PhD defenses.

Synthesis, Characterization, and Reactivity Studies on Transition Metal Amidophenolate Complexes

Abstract:

Catecholate-type ligands on transition metals have demonstrated the ability to act as proton and electron reservoirs, enabling diverse chemical transformations. This dissertation investigates how redox-active amidophenolate ligands control the electronic structure, reactivity and physical properties of transition metal complexes.

Chiral Lewis Acid Catalysis for P-Stereogenic Compounds: From Ligands to Therapeutics and Beyond

Abstract: 

Compounds containing stereogenic phosphorus atoms played a historically important role in the development of asymmetric catalysis, exemplified by early P-chiral phosphine ligands such as DIPAMP. More recently, P-stereogenic motifs have emerged in medicinal chemistry, as a growing number of drugs contain stereogenic P(V) centers bearing predominantly phosphorus–heteroatom bonds, which present distinct synthetic challenges.

Ruthenium and Molybdenum Complexes Bearing Redox-Active Ligands: C−H Activation, Oxidative Addition and Dyes

Abstract:

Redox-active ligands have demonstrated the ability to open up oxidative addition and reductive elimination reactions at formally redox-inactive metal centers. This talk will focus on systems that combine redox-active ligands and redox-active metal-centers that show rich oxidative addition chemistry and spectral properties. Unintended consequences of ligand design will be discussed, highlighted by evidence of a novel mode of reversible C−H activation.

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