Events in physical chemistry.

Connecting the dots of immune machinery using a single-molecule lens

Abstract: The human immune system comprises a network of specialized cells and biomolecules that work together to defend the body against attacks by foreign invaders, known as antigens. This intricate network of cells and biomolecules also creates a complex puzzle. While the immune system has the capacity for an almost unlimited range of antigens, how does it achieve exquisite specificity? What enables immune cells to communicate over long distances and orchestrate a bodywide immune response?

Modeling of electrostatic and chemical properties of nanoscopic and microscopic aerosol droplets

Abstract: Atmospheric and man-made droplet aerosols show many commonalities in their physical and chemical properties.  Both systems are characterized by confinement and large surface to volume ratio, which alter the chemistry of many processes relative to their bulk solution counterparts.

Metal Homeostasis at the host – pathogen interface: from nutritional immunity to nutritional intoxication

Abstract: Antibiotic resistance is a global health concern that causes over one million deaths worldwide. Understanding molecular mechanisms of bacterial pathogenesis and the innate immune response is critical for identifying new antimicrobial therapeutic approaches. My lab is interested in characterizing the underlying determinants of metal homeostasis with an eye toward creating new antimicrobial agents. One-third of the proteome is predicted to comprise metalloproteins.


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