Events in organic chemistry.

Reaching New Chemical Space with Excited States

In this talk I will provide several examples of photochemical reactions we used, or developed, to access a variety of structurally novel saturated heterocycles. Specifically, I will discuss our studies in the area of pyrrolinium photochemistry, the development of a Norrish-Yang reaction variant for accessing azetidines, and the photochemical decarbonylation of small heterocycles which give ylides (which react with pi systems).

Methods to Evaluate and Perturb the Activity of the Human Proteasome with Small Molecules

Abstract: The degradation of proteins is an essential cellular process. The proteasome, a multi-catalytic enzyme, is mainly responsible for degrading proteins that are no longer required by the cell. My lab has focused on the development of activity probes that can monitor real-time proteasome activity biochemically and in live cells. These probes can be applied in variety of analytical methods including confocal microscopy, flow cytometry, and fluorescent plate readers.

Organic Synthesis Lecture: Catalyst-enabled molecular nanocarbon synthesis and nanocarbon biology

Abstract: Molecular nanocarbons including nanographenes and polycyclic aromatic hydrocarbons are among the most important classes of compounds, with potential applications in nearly all areas of science and technology. Typically, molecular nanocarbons are structurally simple assemblies of benzene-based hexagons and one can imaginarily build up a range of structures with ease and the theoretically possible number of molecular nanocarbon structures (planar and nonplanar) is extraordinary.

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