BMS Symposium

The BMS Symposium is hosted by Professor Sergey Pronin and sponsored by Bristol Myers Squibb. It will feature lectures by Sarah Reisman of the California Institute of Technology and Natalie Holmberg Douglas of Bristol Myers Squibb.

2:00 PM: Introduction by Sergey Pronin

2:10 PM: Natalie Holmberg Douglas: “Discovery of BMS-986458, an Orally Bioavailable BCL6 Ligand-Directed Degrader”

3:10 PM: Reception Break

The "Rippled" Beta-Sheet: An Old Theory by Pauling and Corey Inspires New Biomaterials

In 2017 the Raskatov lab introduced the oligomer-to-fibril conversion paradigm, “Chiral Inactivation”, as a strategy to block neurotoxic actions of Aβ using mirror image peptides. The ensuing mechanistic research led the lab to the “rippled” beta sheet: a structural class predicted by Linus Pauling and Robert Corey of CalTech in 1953 and largely forgotten since. From 2022 onwards, (69 years later!), the Raskatov lab put the rippled sheet on a firm experimental foundation.

Current status of multi-site lambda dynamics, constant-pH molecular dynamics and the pyCHARMM/CHARMM simulation package”.

Professor Brooks is widely recognized as one of the pioneers of modern computational biophysics and biomolecular simulation. His work has profoundly shaped our understanding of protein and nucleic acid dynamics, folding, conformational transitions, free-energy landscapes, and drug-design, and has helped define the theoretical and computational foundations of biomolecular simulations. His group has also played a central role in the development and advancement of CHARMM, one of the most widely used biomolecular simulation programs. Professor Brooks received his Ph.D.

Simulating Energy Transfer and Storage in the Condensed Phase: From Photosynthesis to Batteries

I will discuss recent advances in modeling coupled electronic and vibrational dynamics that govern energy flow in condensed-phase systems. I will first present all-state quantum dynamics simulations of excitation energy transfer in the bacterial light-harvesting complex (LH2), showing how its ~90% efficiency and ~1 ps timescale arise from its concentric pigment architecture and nuclear quantum effects.

Nucleophilic Cobalt Photocatalysis and Organic Photoreductants: Two Enabling Approaches to Organic Synthesis

While carbon-centered radicals have become an increasingly important tool in organic synthesis, the breadth of radical precursors available to synthetic chemists remains underdeveloped. Many of the radical precursors employed in these methods require pre-functionalization of the initial feedstock chemical, adding undesired synthetic steps while generating additional byproducts after radical formation.

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