The Prescher Lab
Expanding the imaging toolkit to spy on cellular communication
Our research team is crafting novel probes to "spy" on cells and decipher their communications in vivo. Cellular networks drive diverse aspects of human biology, ranging from immune function to memory formation. Breakdowns in these networks also underlie numerous pathologies. While cell-cell interactions play key roles in human health and disease, the mechanisms by which cells transact information in vivo are not completely understood. The number of cells types involved, the timing and location of their interactions, the molecular cues exchanged, and the long-term fates of the cells remain poorly characterized in most cases. We are designing and deploying custom tools to visualize cellular networks in real time—and with molecular precision—in physiologically relevant environments. Collectively, our work is decoding cellular communications relevant to infectious disease, cancer metastases, and immune function.
News and Events
- Colin and Jenn’s perspective on bioluminescent tools was published in ACS Biochemistry! Read it here!
- Our latest work on cyclopropenones was highlighted in ACS Chemical Biology. Read it here!
- Colin was awarded a graduate research fellowship from Allergan! Congratulations!
- Yusef and Zane were awarded undergraduate research fellowships from UROP and summer research fellowships from Allergan! Awesome job guys!
- Anna Love and Anastasia Ionkina officially join the lab. Welcome!
- Christine was awarded the UCI Chancellor’s Award of Distinction. Awesome job!
- Will successfully defended his thesis! Congrats Dr. Porterfield! He will be pursuing his postdoctoral studies with Wenjun Zhang at Cal Berkeley.
- Zach was awarded the Medical Research Postdoctoral Fellowship from the George Hewitt Foundation. Congrats!
- Jenn’s Nature Chemical Biology commentary with Luke Lavis and Zev Gartner is online! Check it out!
- Our latest work on bioorthogonal cyclopropenones was published in JACS! Congrats Dave (Row), and Hui-Wen!
- Undergraduate researchers Zane Long and Yusef Ibreighith join the lab. Welcome!
- Zi was awarded an NSF GRFP fellowship! Congrats, Zi!
- Krysten was featured in a summary article on the 2016 ICBS meeting in ACS Chemical Biology. Read it here!
- Krysten successfully defended her thesis! She will be joining the Lewis group at the University of Chicago to complete her postdoctoral studies. Congratulations Dr. Jones! We wish you the best of luck!
- New year, new paper! Our work on orthogonal bioluminescent probes was published in JACS. Congrats Will, Krysten, Colin, Dave, and Miranda!