PhD defenses.

Catalysis with Ring Strain - Efforts towards Pyrazoles and Cyclic Tripeptides

Abstract:

Pyrazoles and cyclic tripeptides represent two classes of biologically relevant compounds with distinct synthetic challenges. For pyrazoles, the differentiation of two chemically similar nitrogen atoms can be complicated. Cyclic tripeptides, by contrast, are intrinsically strained, making them a largely underexplored yet promising synthetic target. In this defense, I will describe my efforts to address these challenges by leveraging transition-metal catalysis and ring strain.

Chemical Strategies Towards Hybrid One-Dimensional Wires That Approach the Sub-Nanometer Regime

Hybrid organic-inorganic materials offer a powerful platform for synergistically combining molecular tunability with collective, long-range ordered physical states. Yet achieving stable, surface addressable, and low-dimensional extended lattice hybrids—especially in true one-dimensional (1D) form—remains a key challenge.

Using Exploratory LC-MS Metabolomics to Identify Carnivory-Related Molecular Changes in Drosera Capensis

Abstract: 

Mass spectrometry (MS) is an ever-advancing technique, capable of detecting small molecules at incredibly low concentrations, while gathering the information necessary to identify unknown molecules. I have used LC-MS/MS to identify unknown small molecules in Drosera capensis, or the Cape Sundew. I will present basic LC-MS/MS data collection theory and guidance, and discuss how we used a combination of LC-MS/MS, genomics, and transcriptomics to monitor the response of D. capensis to a variety of treatments.

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