PhD defenses.

Ruthenium and Molybdenum Complexes Bearing Redox-Active Ligands: C−H Activation, Oxidative Addition and Dyes

Abstract:

Redox-active ligands have demonstrated the ability to open up oxidative addition and reductive elimination reactions at formally redox-inactive metal centers. This talk will focus on systems that combine redox-active ligands and redox-active metal-centers that show rich oxidative addition chemistry and spectral properties. Unintended consequences of ligand design will be discussed, highlighted by evidence of a novel mode of reversible C−H activation.

Synthesis of Potent Anti-Parasitic Compounds and Biological Investigations Thereof

Abstract:

Human Babesiosis is a parasitic disease of the red blood cells caused primarily by the parasite Babesia duncani. Part one of this talk will discuss our work toward developing labeled analogs of the anti-hypertensive compound Fosinopril, which was found to possess potent anti-babesial activity. A range of C–H azidation techniques were attempted, but success was found in amidation of Fosinopril with a novel biotin derivative. Bromination of Fosinopril proved successful, though subsequent cross-couplings failed with functionalized biotin derivatives

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