The active sites of copper oxygenases and their reactivity with H2O2

Abstract:

Lytic polysaccharide monooxygenases (LPMOs) are relatively recently discovered enzymes that catalyse the oxidation of polysaccharides, leading to chain cleavage.  LPMOs has transformed our understanding of biomass degradation, and—moreover—are now critical components in the enzymatic breakdown of biomass in the second generation bioethanol industry.1  We and others have also recently shown that LPMOs are key virulence factors in major plant diseases.2

Transition path times with applications to protein folding and tunneling times.

Abstract: Recent experimental measurements of the transition path time distributions of proteins moving from the folded to the unfolded state and vice versa, presented the theory with challenges. Analysis of the results suggested barrier heights that are much lower than the free energies of activation of the observed transitions, what are these barrier heights? Secondly, beyond the mere feat of following a protein as it folds or unfolds, is there anything really useful that we can actually learn from such experiments? These questions lead to a few insights.

Harnessing Chemoselective and Biocompatible Reactivity for Developing New Functional Materials and Biological Probes

The development of novel chemical reactions that achieve both high chemoselectivity and biocompatibility provide a foundation for the synthesis and application of new functional materials and biological probes. This presentation will provide two representative examples of this generalizable approach applied to systems spanning the biomolecule to cellular level.

Pages

Subscribe to RSS - Special Seminar