Professor Rob Corn and his group have been working to develop the method of surface plasmon resonance imaging (SPRI) for a variety of biosensing applications, with recent efforts focusing on achieving greater specificity and sensitivity from the SPRI measurements by coupling the surface bioaffinity process to an enzymatic transformation such as ligation or polymerase extension. For more information, please see the feature article "Creating Advanced Multifunctional Biosensors with Surface Enzymatic Transformations" by Hye Jin Lee, Alastair W. Wark, and Robert M. Corn in Langmuir, Vol. 22, pages 5241-5250 (2006).