In a recent publication in Nature Nanotechnology, Prof. Craig Martens of the UCI Chemistry Department, Prof. Zuzanna Siwy of the UCI Physics Department, and coworkers show how to induce current oscillations in a single nanopore [Nature Nanotechnology 3, 51 - 57 (2008)]. In strongly soluble salt solutions these systems act as molecular current rectifiers. When traces of sparingly soluble species, such as CaHPO₄ are present, the systems undergo an intriguing transformation from DC current flow (a) to quasiperiodic current oscillations (b) when a critical membrane voltage is reached. This transition corresponds to negative differential resistance on the current-voltage (I-V) curve. The authors show how voltage-induced precipitation and re-dissolution inside the nanopore underlie the ion current oscillations. The behavior of these nonlinear systems is very sensitive to experimental conditions. The frequency of oscillation is tunable from a fraction of Hz to tens of Hz. The authors also discuss possible application of these nonlinear oscillating systems to the building a single pore-based chemical sensor.