Abstract: Automated synthesis is crucial to the development of a FAIR (Findable, Accessible, Interoperable, and Reusable) chemistry culture accessible to diverse scientists. This talk will discuss strategies for automated synthesis—solid-phase and solution-phase as well as batch and continuous flow techniques— in the context of carbohydrate and glycopeptide synthesis with a focus on how constraints can drive creativity in chemistry and in life.

Twitter: @NPohl_Group

Abstract: Polysaccharides are a major class of biomacromolecules that play important roles in both biology and material sciences. A long challenge for the characterization and utilization of polysaccharides is the heterogeneity of highly diverse natural polysaccharides. The efforts for chemically synthesizing complex polysaccharides have undergone rapid development in the past decade, but methods with scalability, sequence control, and high-throughput remain elusive.

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Photons have multiple enabling advantages to control chemical reactions and stimuli-responsive materials.  In this seminar, I will discuss our groups effort to design and develop a new class of negative photochromic molecules termed DASA, their incorporation into materials and subsequent effort to unlock their potential to convert light directly into mechanical work. Additionally, a new Diels–Alder based photoclick platform to enable bio-orthogonal chemistry with spatial control for biomaterial applications will be discussed.