PhD defenses.

From multifunctional linkers to catalysis: study of multiomics, hydroselenation, N–H insertion, and morpholine bioisosteres

Abstract: 

My Ph.D. research has encompassed areas in synthetic organic chemistry and chemical biology including the development of multifunctional linkers for an application in expansion microscopy, anti-Markovnikov hydroselenation of olefins, enantioselective pyrazole alkylation via N–H insertion, and intramolecular hydroamination to access scaffolds with bioisostere potential. Collectively, these studies have enabled the design of functional molecules and the development of novel transformations.

Chiral Lewis Acid Catalysis for P-Stereogenic Compounds: From Ligands to Therapeutics and Beyond

Abstract: 

Compounds containing stereogenic phosphorus atoms played a historically important role in the development of asymmetric catalysis, exemplified by early P-chiral phosphine ligands such as DIPAMP. More recently, P-stereogenic motifs have emerged in medicinal chemistry, as a growing number of drugs contain stereogenic P(V) centers bearing predominantly phosphorus–heteroatom bonds, which present distinct synthetic challenges.

Ruthenium and Molybdenum Complexes Bearing Redox-Active Ligands: C−H Activation, Oxidative Addition and Dyes

Abstract:

Redox-active ligands have demonstrated the ability to open up oxidative addition and reductive elimination reactions at formally redox-inactive metal centers. This talk will focus on systems that combine redox-active ligands and redox-active metal-centers that show rich oxidative addition chemistry and spectral properties. Unintended consequences of ligand design will be discussed, highlighted by evidence of a novel mode of reversible C−H activation.

Synthesis of Potent Anti-Parasitic Compounds and Biological Investigations Thereof

Abstract:

Human Babesiosis is a parasitic disease of the red blood cells caused primarily by the parasite Babesia duncani. Part one of this talk will discuss our work toward developing labeled analogs of the anti-hypertensive compound Fosinopril, which was found to possess potent anti-babesial activity. A range of C–H azidation techniques were attempted, but success was found in amidation of Fosinopril with a novel biotin derivative. Bromination of Fosinopril proved successful, though subsequent cross-couplings failed with functionalized biotin derivatives

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