PhD defenses.

Understanding NO3 oxidation of monoterpenes at different scales: Insights from molecular modeling, chamber experiments, and field observations

Abstract: It has been shown though numerous field studies, laboratory measurements, and the occasional modeling study that NO3 radical oxidation of monoterpenes is a significant, though often overlooked, source of secondary organic aerosol (SOA). However, this generalization is complicated by the fact that while most abundantly emitted monoterpenes (e.g. β-pinene, ∆-carene, and limonene) have moderate-to-high SOA yields with NO3 radical, the most abundantly emitted monoterpene (α-pinene) has a negligible SOA yield with NO3.

Aqueous sequestration and solid-phase separation of actinyl ions with PAMAM dendrimers

Abstract: Nuclear energy is a sustainable baseload power source with low life cycle carbon emissions, and no emissions during power plant operations. Research into new separatory schemes and technology to reprocess used nuclear fuel (UNF) can further improve carbon emissions and the efficiency of the nuclear fuel cycle. Improved aqueous separatory and extraction agents have the additional benefit of making the use of radionuclides safer with their ability to carefully segregate selected materials from environments such as natural bodies of water or waste streams.

Bioorthogonal cyclopropenones for biomolecule ligation and reaction development

Abstract: Bioorthogonal chemistry enables researchers to study biomolecules in their native environments without perturbing endogenous cellular processes. Over the past two decades, significant strides have been made in developing new, and refining existing, bioorthogonal reactions. The continuously expanding toolbox has opened avenues for tackling increasingly complex biological questions. Despite these advances, limitations remain.

Fluorescent Teixobactin Probes

Abstract: Antibiotic resistance persists as serious threat against our ability to treat drug resistant infections. In 2016, teixobactin, a new antimicrobial peptide, was reported to kill Gram-positive pathogens without detectable resistance, a remarkable property that antibiotics lack. Mechanistic studies have shown that teixobactin binds to cell wall precursors, resulting in cellular lysis of bacteria. However, the cellular localization of teixobactin has not been characterized, and doing so would require a fluorescent teixobactin analogue.


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