Events in organic chemistry.

Chemical Biology and Medicinal Chemistry to Direct Neuroreceptors: Signaling and Proteomic Investigations

Dopamine and serotonin receptors are central to brain function, yet are extremely challenging to study, especially in precise regions and narrow timescales. Our goal is to create new chemical tools to study dopamine and serotonin GPCRs in living mammals, without the need for genetic manipulation.

Synthetic Methodologies by which to Transform Carbohydrates or Nucleic Acids into Sustainable, Next-generation, Degradable/Digestible Functional Polymer Materials

A primary interest in the Wooley laboratory is the production of functional polymers from renewable sources that are capable of reverting to those natural products once their purpose has been served. A long-standing focus has been the development of synthetic methodologies that transform sugars, nucleic acids, amino acids and other natural products into polymer materials. This approach allows for the production of functional polymers from renewable sources that are capable of reverting to those natural products once their purpose has been served.

New Strategies for Stereoselective Radical Biocatalysis

Abstract: Radical reactions have enjoyed widespread applications in both small molecule and macromolecule synthesis. However, it remains challenging to control the stereochemistry of radical transformations and to discover novel modes of radical catalysis which are not known in either organic chemistry or biochemistry. Combining synthetic chemistry, enzymology and protein engineering, our group advanced two new biocatalytic strategies for stereoselective free radical processes.

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