Tuesday, January 29, 2008

In a recent publication in the Journal of the American Chemical Society, Professor Blum and graduate students Yili Shi, Sonja Peterson, and Walter Haberaecker show that a gold/palladium bimetallic system catalyzes the synthesis of tri- and tetra-substituted olefins with high stereo- and regiocontrol. The unique reactivity produced by the bimetallic system is consistent with a gold Lewis acid that promotes back bonding of palladium into the alkyne substrate to initiate reactivity.