The application of nanotechnologies into medicine promises to offer solutions when applied to health challenges such as cancer. In particular the development of local therapies will reduce side effects associated with systemic administration of chemotherapy drugs, and will allow preservation or limited resection of organs with small size tumors. Local therapy is also indicated to overcome the intrinsic biological resistance of certain incurable malignancies, leading to failure of conventional treatment approaches.

We discuss new and ongoing work using Local Molecular Field (LMF) theory that provides a
general unified description of mixtures of charged and polar fluids as well as apolar Lennard-
Jones type (LJ) mixtures. Our initial focus is on the special case of a dilute aqueous solution of
AB solutes where the solutes may be charged or hydrophobic and the solvent W is described by
the classical SPC/E water model. There can be very interesting behavior of the AB pair
correlation function from solvent-induced effective interactions that presents difficult problems