Abstract: Electrically conductive polymers are used in biosensing architectures of many kinds due to their biocompatibility, high electrical conductivity, and ease of polymerization. These factors permit creative techniques to fabricate innovative nanoscale biosensors for point-of-care diagnostic purposes. The focus of this thesis defense will be on the fabrication, sensing properties, and characterization of two different nanoscale, conductive polymer biosensors. The first device is the Virus BioResistor (VBR) which leverages a biocomposite thin film consisting of the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and M-13 virus particles which have been genetically engineered to bind a specific protein. This device offers rapid, point-of-care, label free biosensing for a variety of proteins and antibodies. The second concentration of the presentation is the miniaturization of the VBR from a 2D thin film to a quasi-0D single nanojunction. The resulting device is a nanojunction pH sensor consisting of a single 100 nm3 poly(aniline) junction between two ends of a gold nanowire. This device is the first conductive polymer sensor that has a single active sensing area that is nanoscopic in 3 dimensions, offering rapid and accurate transduction of local pH on the nanoscale. The study of this device provides insights into further development and design of nanoscopic conducting polymer sensors.