Much like the pieces of a jig-saw puzzle, chirons originating from diverse natural sources or prepared by asymmetric synthesis must find their places as subunits in the intricate structures of target molecules. A right-brain eye-to-mind's eye visual relational thinking modality perceives such chirons as starting materials in the total synthesis of complex natural products such as avermectin B1a reserpine, the oidiolactone family, pactamycin, and ent-cyclizidine.  See Hanessian, p 6657. Professor Stephen Hanessian is the recipient of the 2012 Ernest Guenther Award in the Chemistry of Natural Products.