PhD defenses.

Thermodynamic Considerations for CO2 Activation and Further Reactivity of CO2 Reduction Products


Growing global energy demands and greenhouse gas emissions require the development of innovative technologies to both sustain the energy needs of the future and eliminate anthropogenic sources of climate change. By designing and deploying systems that capture, concentrate, and convert CO2 to useful feedstocks on large scale using renewable, carbonless energy sources, we may be able to achieve a net neutral carbon economy.

Preparation and Properties of Paramagnetic Mono- and Bimetallic Co Complexes

Abstract: Many important and synthetically challenging chemical reactions are carried out by metalloenzymes, including water oxidation, nitrogen fixation, O2 reduction, and oxidation of C–H bonds including as methane, fatty acids, and pharmaceuticals. Metalloenzymes are able to catalyze these reactions in part due to their ability to access reactive intermediates which is facilitated by the protein host.

Development of Polydisulfide Polymers for RNA Delivery

Abstract: The events of the COVID-19 pandemic have accelerated developments into mRNA therapies and research into novel mRNA delivery vehicles. While lipid-based nanoparticles have gained prominence, polymeric nanoparticle vehicles remain promising biodegradable vectors for new therapeutic RNAs. Within this dissertation two convergent approaches to polydisulfide polymer synthesis are explored.

From Proteins to Protons: Design of Nanoscopic Conductive Polymer Biosensors for Point-of-care Diagnostics

Abstract: Electrically conductive polymers are used in biosensing architectures of many kinds due to their biocompatibility, high electrical conductivity, and ease of polymerization. These factors permit creative techniques to fabricate innovative nanoscale biosensors for point-of-care diagnostic purposes. The focus of this thesis defense will be on the fabrication, sensing properties, and characterization of two different nanoscale, conductive polymer biosensors.

Borylated and Silylated Heterocyclic Scaffolds and Strategies for their Synthesis

Abstract: Heterocyclic scaffolds are present in greater than 85% of biologically active compounds. Metalated heterocycles, such as borylated and silylated heterocycles, are of interest because they enable the synthesis of diversely functionalized heterocycles, through the cross-coupling, conjugate addition, and oxidation reactivity of their metal–carbon bonds. Therefore, development of synthetic methods for the generation of metalated heterocycles has garnered significant attention.


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