Events in organic chemistry.

Selective synthesis using light and electricity

Abstract: This seminar will describe our investigations into how organic radical ions–typically thought of as fleeting intermediates–can be tamed and exploited as a new family of organocatalysts and small molecule reagents. We identified selective generation of such species as a key hurdle stymying development of these systems. To address this problem, we have leveraged electrochemistry to develop new synthetic transformations driven by organic radical ions.

Searching for Selective Catalytic Reactions in Complex Molecular Environments

Abstract: This lecture will describe recent developments in our efforts to develop catalysts for asymmetric reactions, in particular for the preparation of densely functionalized, stereochemically complex structures.  Over time, our foci have been on enantioselectivity, site-selectivity and chemoselectivity.  In much of our current work, we are studying issues of enantioselectivity as a prelude to the extrapolation of catalysis concepts to more complex molecular settings where multiple issues are presented in a singular substrate.  Complex natural product, for example, will

Improving the Synthetic Organometallic Toolbox for Nitrogen- and Oxygen-Containing Compounds

Abstract: Transition metal catalysis has proven to be a powerful approach for rapidly constructing complex molecules through C–C bond forming reactions. However, unprotected amine and alcohol groups often make for poor substrates for these types of reactions. Our group has worked on developing new strategies to allow unprotected oxidatively-sensitive functional groups to be used directly in C–H activation and alkene functionalization reactions without the need for complex protecting/deprotecting strategies.

Transforming patients’ lives through science: Inventive vignettes from the pharmaceutical industry


This presentation will highlight at least two examples of drug discovery programs leveraging synthetic organic chemistry combined with innovative and thoughtful molecular design to create and evaluate new potential medicines for the benefit of patients and their communities. 

Orphaned Cyclopropanes

Abstract: The goal of the Hill group is to develop new reactions to obtain pyrethroids, small molecules used to combat vectors for malaria (e.g., Anopheles gambiae). We are particularly interested in identifying new small molecule pyrethroids with enhanced photostability, reduced off target toxicological properties to beneficial pollinators (honey bees), and reduced insect resistance profiles.

Making C–C Bonds at a Liberal Arts College

Abstract: The Cannon Lab at Occidental College is broadly interested in discovering new reactions that generate C–C bonds, with a special emphasis on catalytic and stereoselective processes. This seminar will describe our discoveries in photoredox-catalyzed anion oxidation for mild and atom-economical alkene functionalization, as well as our development of new auxiliaries for stereoselective enolate functionalization. The idiosyncrasies and challenges of conducting synthetic organic chemistry research with a group of undergraduates will also be discussed.

Dark Matter of the Human Genome

Abstract: Advanced methods in next-generation sequencing and proteogenomics have revealed thousands of previously invisible human protein-coding genes, increasing the known size of the human proteome by at least 10%. This previously unannotated proteomic “dark matter” includes small open reading frames (smORFs) encoding polypeptides of fewer than 100 amino acids, and alternative open reading frames (alt-ORFs) encoding proteins 100 amino acids or larger.


Subscribe to RSS - Organic Seminar