Events in organic chemistry.

Synthetic Methodologies by which to Transform Carbohydrates or Nucleic Acids into Sustainable, Next-generation, Degradable/Digestible Functional Polymer Materials

A primary interest in the Wooley laboratory is the production of functional polymers from renewable sources that are capable of reverting to those natural products once their purpose has been served. A long-standing focus has been the development of synthetic methodologies that transform sugars, nucleic acids, amino acids and other natural products into polymer materials. This approach allows for the production of functional polymers from renewable sources that are capable of reverting to those natural products once their purpose has been served.

New Strategies for Stereoselective Radical Biocatalysis

Abstract: Radical reactions have enjoyed widespread applications in both small molecule and macromolecule synthesis. However, it remains challenging to control the stereochemistry of radical transformations and to discover novel modes of radical catalysis which are not known in either organic chemistry or biochemistry. Combining synthetic chemistry, enzymology and protein engineering, our group advanced two new biocatalytic strategies for stereoselective free radical processes.

Bristol Myers Squibb Symposium in Synthetic Organic Chemistry

BMS Symposium: 2:00 - 3:40 PM

Reception: 3:40 - 4:00 PM

BMS Lecture: 4:00 - 5:00 PM

Speakers:

Griffin Barnes, Vanderwal group: "A Synthesis of Alstonlarsine A via Alstolucines B and F Demonstrates the Chemical Feasibility of a Proposed Biogenesis"

Xintong Hou, Dong group: "Creative routes to unnatural amino acids, chiral phosphines, and nitrogen-heterocycles"

Dr. Thomas La Cruz, Bristol Myers Squibb: "A Small Molecule Process Development Story"

New Synthetic Tools for Peptide Medicinal Chemistry

Abstract: While the use of small organic molecules as therapeutic agents (drugs) goes back to antiquity, the therapeutic use of peptide drugs is a very recent phenomenon. Approximately 60 peptides have been introduced for clinical use in the past 25 years. 85% of these peptides contain at least one non-proteinogenic amino acid—those outside of the naturally encoded and translated amino acids—to confer metabolic stability, receptor potency and/or receptor selectivity to the peptide.

Reaching New Chemical Space with Excited States

In this talk I will provide several examples of photochemical reactions we used, or developed, to access a variety of structurally novel saturated heterocycles. Specifically, I will discuss our studies in the area of pyrrolinium photochemistry, the development of a Norrish-Yang reaction variant for accessing azetidines, and the photochemical decarbonylation of small heterocycles which give ylides (which react with pi systems).

A Radical Approach to Organic Chemistry

Synthetic chemists need ever better tools to synthesize the molecules of modern life, from life-changing pharmaceuticals to next generation materials. Further, there is increasing need for these transformations to be both step and atom efficient and sustainable, proceeding under mild conditions using earth abundant elements. Here we show how employing open shell intermediates strategically allows for challenging transformations to be achieved directly, from alkene difunctionalization to carboxylic acid deletion.

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