The Prescher Lab

Expanding the imaging toolkit to spy on cellular communication


Our research team is crafting novel probes to "spy" on cells and decipher their communications in vivo. Cellular networks drive diverse aspects of human biology, ranging from immune function to memory formation. Breakdowns in these networks also underlie numerous pathologies. While cell-cell interactions play key roles in human health and disease, the mechanisms by which cells transact information in vivo are not completely understood. The number of cells types involved, the timing and location of their interactions, the molecular cues exchanged, and the long-term fates of the cells remain poorly characterized in most cases. We are designing and deploying custom tools to visualize cellular networks in real time—and with molecular precision—in physiologically relevant environments. Collectively, our work is decoding cellular communications relevant to infectious disease, cancer metastases, and immune function.


News and Events

March 2021

  • Undergraduate researcher Landon Taylor has accepted Boston College’s offer of admission to graduate school! Congrats Landon!
  • Undergraduate alumna Elena Helm will be attending graduate school at NYU. Congratulations!
  • Lila Halbers officially joins the lab! Welcome!
  • Our report of a rapid, multicomponent imaging platform was published in ACS Chemical Biology. Congrats!
  • Kat won an NSF GRFP honorable mention! Congrats, Kat!

February 2021

  • Our work on developing disubstituted luciferins as orthogonal imaging tools was published in Biochemistry. Congrats Sierra!

January 2021

  • Pharm Sci rotation student Lila Halbers joins the lab for the winter quarter. Welcome!
  • Our latest collaborative work was published in Cell. Congrats!