified SPR Imaging," in New Frontiers in Ultrasensitive Bioanalysis: Advanced Analytical Chemistry Applications in Nanobiotechnology, Single Molecule Detection, and Single Cell Analysis, Nancy Xu, ed., Wiley-Interscience, 2007, ISBN: 978-0-471-74660-7 pp. 169-194. |
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Hye Jin Lee, Alastair Wark and Robert M. Corn, "Utilizing ultrathin DNA/poly-lysine multilayer films to create liquid/liquid interfaces: spectroscopic characterization, interfacial reactions and nanoparticle adsorption," J. Physics: Condensed Matter 19 Article No. 375107 (2007). |
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R. Zadoyan, H. Ye. Seferyan, A. W. Wark, R. M. Corn, and V. A. Apkarian, "Interfacial Velocity-Dependent Plasmon Damping in Colloidal Metallic Nanoparticles," J. Phys. Chem. C, 111 10836-10840 (2007). |
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| Shiping Fang, Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Attomole Detection of microRNAs by Nanoparticle-Amplified SPR Imaging Measurements of Surface Polyadenylation Reactions," J. Am. Chem. Soc., 128 14044-14046 (2006). | ||
| Yuan Li, Hye Jin Lee, and Robert M. Corn, "Fabrication and characterization of RNA aptamer microarrays for the study of protein-aptamer interactions with SPR imaging," Nucleic Acids Research, 34 6416-6424 (2006). | ||
| Hye Jin Lee, Dobrin Nedelkov and Robert M. Corn, "SPR Imaging Measurements of Antibody Arrays for the Multiplexed Detection of Low Molecular Weight Protein Biomarkers," Analytical Chem., 78 6504-6510 (2006). | ||
| Hye Jin Lee, Alastair W. Wark and Robert M. Corn, "Creating Advanced Multifunctional Biosensors with Surface Enzymatic Transformations," Langmuir, 22 5241-5250 (2006). | ||
| Yuan Li, Alastair W. Wark, Hye Jin Lee and Robert M. Corn, "Single Nucleotide Polymorphism Genotyping by Nanoparticle-Enhanced SPR Imaging Measurements of Surface Ligation Reactions," Analytical Chem., 78 3158-3164 (2006). | ||
| Hye Jin Lee, Alastair W. Wark, Yuan Li and Robert M. Corn, "Fabricating RNA Microarrays with RNA-DNA Surface Ligation Chemistry," Analytical Chem., 77 7832-7837 (2005). | ||
| Shiping Fang, Hye Jin Lee, Alastair W. Wark, Hyun Min Kim and Robert M. Corn, "Determination of Ribonuclease H Surface Enzyme Kinetics by Surface Plasmon Resonance Imaging and Surface Plasmon Fluorescence Spectroscopy," Analytical Chem., 77 6528-6534 (2005). | ||
| Hye Jin Lee, Yuan Li, Alastair W. Wark and Robert M. Corn, "Enzymatically Amplified SPR Imaging Detection of DNA by Exonuclease III Digestion of DNA Microarrays," Analytical Chem., 77 5096-5100 (2005). | ||
| Alastair W. Wark, Hye Jin Lee, and Robert M. Corn, "Long-Range Surface Plasmon Resonance Imaging for Bioaffinity Sensors," Analytical Chem., 77 3904-3907 (2005). | ||
| Hye Jin Lee, Alastair W. Wark, Terry T. Goodrich, Shiping Fang and Robert M. Corn, "Surface Enzyme Kinetics for Biopolymer Microarrays: A Combination of Langmuir and Michaelis-Menten Concepts," Langmuir, 21 4050 - 4057 (2005). | ||
| Terry T. Goodrich, Hye Jin Lee, and Robert M. Corn, "Enzymatically Amplified Surface Plasmon Resonance Imaging Method Using RNase H and RNA Microarrays for the Ultrasensitive Detection of Nucleic Acids," Anal. Chem., 76 6173-6178 (2004). | ||
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Greta J. Wegner, Alastair W. Wark, Hye Jin Lee, Eric Codner, Tomonori Saeki, Shiping
Fang, and Robert M. Corn,
"Real-Time Surface Plasmon Resonance Imaging Measurements for the Multiplexed Determination of Protein
Adsorption/Desorption Kinetics and Surface Enzymatic Reactions on Peptide Microarrays,"
Anal. Chem., 76 5667-5684 (2004). |
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| Terry T. Goodrich, Hye Jin Lee, and Robert M. Corn," Direct Detection of Genomic DNA by Enzymatically Amplified SPR Imaging Measurements of RNA Microarrays," J. Am. Chem. Soc., 126, 4086-4087 (2004). | ||
| Greta J. Wegner, Hye Jin Lee, Gerard Marriott, and Robert M.Corn, "Fabrication of Histidine-Tagged Fusion Protein Arrays for Surface Plasmon Resonance Imaging Studies of Protein-Protein and Protein-DNA Interactions," Anal. Chem., 75 4740-4746 (2003). | ||
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Emily A. Smith, William D. Thomas, Laura L. Kiessling, and Robert M. Corn, "Surface Plasmon Resonance Imaging Studies of Protein-Carbohydrate Interactions," J. Am. Chem. Soc., 125 6140-6148 (2003). |
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| Emily A. Smith, Matthew G. Erickson, Andrew T. Ulijasz, Bernard Weisblum, and Robert M. Corn, "Surface Plasmon Resonance Imaging of Transcription Factor Proteins: Interactions of Bacterial Response Regulators with DNA Arrays on Gold Films," Langmuir, 19 1486-1492 (2003). | ||
| Greta J. Wegner, Hye Jin Lee and Robert M. Corn, "Characterization and Optimization of Peptide Arrays for the Study of Epitope-Antibody Interactions Using Surface Plasmon Resonance Imaging," Anal. Chem., 74 5161-5168 (2002). | ||
| Emily A. Smith, Motoki Kyo, Hiroyuki Kumasawa, Kazuhiko Nakatani, Isao Saito, and Robert M. Corn, "Chemically Induced Hairpin Formation in DNA Monolayers," J. Am. Chem. Soc., 124 6810-6811 (2002). | ||
| Ming Li, Hye Jin Lee, Anne E. Condon and Robert M. Corn, "A DNA Word Design Strategy for Creating Sets of Non-Interacting Oligonucleotides for DNA Microarrays," Langmuir, 73 805-812 (2002). | ||
| Amit Marathe, Anne E. Condon, Robert M. Corn, "On Combinatorial DNA Word Design," J. Computational Biology, 8 201-219 (2001). | ||
| Hye Jin Lee, Terry T. Goodrich and Robert M. Corn,"Surface Plasmon Resonance Imaging Measurements of 1D and 2D DNA Microarrays Created from Microfluidic Channels on Gold Thin Films," Analytical Chemistry, 73 5525-5531 (2001). | ||
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Professional Societies |
Sigma Xi American Chemical Society Society for Applied Spectroscopy International Society of Electrochemistry |
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| Other Experience |
Professor University of Wisconsin 1985—2004 |
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Joined UCI Faculty in 2004 |
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| Graduate Programs |
Chemistry Biomedical Engineering |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5123 | |
| Last updated | 03/13/2008 | |
