The Kitaev material α-RuCl_3: Transient quantum magnetic state, unusual magnetic excitations, chiral phonons, and more

Prof. Paul van Loosdrecht's research interests include the fundamental properties of complex matter and the optical manipulation of molecular and complex systems using advanced linear and nonlinear spectroscopies. His current research is focused on non-equilibrium material physics and the influence of spin-orbit coupling, correlations, and topology on the physical properties of novel quantum materials. Prof. van Loosdrecht has held several academic leadership roles, including serving as Dean of the School of Mathematics and Natural Sciences at the University of Cologne.

From bioorthogonal to bioactive chemistry: Probing virus-host interactions for antiviral pathways

Abstract: Our lab uses different methods for the discovery of the molecular mechanisms by which different RNA viruses subvert human cells in order to discover strategies to block virus propagation. These include bioorthogonal chemistry, small molecule probes, activity-based protein profiling, and genetic code expansion techniques.

The active sites of copper oxygenases and their reactivity with H2O2


Lytic polysaccharide monooxygenases (LPMOs) are relatively recently discovered enzymes that catalyse the oxidation of polysaccharides, leading to chain cleavage.  LPMOs has transformed our understanding of biomass degradation, and—moreover—are now critical components in the enzymatic breakdown of biomass in the second generation bioethanol industry.1  We and others have also recently shown that LPMOs are key virulence factors in major plant diseases.2

Transition path times with applications to protein folding and tunneling times.

Abstract: Recent experimental measurements of the transition path time distributions of proteins moving from the folded to the unfolded state and vice versa, presented the theory with challenges. Analysis of the results suggested barrier heights that are much lower than the free energies of activation of the observed transitions, what are these barrier heights? Secondly, beyond the mere feat of following a protein as it folds or unfolds, is there anything really useful that we can actually learn from such experiments? These questions lead to a few insights.

Harnessing Chemoselective and Biocompatible Reactivity for Developing New Functional Materials and Biological Probes

The development of novel chemical reactions that achieve both high chemoselectivity and biocompatibility provide a foundation for the synthesis and application of new functional materials and biological probes. This presentation will provide two representative examples of this generalizable approach applied to systems spanning the biomolecule to cellular level.


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