There continues to be a need for innovation in crop protection technologies to provide a sustainable food supply for the growing population.  Global food protection will require the efforts from many including industry, farmers and government agencies.  Crops, in particular, require continued protection from the pressures of disease, insects and weeds. This talk will highlight several case studies that demonstrate approaches taken within Crop Protection Discovery Chemistry at Corteva™ Agriscience to develop novel small molecules that address these challenges.