Abstract: 

Hydrofunctionalization is a powerful tool to add fragments across unsaturated building blocks to furnish more complex structures and introduce new stereocenters. My PhD studies have focused on Rh and Cu-catalyzed hydrofunctionalization to build both carbon-carbon and carbon-heteroatom bonds in a stereoselective and regioselective manner. With careful pairing of transition-metals and ligands, we successfully accessed chiral α,α-disubstituted-α-amino acid precursors, chiral cyclopropyl phosphines and N-arylated pyrazole motifs.