Abstract: Solid-to-liquid state dynamic nuclear polarization (DNP) affords a sensitivity gain sufficient to enable single scan acquisition of NMR spectra at low concentration, of insensitive nuclei or of nuclei with low natural abundance. Combined with a rapid injection and mixing system, it becomes possible to obtain time-resolved data characterizing dynamic processes far from equilibrium. Kinetics and intermediates can be observed in various types of reactions, including enzyme catalyzed reactions of small-molecule substrates, fast organic reactions and polymerization reactions.

Chemoselective Staudinger Reactions – Powerful Tools for Organic Synthesis and Chemical Biology Prof. Dr. Christian P. R. Hackenberger, Freie Universität Berlin, Institut für Chemie und Biochemie, Takustr. 3, 14195 Berlin, Germany hackenbe@chemie.fu-berlin.de Chemoselective reactions have become important tools organic synthesis[1] as well as in modern life science, since they allow the study of biological and functional aspects of protein modifications.[2] Recently, we have identified the Staudinger-