Abstract: The selective generation and controlled reactivity of open-shell reactive species continues to serve as inspiration for new reaction development in chemical synthesis. This talk will describe recent advances using phosphorous-based reagents to generate carbon- and heteroatom-centered radicals via sequential atom-transfer radical additions as well as the use of copper compounds engaged in light-mediated metal-ligand co-operativity to harness and activate non-conjugated alkenes towards photocycloadditions.
Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An overview of how we approach process safety and a case study to demonstrate the application of our approach to a Barbier-type Grignard reaction in the synthesis of Kyprolis will be presented.
Abstract: RNA transcribed from the genome in the nucleus bears little resemblance to the RNA polymer it will ultimately become in the cytoplasm where it is translated into protein. Well-known processes such as capping, splicing and polyadenylation, as well as the recently discovered and ever-expanding list of diverse chemical modifications and editing, significantly alter the properties and fates of a given RNA during the course of its lifetime. These alterations regulate critical aspects of RNA function such as stability, transport, protein binding, and translation.
To Celebrate Black History Month, the Department of Chemistry is presenting special screening of “Percy Julian: Forgotten Genius” a biopic about a trailblazing Black scientist who earned a place in the parthenon of scientific greatness despite facing horrific racism throughout his life — including at prestigious academic institutions. Dr. Julian was the first Black chemist elected to the National Academy of Sciences (only the second African-American scientist to receive the honor), and was awarded >130 patents in chemistry. The first to synthesize the natural product physostigmine, Dr.
Our understanding of polar organic reactivity is based on relationships between rate and equilibrium constants. Thus, strong bases are generally considered to be good nucleophiles as well as poor nucleofuges. Though exceptions from this general rule have long been known, a systematic analysis has been problematic, because rate constants for the reactions of nucleophiles with C-centered electrophiles have often been correlated with Brønsted basicities (i. e., affinities towards the proton).
The Weiss laboratory invents new chemical tools to interrogate biology at the level of atoms and bonds. Many projects in the lab apply phage display to evolve peptides and proteins to bind cancer and diabetes-associated biomarkers. The resultant viruses with the disease-specific ligands have been directly wired into electrical circuits for measurement of disease marker levels in urine through collaboration with Prof. Reg Penner (UCI, Department of Chemistry).
Abstract: Complex molecule synthesis benefits from both methodological advances and strategic innovation. With the belief that a quality synthesis requires a solid strategy, our group focuses largely on synthesis design. Often, our targets are potentially valuable for their biological activities, in which case general applicability to a range of family members and/or unnatural analogues is incorporated into the design.
The gut microbiota contains millions of unique gene products that encode factors that directly and indirectly impact human physiology and disease. Here we focus on gut microbial glucuronidases that reverse the action of mammalian drug and endobiotic metabolizing glucuronidating factors. We show that these bacterial glucuronidase (GUS) enzymes can be potently, selectively and non-lethally inhibited to alleviate toxicities associated with cancer and pain medications. Surprisingly, the novel inhibitors designed employ a secondary amine that highjacks the catalytic cycle of the GUS glycoside