Abstract: Transition metal catalysis has proven to be a powerful approach for rapidly constructing complex molecules through C–C bond forming reactions. However, unprotected amine and alcohol groups often make for poor substrates for these types of reactions. Our group has worked on developing new strategies to allow unprotected oxidatively-sensitive functional groups to be used directly in C–H activation and alkene functionalization reactions without the need for complex protecting/deprotecting strategies.
This presentation will highlight at least two examples of drug discovery programs leveraging synthetic organic chemistry combined with innovative and thoughtful molecular design to create and evaluate new potential medicines for the benefit of patients and their communities.
Abstract: The goal of the Hill group is to develop new reactions to obtain pyrethroids, small molecules used to combat vectors for malaria (e.g., Anopheles gambiae). We are particularly interested in identifying new small molecule pyrethroids with enhanced photostability, reduced off target toxicological properties to beneficial pollinators (honey bees), and reduced insect resistance profiles.
Abstract: The Cannon Lab at Occidental College is broadly interested in discovering new reactions that generate C–C bonds, with a special emphasis on catalytic and stereoselective processes. This seminar will describe our discoveries in photoredox-catalyzed anion oxidation for mild and atom-economical alkene functionalization, as well as our development of new auxiliaries for stereoselective enolate functionalization. The idiosyncrasies and challenges of conducting synthetic organic chemistry research with a group of undergraduates will also be discussed.
Abstract: Advanced methods in next-generation sequencing and proteogenomics have revealed thousands of previously invisible human protein-coding genes, increasing the known size of the human proteome by at least 10%. This previously unannotated proteomic “dark matter” includes small open reading frames (smORFs) encoding polypeptides of fewer than 100 amino acids, and alternative open reading frames (alt-ORFs) encoding proteins 100 amino acids or larger.
Abstract: Automated synthesis is crucial to the development of a FAIR (Findable, Accessible, Interoperable, and Reusable) chemistry culture accessible to diverse scientists. This talk will discuss strategies for automated synthesis—solid-phase and solution-phase as well as batch and continuous flow techniques— in the context of carbohydrate and glycopeptide synthesis with a focus on how constraints can drive creativity in chemistry and in life.
Abstract: A brief introduction to metallacycle-mediated cross-coupling will be followed by a discussion focused on the use of alkenes and alkynes in these processes. Building on basic observations regarding reactivity and selectivity, a collection of complex convergent annulation reactions will be described.
Abstract: Polysaccharides are a major class of biomacromolecules that play important roles in both biology and material sciences. A long challenge for the characterization and utilization of polysaccharides is the heterogeneity of highly diverse natural polysaccharides. The efforts for chemically synthesizing complex polysaccharides have undergone rapid development in the past decade, but methods with scalability, sequence control, and high-throughput remain elusive.