Tuesday, June 21, 2022 - 10:30am


The formation of aggregates of the amyloidogenic peptide β-amyloid (Aβ), termed oligomers, is central to Alzheimer’s disease, where oligomers play a central role in neurodegeneration. The use of chemical model systems can help provide insights into the structures and interactions of oligomers, which are otherwise difficult to study because they are heterogeneous and metastable. In my dissertation, I describe the application of new tools to better understand the assembly and interactions of Aβ-derived oligomers and the molecular basis of Alzheimer’s disease. Collectively, these studies affirm the need for multiple techniques to accurately characterize oligomer behavior.


Gretchen Guaglianone


Nowick Group


NS2 2201