Elucidating Chemical Reaction Pathways in Protein Biosensors with Femtosecond Raman Spectroscopy

Elucidating transient molecular structural transformation steps from the reactant to product state during chemical reactions has been a grand challenge for physical chemists, biophysicists, and materials scientists. The main hurdle lies in the spatial and/or time resolution to spectroscopically characterize reaction pathways because the intrinsic atomic motions occur on ultrafast (i.e., femtosecond to picosecond) timescales.

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