Abstract: Asymmetric catalysis has advanced rapidly as a discipline as a result of powerful modalities. Transition metal complexes, organocatalysts and enzymes have all played critical roles. Probably critical from the start, and in all three of these approaches to the field, noncovalent interactions are now appreciated to play a decisive role as determinants of selectivity. Peptide-based catalysts have proven to be a central platform for the systematic study of noncovalent interactions as determinants of selectivity in a wide variety of reactions. Design of new catalytic functionalities has been central to expanding the list of selective reactions and mechanistic paradigms that operate amidst the plethora of selectivity-defining noncovalent interactions that are now signatures of peptide-catalyzed processes. This lecture will focus on some of the newest developments in peptide-based catalysts with new catalytic functional groups.
Thursday, March 16, 2023 - 4:00pm