Jianfeng Cai
jianfengcai@usf.edu
Assistant Professor Department of Chemistry University of South Florida Tampa, FL 33620 (Office) 813-974-9506
Postdoctoral Associate, Bioorganic Chemistry, Yale University, 2007-2009 Advisor: Professor Andrew D. Hamilton
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PhD, Bioorganic Chemistry, Washington University in St. Louis, 2006
Advisor: Professor John Stephen Taylor
Thesis Title: Design and Synthesis of Nucleic Acid Templated and Targeted Drugs and Probes -
MS, Nanjing University, China, 2000
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BS, Nanjing University, China, 1997 POSITIONS AND EMPLOYMENT
Postdoctoral Associate, Yale University, New Haven, CT
Assistant Professor, University of South Florida, Tampa, FL
Member, Drug Discovery Program, Moffitt Cancer Center, Tampa, FL
2007-2009
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2009-present
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2009-present
HONORS
2014 ChemComm Emerging Investigator
2011 Ralph E. Powe Junior Faculty Enhancement Award, Ridge Associated Universities (ORAU)
PROFESSIONAL AFFILIATIONS
Member, American Chemical Society (Organic Chemistry and Medicinal Chemistry Division)
RESEARCH INTEREST
Area: Bioorganic, Chemical Biology and Biophysics
Research Focus: Design, synthesis and investigation of bioactive peptidomimetics; development of novel nanomaterials
PUBLICATIONS
Work from Graduate and Postdoc.
1. Jianfeng Cai, Yun Lu*, Gi Xue and Wei Zhang. The reinforcement of Al filled Polyurethane system. Mod. Plastics Proc. Appl., 1999, 11 (6), 10.
2. Yun Lu*, Jianfeng Cai and Gi Xue. Molecular design of a soft interphase and its role in the reinforcement and toughening of aluminum powder-filled polyurethane. J. Adhes. Sci. Technol., 2001, 15, 71-82.
3. Jianfeng Cai, Xiaoxu Li, Xuan Yue, and John Stephen Taylor*. Nucleic acid-triggered fluorescent probe activation by the Staudinger reaction. J. Am. Chem. Soc., 2004, 126(50), 16324-16325.
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Jianfeng Cai, Xiaoxu Li, and John Stephen Taylor*. Improved nucleic acid triggered probe activation through the use of a 5-thiomethyluracil peptide nucleic acid building block. Org. Lett ., 2005, 7(5), 751- 754.
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Jianfeng Cai, Erik M. Shapiro*, and Andew D. Hamilton*. Self-assembled DNA quadruplex conjugated to MRI contrast agent. Bioconjugate Chem., 2009, 20(2), 205-208.
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Jianfeng Cai, Brooke Rosenzweig, and Andrew D. Hamilton*. Inhibition of Chymotrypsin by a self- assembled DNA quadruplex functionalized with cyclic peptide binding fragments. Chem. Eur. J., 2009, 15(2), 328-332.
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Jianfeng Cai, Dariusz Niedzwiedzki, Harry A. Frank*,and Andrew D. Hamilton*. Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA Quadruplex. Chem. Commun. 2010, 46, 544 - 546.
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Yao Cheng, Lun K. Tsou, Jianfeng Cai, Toshihiro Aya, Ginger E. Dutschman, Elizabeth A. Gullen, Susan P. Grill, Annie Pei-Chun Chen, Brett D. Lindenbach, Andrew D. Hamilton, Yung-chi Cheng*. A novel class of meso-tetrakis-porphyrin derivatives exhibit potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrob. Agents Chemother. 2010, 54(1), 197-206.
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Sourav Saha, Jianfeng Cai, Daniel Eiler and Andrew D. Hamilton*. Programing the formation of DNA and PNA quadruplexes by pi-pi stacking interactions. Chem. Commun., 2010, 46, 1685-1687.
10. Rongsheng E. Wang, Raj K. Pandita, Jianfeng Cai, Clayton R. Hunt, John-Stephen Taylor*. Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode. ChemBioChem, 2012, 13(1), 97-104.
Work from Independent Career at University of South Florida:
11. Yaogang Hu, Xiaolong Li, Said M. Sebti, Jiandong Chen, and Jianfeng Cai*. Design and Synthesis of AApeptides: A New Class of Peptide Mimics. Bioorg. Med. Chem. Lett., 2011, 21, 1469-1471.
12. Youhong Niu, Yaogang Hu, Xiaolong Li, Jiandong Chen, and Jianfeng Cai*. Gamma-AApeptides: Design, Synthesis and Evaluation. New J. Chem. 2011, 35, 542-545.
13. Youhong Niu, Alisha “Jonesy” Jones, Haifan Wu, Gabriele Varani,* and Jianfeng Cai*. γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem., 2011, 9 (19), 6604 - 6609.
14. Shruti Padhee, Yaogang Hu, Youhong Niu, Ge Bai, Haifan Wu, Frankie Costanza, Leigh West, Lacey Harrington, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Non-Hemolytic α-AApeptides as Antimicrobial Peptidomimetics. Chem. Commun. 2011, 47 (34), 9729 - 9731
15. Rongsheng E. Wang, Youhong Niu, Haifan Wu, Mohamad Nassir Amin, and Jianfeng Cai*. Development of NGR peptide-based agents for tumor imaging. Am. J. Nucl. Med. Mol. Imaging 2011, 1(1), 36-46.
16. Rongsheng E. Wang,* Haifan Wu, Youhong Niu, and Jianfeng Cai*. Improving the Stability of Aptamers by Chemical Modification. Curr. Med. Chem. 2011, 18, 4126-4138.
17. Rongsheng E. Wang, Yin Zhang, Jianfeng Cai, Weibo Cai, Ting Gao*. Aptamer-Based Fluorescent Biosensors. Curr. Med. Chem. 2011, 18, 4175-4184.
18. Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Lacey Harrington, Whitney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Identification of γ-AApeptides with potent and broad- spectrum antimicrobial activity. Chem. Commun. 2011, 47 (44), 12197 - 12199.
19. Rongsheng E. Wang, Youhong Niu, Haifan Wu, Yaogang Hu, Jianfeng Cai*. Development of NGR- Based Anti-Cancer Agents for Targeted Therapeutics and Imaging. Anticancer Agents Med. Chem. 2012, 12 (1), 76-86.
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Rongsheng E. Wang,* Frankie Costanza, Youhong Niu, Haifan Wu, Yaogang Hu, Whitney Hang, Yiqun Sun, Jianfeng Cai*. Development of self-immolative dendrimers for drug delivery and sensing. J. Control. Release. 2012, 159, 154-163.
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Ge Bai, Shruti Padhee, Youhong Niu, Rongsheng E. Wang, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular uptake of an α-AApeptide. Org. Biomol. Chem. 2012, 10 (6), 1149 - 1153.
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22. Youhong Niu, Ge Bai, Haifan Wu, Rongsheng E. Wang, Qiao Qiao, Shruti Padhee, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular translocation of a γ-AApeptide mimetic of Tat peptide. Mol. Pharmaceutics. 2012, 9(5), 1529–1534
23. Chuanhai Cao*, David A. Loewenstein, Xiaoyang Lin, Chi Zhang, Li Wang, Ranjan Duara, Yougui Wu, Alessandra Giannini, Ge Bai, Jianfeng Cai, Maria Greig, Elizabeth Schofield, Raj Ashok, Brent Small, Huntington Potter and Gary W. Arendash*. High Blood Caffeine Levels in MCI Linked to Lack of Progression to Dementia. J. Alz. Dis. 2012, 30, 559-572.
24. Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Qiao Qiao, Yaogang Hu, Lacey Harrington, Whittney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem. 2012, 55(8), 4003–4009.
25. Wen-Yang Gao , Youhong Niu , Yao Chen , Lukasz Wojtas , Jianfeng Cai , Yu-Sheng Chen and Shengqian Ma*. Porous Metal-Organic Framework Based on a Macrocyclic Tetracarboxylate Ligand Exhibiting Selective CO2 Uptake. CrystEngComm, 2012, 14, 6115-6117.
26. Zhongqiu Luo, Jialin Li, Neel R. Nabar, Xiaoyang Lin, Ge Bai, Jianfeng Cai, Shu-Feng Zhou, Chuanhai Cao*, Jinhuan Wang*. Efficacy of a Therapeutic Vaccine Using Mutated β-amyloid Sensitized Dendritic Cells in Alzheimer’s Mice. J. Neuroimmune Pharmacol., 2012, 7, 640-645.
27. Haifan Wu, Youhong Niu, Shruti Padhee, Rongsheng E Wang, Yaqiong Li, Qiao Qiao, Ge Bai, Chuanhai Cao, and Jianfeng Cai*. Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development. Chem. Sci., 2012, 3, 2570-2575.
28. Yunan Yang, Youhong Niu, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W. Engle, Todd E. Barnhart, Jianfeng Cai*, and Weibo Cai*. Radiolabeled γ-AApeptides: A New Class of Tracers for Positron Emission Tomography. Chem. Commun. 2012, 48, 7850-7852.
29. Haifan Wu, Mohamad Nassir Amin, Youhong Niu, Qiao Qiao, Nassier Harfouch, Abdelfattah Nimer, Jianfeng Cai*. Solid Phase Synthesis of γ-AApeptides Using a Novel Submonomeric Approach. Org. Lett. 2012, 14, 3446-3449.
30. Youhong Niu, Rongsheng E. Wang*, Haifan Wu, Jianfeng Cai*. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2012, accepted.
31. Yaogang Hu, Mohamad Nassir Amin, Shruti Padhee, Rongsheng E. Wang, Qiao Qiao, Ge Bai, Yaqong Li, Archana Mathew, Chuanhai Cao, and Jianfeng Cai*. Lipidated Peptidomimetics with Improved Antimicrobial Activity. ACS Med. Chem. Lett. 2012, 55, 4003-4009.
32. Youhong Niu, Haifan Wu, Rongfu Huang, Qiao Qiao, Frankie Costanza, Xi-Sen Wang, Yaogang Hu, Mohamad Nassir Amin, Anh-My Nguyen, James Zhang, Edward Haller, Shengqian Ma, Xiao Li, and Jianfeng Cai*. Nanorods formed from a new class of peptidomimetics. Macromolecules, 2012, 45, 7350–7355.
33. Neel R. Nabar, Fang Yuan, Xiaoyang Lin, Li Wang, Ge Bai, Jonathan Mayl, Yaqiong Li, Shu-Feng Zhou, Jinhuan Wang, Jianfeng Cai, Chuanhai Cao*. Cell Therapy: A Safe and Efficacious Therapeutic Treatment for Alzheimer’s Disease in APP+PS1 Mice. PLoS One, 2012, 7, 12, e49468.
34. Long Zhang, Qing Ji, Xuan Liu, Xingzhu Chen, Zhaohua Chen, Yanyan Qiu, Jian Sun, Jianfeng Cai, Huirong Zhu, and Qi Li. Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways. Cancer Sci., 2013, 104, 604-610.
35. Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai.* AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2013, 11, 4283-4290.
36. Haifan Wu, Peng Teng, Youhong Niu, Qi Li, Jianfeng Cai.* Polymyxin derivatives: a patent evaluation (WO2012168820). Expert Opin. Ther. Pat., 2013, 1075-81.
37. Yaqiong Li, Haifan Wu, Youhong Niu, Yaogang Hu, Qi Li, Chuanhai Cao, Jianfeng Cai.* Development of RNA Aptamer-Based Therapeutic Agents. Curr. Med. Chem., 2013, 20, 3655-3663.
38. Qing Ji, Xuan Liu, Xiaoling Fu, Long Zhang, Hua Sui, Lihong Zhou, Jian Sun, Jianfeng Cai, Jianmin Qin, Jianlin Ren*, Qi Li*. Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway. PLOS One, 2013, 8, 11, e78700.
39. Rongsheng E. Wang,* Yin Zhang, Ling Tian, Weibo Cai* and Jianfeng Cai. Antibody-Based Imaging of HER-2: Moving into the Clinic. Curr. Mol. Med., 2013, 13, 1523-1537.
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40. Frankie Costanza, Shruti Padhee, Haifan Wu, Yan Wang, Jesse Revenis, Chuanhai Cao, Qi Li* and Jianfeng Cai.* Investigation of antimicrobial PEG-poly(amino acid)s. RSC Advances, 2014, 4, 2089- 2095.
41. Haifan Wu, Yaqiong Li, Ge Bai, Youhong Niu, Qiao Qiao, Jeremiah Tipton, Chuanhai Cao,* Jianfeng Cai.* γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation. Chem. Commun., 2014, 2014 Emerging Investigators Issue.DOI: 10.1039/C3CC46685J
42. Yaqiong Li, Christina Smith, Haifan Wu, Shruti Padhee, Namitha Manoj, Joseph Cardiello, Qiao Qiao, Chuanhai Cao, Hang Yin,* and Jianfeng Cai.* Lipidated cyclic γ-AApeptides display both antimicrobial and anti-inflammatory activity. ACS Chem. Biol., 2014, 9, 211-217.
43. Haifan Wu, Peng Teng and Jianfeng Cai.* Quick access to multiple classes of peptidomimetics from common γ-AApeptide building blocks. Eur. J. Org., 2014, DOI: 201301841 / Eur. J. Org. Chem.
44. Shruti Padhee, Christina Smith, Haifan Wu, Yaqiong Li, Namitha Manoj, Qiao Qiao, Zoya Khan, Chuanhai Cao, Hang Yin,* and Jianfeng Cai.* The development of antimicrobial γ-AApeptides that suppress pro-inflammatory immune responses. ChemBioChem, 2014, DOI: cbic.201300709.
45. Wen-Yang Gao, Yao Chen, Youhong Niu, Kia Williams, Lindsay Cash, Pastor Perez, Lukasz Wojtas , Jianfeng Cai, Yu-Sheng Chen and Shengqian Ma*. Crystal engineering of an nbo topology MOF for chemical fixation of CO2 under ambient conditions. Angew Chem. Int. Ed., 2014, 53, ASAP.
46. Yan Wang, Daqian Song, Frankie Costanza, Huirong Zhu, Zhongze Fan,* Jianfeng Cai* and Qi Li.* Targeted Delivery of Tanshinone IIA-conjugated mPEG-PLGA-PLL-cRGD Nanoparticles to Hepatocellular Carcinoma. J. Biomed. Nanotechnol. 2014, accepted.
PATENTS (at USF)
1. Nathan J. Rice, Lennox Hoyte, and Jianfeng Cai. Materials and methods for reliable measurement of blood volume. 2011, PCT Int. Appl. WO 2011130304.
2. Jianfeng Cai, Youhong Niu, Haifan Wu, Shruti Padhee. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. 2012, Application No. 61589406.
3. Jianfeng Cai, Youhong Niu, Weibo Cai, and Hao Hong. RGD mimetic γ-AApeptides and methods of use. 2012, Application No. 61/667035.
4. Jianfeng Cai, Chuanhai Cao, Haifan Wu, Yaqiong Li, and Ge Bai. Methods of Synthesizing γ- AApeptides, γ-AApeptide Building Blocks, γ-AApeptide Libraries, and γ-AApeptide Inhibitors of Abeta40 Aggregates, 2013, Application No. 61/870874.
BOOK CHAPTERS
1. Youhong Niu, Yaogang Hu, Rongsheng E. Wang, Xiaolong Li, Haifan Wu, Jiandong Chen* and Jianfeng Cai*. AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions. Protein Interactions, 2012, ISBN: 978-953-51-0244-1.
2. Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai*. Synthesis of AApeptides. Peptide Modifications to Increase Metabolic Stability and Activity, 2013, ISBN: 978-1-62703-651-1.
3. Haifan Wu and Jianfeng Cai*. Engineering AApeptides for Translational Medicine. Engineering in Translational Medicine, 2013, ISBN: 978-1-62703-651-1.
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