This dissertation focuses on understanding the propensity of group 6 and 10 transition metal complexes with multiple redox and proton non-innocent ligands to serve as proton and electron transfer agents.

Abstract:

The first study describes the conversion of sclareolide to C2-functionalized lissoclimide derivatives via key C–H functionalization and asymmetric Evans aldol addition steps. The selectivity of C–H functionalization at the C2 position of sclareolide using various approached is discussed. Additionally, halogen-π interactions within the 80S ribosomal pocket were investigated for all of the novel lissoclimide derivatives.

Abstract: 

The characterization of protein-protein interactions and protein structure is integral to the understanding of biological processes and can facilitate identification of attractive targets for drug discovery. Protein cross-linking has emerged as a complementary method by which protein structure can be elucidated. Two CID-cleavable cross-linkers MSSO and DzYSO were synthesized and their syntheses will be discussed.

Abstract:

Abstract