Events in organic chemistry.

Philicities, Fugalities, and Equilibrium Constants: A Quantitative Approach to Polar Organic Reactivity

Our understanding of polar organic reactivity is based on relationships between rate and equilibrium constants. Thus, strong bases are generally considered to be good nucleophiles as well as poor nucleofuges. Though exceptions from this general rule have long been known, a systematic analysis has been problematic, because rate constants for the reactions of nucleophiles with C-centered electrophiles have often been correlated with Brønsted basicities (i. e., affinities towards the proton).

Mechanisms of Taq DNA Polymerase and Severe COVID-19

The Weiss laboratory invents new chemical tools to interrogate biology at the level of atoms and bonds. Many projects in the lab apply phage display to evolve peptides and proteins to bind cancer and diabetes-associated biomarkers.  The resultant viruses with the disease-specific ligands have been directly wired into electrical circuits for measurement of disease marker levels in urine through collaboration with Prof. Reg Penner (UCI, Department of Chemistry).

Synthesis strategies toward complex bioactive diterpenoids

Abstract: Complex molecule synthesis benefits from both methodological advances and strategic innovation. With the belief that a quality synthesis requires a solid strategy, our group focuses largely on synthesis design. Often, our targets are potentially valuable for their biological activities, in which case general applicability to a range of family members and/or unnatural analogues is incorporated into the design.

Pharmaceutical Control of the Microbiome by Novel and Extant Therapeutics

The gut microbiota contains millions of unique gene products that encode factors that directly and indirectly impact human physiology and disease.  Here we focus on gut microbial glucuronidases that reverse the action of mammalian drug and endobiotic metabolizing glucuronidating factors.  We show that these bacterial glucuronidase (GUS) enzymes can be potently, selectively and non-lethally inhibited to alleviate toxicities associated with cancer and pain medications.  Surprisingly, the novel inhibitors designed employ a secondary amine that highjacks the catalytic cycle of the GUS glycoside

Deciphering the chemical crosstalk of host-gut microbiome interactions

Abstract: The gut microbiome comprises trillions of microorganisms that inhabit the mammalian intestines. These microbes regulate myriad aspects of host physiology, including factors that modulate many inflammatory diseases. Despite the abundance and prevalence of the gut microbiota, little is known regarding the pathways and mechanisms by which these microbes affect host health. Emerging evidence suggests that many small-molecule metabolites that are produced by the gut microbiota have the ability to modulate host defense mechanisms in various inflammatory diseases.

Universal Alkene Functionalization as an Aspirational Driver

Abstract: Vicinal (1,2-disubstituted) functional group motifs are ubiquitous in structurally complex small molecules that are of academic and industrial importance, including many widely used pharmaceutical agents. Many such functional group combinations, however, remain exceptionally challenging to synthesize. The goal of research in the Engle lab is to develop a general catalytic platform for alkene and alkyne difunctionalization to introduce a diverse array of functional groups at each of the two carbon atoms in a programmable fashion.

Hierarchical Strategies Towards Biointerfacing with Soft Optoelectronic Materials

The applications of functional nanomaterials towards biological interfacing continue to emerge in various fields, such as in drug delivery and tissue engineering. While the rational control of surface chemistry and mechanical properties have been achieved for several of these biocompatible systems, these biomaterials are rarely synthesized with optical and electronic functionalities that could be beneficial for controlling the behavior of excitable cells (e.g., neurons and cardiac cells) or for biosensing applications.

Digital Transformation in Manufacturing

Until recently, 3D printing was largely relegated to prototyping and small-scale projects

due to fundamental limitations—slowness and an inability to generate objects with adequate

mechanical strength and thermal properties that would entail widespread, durable utility. A

limited range of materials also hindered the ability to make parts comparable to injection molded


Rethinking the basic physics and chemistry, we invented Digital Light SynthesisTM (DLS)


Subscribe to RSS - Organic Seminar