Carbohydrate Polymer Assembly: How Do Mycobacteria Do It?
Laura L. Kiessling, University of WisconsinMadison
Carbohydrate polymers are the most abundant organic compounds on Earth. In higher organisms, they mediate fundamental processes, but they also can be essential for pathogen survival. For example, a lipid-linked polysaccharide containing 20-40 galactofuranose (Galf) residues is a key component of the mycobacterial cell wall. Galf residues are not found in humans; therefore, the enzymes mediating their incorporation should serve as antimicrobial targets.