Events in organic chemistry.

New Synthetic Tools for Precision Polymers & Sustainable Materials

Research in the Romero Polymer Lab focuses on the development of novel methodologies for precision synthesis and functionalization of polymeric materials, seeking to address longstanding challenges in stimuli-responsive materials, optoelectronically active polymers, and polymer sustainability. Our efforts utilize a variety of synthetic tools to achieve molecular-level control over polymer structure and properties, with a particular emphasis on photochemistry, electrochemistry, and main group chemistry.

Alkene and Arene Functionalizations: Synthesis of Heterocyclic Natural Products

My laboratory explores new strategies to directly transform alkenes and arenes for streamlining bioactive small molecule synthesis. This seminar will cover three themes representative of our research program: 1) oxidative Rh(III)/(IV)/(II)-catalyzed C–H functionalization en-route to benzylisoquinoline alkaloids, an approach distinct from conventional Rh(III) catalysis; 2) synergistic Brønsted acid/Lewis acid catalyzed Friedel–Crafts alkylations enabling direct reactions with unactivated, non-benzylic/allylic/propargylic alcohols; 3) total synthesis of eudemanolide natural products.

Precision glycocalyx editing to define novel therapeutic targets and modalities

The cellular glycocalyx is a complex and dynamic biological interface relaying information between cells and their surroundings. Comprised of membrane-associated glycolipids and glycoproteins, the glycocalyx controls fundamental biological processes, including fertilization, embryogenesis, tissue and organ development, or immunity. Despite being implicated in various diseases, glycans are rarely considered suitable targets for therapies or drug development. One reason for this anomaly is the characteristically weak affinity of individual glycans toward their protein partners.

Deciphering the Rules of Peptidoglycan Metabolism in Immune-Active Microbiota

All bacteria utilize the glycopeptide polymer peptidoglycan to shield themselves from environmental stress. Although often thought of as a "conserved" feature of the cell wall, peptidoglycan exhibits multiple levels of structural heterogeneity across our microbiota. Different bacteria use unique combinations of building blocks to assemble the biopolymer as well as collections of enzymes to remodel the scaffold during growth and division. This degradative process leads to a plethora of individual repeating units, which may escape the bacterium and activate host innate immune pathways.

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