Journey Towards Discovery of Navitoclax (ABT-263) - Orally Bioavailable and Efficacious Inhibitor of Bcl-2 Family Proteins

Probing primary photoinduced processes in biomolecules with tunable few-optical-cycle light pulses

Many light-induced processes in organic molecules, such as energy relaxation, energy/charge transfer and conformational changes, occur on ultrafast timescales, ranging from 10-14 to 10-13 s. The speed of such elementary processes is intimately linked to their efficiency, making ultrafast optical spectroscopy an invaluable tool for their investigation. Pump-probe spectroscopy requires both short pulses, in order to observe fast dynamics, and broad frequency tunability, to excite a system on resonance and probe optical transitions occurring at different frequencies.

Disrupting bacterial networks with synthetic small molecules

Studies of the Chlorosulfolipids: Methodology and Total Synthesis

Attractive Non-Covalent Interactions in Asymmetric Catalysis

A beta-Oxyanionic Organolithium-Weinreb Amide Coupling Strategy Towards the Syntheses of Aculeatins A, B, D and Strevertene A"

Designing, Measuring, and Controlling Molecular and Supramolecular Devices

Designing, Measuring, and Controlling Molecular and Supramolecular Devices Paul S. Weiss, <http://www.cnsi.ucla.edu/>California NanoSystems Institute and Departments of Chemistry & Biochemistry and Materials Science & Engineering, UCLA, Los Angeles, CA 90095, USA We use molecular design, tailored syntheses, intermolecular interactions, and selective chemistry to direct molecules into desired positions to create nanostructures, to connect functional molecules to the outside world, and to serve as test structures for measuring single or bundled molecules.

Functionalizing Surfaces for Efficient Solar Energy Conversion

Protein aggregation and drug inhibition studied with 2D IR spectroscopy.

Lanthanide Hydride Reduction Chemistry Including New Routes to Lanthanide Metallocene Dinitrogen Complexes

Lanthanide Hydride Reduction Chemistry Including New Routes to Lanthanide Metallocene Dinitrogen Complexes Speaker: Benjamin M. Schmiege University of California, Irvine Abstract: Although the lanthanides have many applications in polymerization catalysts, strong magnets, petroleum refining catalysts, optical lenses and light-emitting diodes, their chemistry remains underdeveloped.

UCI Department of Chemistry