PhD defenses.

Synthesis of CID-cleavable Protein Cross-linkers for the Elucidation of Protein Structure and Synthetic Progress Towards the Total Synthesis of Crokonoid A

Abstract: 

The characterization of protein-protein interactions and protein structure is integral to the understanding of biological processes and can facilitate identification of attractive targets for drug discovery. Protein cross-linking has emerged as a complementary method by which protein structure can be elucidated. Two CID-cleavable cross-linkers MSSO and DzYSO were synthesized and their syntheses will be discussed.

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